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5 results on '"Haruto Fujioka"'

3. A New Synthetic Route to the 1-Oxygenated Carbazole Alkaloids, Mukonine and Clausine E (Clauzoline I)

Author

Tominari Choshi, Haruto Fujioka, Shuhei Azuma, Shigeo Tohyama, and Satoshi Hibino

Subjects
Pharmacology, Indole test, chemistry.chemical_compound, Electrocyclic reaction, chemistry, Carbazole, Organic Chemistry, Total synthesis, Organic chemistry, Clausine E, Analytical Chemistry
Abstract

A new synthesis of the 1-oxygenated 1,3-disubstituted carbazole alkaloids, mukonine (la) and clausine (If) is described. The construction of the carbazole framework is based on an allene-mediated electrocyclic reaction involving the indole 2,3-bond. The 1,3-disubstituted 1-oxygenated carbazoles la and If are derived from the 1,2,3-trisubstituted carbazole.

Published
2009

4. Synthesis of 6-Methylindole-4,7-quinone and Anti-tumor Activities of Its Related Indolequinones

Author

Keiichi Kamoshita, Haruto Fujioka, Junko Nobuhiro, Takashi Ishizu, Tominari Choshi, Yoshikazu Sukenaga, Sakiko Maruyama, Miho Hirayama, and Satoshi Hibino

Subjects
Pharmacology, Antitumor activity, Indole test, Natural product, Electrocyclic reaction, Stereochemistry, Organic Chemistry, Ring (chemistry), Analytical Chemistry, Indolequinones, Quinone, chemistry.chemical_compound, chemistry, Cell culture
Abstract

We synthesized 6-methylindole-4,5-quinone (1b) in order to clarify the structure of natural product, 5-methylindole-4,5-quinone (la) isolated from Drupella fragum. The synthesis features the construction of the indole ring based on an electrocyclic reaction of a 3-alkenyl-2-propargylpyrrole intermediate. Two synthetic methylindolequinones and their related compounds were examined in human lung cancer cell line NCI-H460 and human breast cancer cell line MDA-MB-231.

Published
2006

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