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Sex Differences in Sympathetic Neural-Hemodynamic Balance
- Source :
- Hypertension. 53:571-576
- Publication Year :
- 2009
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2009.
-
Abstract
- Among young normotensive men, a reciprocal balance between cardiac output and sympathetic nerve activity is important in the regulation of arterial pressure. In young women, the balance among cardiac output, peripheral resistance, and sympathetic nerve activity is unknown. Consequently, the aim of this study was to examine the relationship of cardiac output and total peripheral resistance to muscle sympathetic nerve activity in young women. Multiunit peroneal recordings of muscle sympathetic nerve activity were obtained in 17 women (mean±SEM: age 24±3 years) and 21 men (mean±SEM: age 25±5 years). Mean resting muscle sympathetic nerve activity was lower in women compared with men (19±3 versus 25±1 bursts minute −1 ; P P P =0.80) or women ( P =0.62). There was a positive relationship between total peripheral resistance and muscle sympathetic nerve activity ( r =0.62; P r =−0.69; P r =−0.27; P >0.05) or cardiac output ( r =0.23; P >0.05) in women. Our results demonstrate that men and women rely on different integrated physiological mechanisms to maintain a normal arterial pressure despite widely varying sympathetic nerve activity among individuals. These findings may have important implications for understanding how hypertension and other disorders of blood pressure regulation occur in men and women.
- Subjects :
- Adult
Male
medicine.medical_specialty
Cardiac output
Sympathetic nervous system
Sympathetic Nervous System
Hemodynamics
Blood Pressure
Article
Muscle, Smooth, Vascular
Norepinephrine
Heart Rate
Internal medicine
Heart rate
Internal Medicine
medicine
Humans
Cardiac Output
Sex Characteristics
business.industry
medicine.anatomical_structure
Blood pressure
Endocrinology
Vascular resistance
Female
Vascular Resistance
business
medicine.drug
Sex characteristics
Subjects
Details
- ISSN :
- 15244563 and 0194911X
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Hypertension
- Accession number :
- edsair.doi.dedup.....abae898b9377383b90acd685ba52bcfa