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Synthesis of 6-Methylindole-4,7-quinone and Anti-tumor Activities of Its Related Indolequinones
- Source :
- HETEROCYCLES. 70:491
- Publication Year :
- 2006
- Publisher :
- The Japan Institute of Heterocyclic Chemistry, 2006.
-
Abstract
- We synthesized 6-methylindole-4,5-quinone (1b) in order to clarify the structure of natural product, 5-methylindole-4,5-quinone (la) isolated from Drupella fragum. The synthesis features the construction of the indole ring based on an electrocyclic reaction of a 3-alkenyl-2-propargylpyrrole intermediate. Two synthetic methylindolequinones and their related compounds were examined in human lung cancer cell line NCI-H460 and human breast cancer cell line MDA-MB-231.
Details
- ISSN :
- 03855414
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- HETEROCYCLES
- Accession number :
- edsair.doi...........56a14e4f75290d4ea4bf4668237a0490