1. Aging Alters the Relative Contributions of the Sympathetic and Parasympathetic Nervous System to Blood Pressure Control in Women
- Author
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Gabrielle A. Dillon, Sarah E. Baker, Jacqueline K. Limberg, Michael J. Joyner, Timothy B. Curry, and Wayne T. Nicholson
- Subjects
Adult ,medicine.medical_specialty ,Mean arterial pressure ,Sympathetic Nervous System ,Adolescent ,Vasodilator Agents ,medicine.medical_treatment ,Blood Pressure ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Article ,Young Adult ,03 medical and health sciences ,Parasympathetic nervous system ,Basal (phylogenetics) ,0302 clinical medicine ,Heart Rate ,Parasympathetic Nervous System ,Internal medicine ,Heart rate ,Internal Medicine ,Valsalva maneuver ,Humans ,Medicine ,Aged ,business.industry ,Microneurography ,Middle Aged ,medicine.anatomical_structure ,Blood pressure ,Trimethaphan ,Cardiology ,Female ,sense organs ,business ,human activities ,030217 neurology & neurosurgery - Abstract
Autonomic support of blood pressure increases with age in humans. Large differences exist in the dose of trimethaphan (TMP) required for ganglionic blockade in young and older women. We asked whether differences in the dose of TMP required to achieve ganglionic blockade are because of differences in the relative contributions of the sympathetic and parasympathetic nervous system in control of blood pressure with age. Muscle sympathetic nerve activity (microneurography, peroneal nerve), heart rate (HR), and blood pressure were recorded before and during incremental doses of TMP camsylate until ganglionic blockade was achieved (absence of muscle sympathetic nerve activity and
- Published
- 2018