Search

A report from the University of Debrecen in Hungary discusses the importance of proteomics in animal science and other biological sciences. Proteomics studies the presence and relative abundance of expressed proteins in cells, tissues, and biological fluids. The researchers used two-dimensional polyacrylamide gel electrophoresis (2D PAGE) to separate proteins based on their isoelectric point and mass. They tested different sample preparation and protein staining methods on meat, liver, and blood plasma. The study found that depleting major proteins in plasma is necessary for meat and liver samples. For more information, readers can refer to the article "Sample Preparation and Staining Methods for Two-Dimensional Polyacrylamide Gel Electrophoresis of Proteins from Animal Tissues" published in Scientific Papers Animal Science and Biotechnologies. [Extracted from the article]

Jamshoro, Pakistan, Asia, Amino Acids, Cholesterol, Emerging Technologies, Health and Medicine, Lipid Research, Lipids, Lipoproteins, Nanoparticles, Nanotechnology, Peptides, Peptides and Proteins, Proteins Keywords: Jamshoro; Pakistan; Asia; Amino Acids; Cholesterol; Emerging Technologies; Health and Medicine; Lipid Research; Lipids; Lipoproteins; Nanoparticles; Nanotechnology; Peptides; Peptides and Proteins; Proteins EN Jamshoro Pakistan Asia Amino Acids Cholesterol Emerging Technologies Health and Medicine Lipid Research Lipids Lipoproteins Nanoparticles Nanotechnology Peptides Peptides and Proteins Proteins 204 204 1 10/16/23 20231017 NES 231017 2023 OCT 19 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Current study results on Cholesterol have been published. [Extracted from the article]

Keywords: Blood Pressure; Health and Medicine; Peptides; Peptides and Proteins; Proteins EN Blood Pressure Health and Medicine Peptides Peptides and Proteins Proteins 285 285 1 10/24/23 20231026 NES 231026 2023 OCT 23 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in peptides. Our news correspondents obtained a quote from the research from Guilin University of Technology: "Milk-derived antihypertensive peptides with antihypertensive activity are prepared from milk protein by enzymatic hydrolysis or fermentation. Recent years, milk-derived antihypertensive peptides have been regarded as a natural and relatively safe bioactive peptide, which have attracted increasing attention due to their high biological activity, low toxicity, easy metabolism and good antihypertensive effect. [Extracted from the article]

Keywords: Antibodies; B-Lymphocytes; Blood; Blood Cells; Blood Proteins; California NanoSystems Institute; Emerging Technologies; Engineering; Genetics; Health and Medicine; Hematology; Hemic and Immune Systems; Immune System; Immunoglobulins; Immunology; Leukocytes; Nanosystems; Nanotechnology; Peptides; Peptides and Proteins; Plasma; Plasma Cells; Proteins EN Antibodies B-Lymphocytes Blood Blood Cells Blood Proteins California NanoSystems Institute Emerging Technologies Engineering Genetics Health and Medicine Hematology Hemic and Immune Systems Immune System Immunoglobulins Immunology Leukocytes Nanosystems Nanotechnology Peptides Peptides and Proteins Plasma Plasma Cells Proteins 501 501 1 08/28/23 20230831 NES 230831 2023 AUG 31 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- A collaboration led by UCLA and the Seattle Children's Research Institute has yielded new knowledge about the genes responsible for the production and release of immunoglobulin G, the most common type of antibody in the human body. Their analysis found that genes involved with producing energy and eliminating abnormal proteins were even more important for high IgG secretion than the genes containing instructions for making the antibody itself. [Extracted from the article]

Keywords: Bioinformatics; Biotechnology; Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign; Drugs and Therapies; Engineering; Genetics; Health and Medicine; Hematology; Hemolytic; Information Technology EN Bioinformatics Biotechnology Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign Drugs and Therapies Engineering Genetics Health and Medicine Hematology Hemolytic Information Technology 1827 1827 1 04/17/23 20230421 NES 230421 2023 APR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Living organisms produce a myriad of natural products which can be used in modern medicine and therapeutics. "So on a project like this, the Mitchell lab does the bioinformatics and identifies cool gene clusters, and the Zhao lab gets the synthetic biology system up and going to express these peptides and make them", Dommaraju explained. First the researchers use bioinformatics to compare and try to identify gene clusters that could produce potential RiPPs. [Extracted from the article]

Researchers Adler, Gawaz, and Munch have submitted a patent application for a pharmaceutical composition called Revacept(R), which is a dimeric fusion protein that inhibits platelet aggregation and prevents arterial thrombosis without increasing bleeding risk. The composition targets the collagen receptor GPVI and is designed for the treatment of thrombotic and vascular disorders. The patent application focuses on improving the stability, efficacy, and safety profiles of the fusion protein for parenteral application, offering a potential solution for personalized therapy in patients with cardiovascular conditions. [Extracted from the article]

Researchers at the Third Hospital of Shanxi Medical University in China conducted a study on the clinical significance of NLRP3 inflammasome and related cell molecules in early diabetic kidney disease in elderly patients. The study included 50 elderly patients with type 2 diabetes, 50 with early diabetic kidney disease, and 50 healthy individuals. Results showed that levels of NLRP3 inflammasome and related molecules were elevated in early elderly diabetic kidney disease and correlated with disease severity. The research was published in the Journal of Medical Biochemistry and can be accessed for free online. [Extracted from the article]

Researchers at Stanford Medicine have developed a new approach to cancer therapy by artificially bringing together two proteins to trigger cell death in cancer cells. This method aims to utilize the natural process of apoptosis, where cells self-destruct, to eliminate cancer cells specifically. The researchers have created a compound that targets BCL6, a protein involved in diffuse large cell B-cell lymphoma, and activates apoptosis genes, ultimately leading to the death of cancer cells. This innovative technique shows promise in killing cancer cells with high potency and minimal toxic side effects, offering a potential new avenue for cancer treatment. [Extracted from the article]

A multidisciplinary team of researchers from Michigan State University, in collaboration with experts from Karolinska Institute and the University of California, Berkeley, has developed a new method to detect diseases earlier by analyzing proteins in plasma for biomarkers. This innovative approach reduces interference from common proteins in blood, allowing for the detection of low-abundance proteins crucial for identifying diseases. The new testing method contributes to precision medicine, offering customized treatments based on genetics, environment, and lifestyle, ultimately leading to more effective healthcare solutions. [Extracted from the article]

A new report from Jagiellonian University Medical College in Krakow, Poland explores the connection between mast cell degranulation and bradykinin-induced angioedema. The researchers discuss the role of mast cells in activating the kallikrein-kinin system cascade, leading to the formation of bradykinin and the occurrence of angioedema. They also examine the potential involvement of the mast cell-related G protein-coupled receptor-X2 (MRGPRX2) in MC activation. The study raises questions about the relationship between mast cell degranulation and bradykinin production, as well as the influence of mast cell reactivity on the occurrence of angioedema attacks. Further research is needed to explore these connections. [Extracted from the article]

A recent study led by researchers from Mass General Brigham and Beth Israel Deaconess Medical Center has identified proteins in the blood that could help predict the risk of liver cancer years before diagnosis. Liver cancer is often diagnosed at a late stage, making treatment options limited. The study utilized proteomics to develop a prediction model for early detection of liver cancer, using a high-throughput proteomics platform to measure protein levels in blood samples. The researchers identified 56 plasma proteins that were significantly elevated in individuals with liver cancer compared to control individuals, and their predictive model showed greater accuracy than traditional risk factors. Further validation in larger and more diverse patient populations is needed. [Extracted from the article]

A patent application titled "Blood Preparation and Profiling" has been published online, detailing a new laboratory technique for producing a protein profile of red blood cell samples. The inventors have discovered that the levels of proteins in red blood cells can vary depending on how the blood is collected and processed. The new technique improves protein detection in blood and minimizes the impact of blood processing on protein profiles. The patent application offers methods, kits, and systems for generating protein profiles in red blood cell-enriched samples, including a method for comparing protein profiles in individuals with and without diseases or disorders. The application provides comprehensive information on the specific proteins and processing techniques involved. [Extracted from the article]

A study conducted by researchers at the University of New South Wales in Sydney, Australia, explores the effect of periodic insulin stimulation on Akt, a key component of the insulin signaling pathway. The study analyzes a mathematical model of Akt translocation to the plasma membrane and finds that the system quickly reaches a robust dynamic steady state in response to periodic insulin stimulation. However, further investigation is needed to determine if Akt's response is a crucial factor in the enhanced metabolic control observed under periodic insulin stimulation. The research was supported by the Australian Research Council and has been peer-reviewed. [Extracted from the article]

A report from Smolensk State Medical University discusses the use of thrombopoietin receptor agonists in the pharmacotherapy of pediatric immune thrombocytopenia (ITP). These drugs, such as Romiplostim and Eltrombopag, are commonly used as second-line treatments for chronic ITP in children who do not respond to first-line therapy. The report highlights the pharmacodynamic features of these drugs and suggests that their effect on immune tolerance in ITP should be further studied. The high cost of these drugs remains a limiting factor to their widespread use, but generic versions may help to address this issue. [Extracted from the article]

A study conducted by the Rawal Institute of Health Sciences in Islamabad, Pakistan, explores the use of nanotechnology in the treatment of chronic obstructive pulmonary disease (COPD). Nanotechnology is a commonly used technology in the field of medicine, known as nanomedicine, that aims to improve the effectiveness of medical procedures. The study focuses on the use of platinum-based drug delivery systems and their potential for treating various solid tumors, including head and neck, colorectal, and lung malignancies. The research provides an overview of the mechanisms of action and highlights the potential for further development in this area. [Extracted from the article]

A recent study conducted at the University of Minnesota explored the role of citrullinated peptides in rheumatoid arthritis. The researchers found that HLA-DR-bound citrullinated peptides do not act as neo-antigens and instead induce varying degrees of immune tolerance, which could potentially serve as a barrier to the development of rheumatoid arthritis. The study used fluorophore-conjugated HLA-DR tetramers containing citrullinated peptides from different proteins to track CD4+ T cells. The findings suggest that understanding immune tolerance mechanisms could be crucial in developing new treatments for arthritis. [Extracted from the article]

St. Louis, State:Missouri, United States, North and Central America, Hematology, Amino Acids, Biophysics, Enzymes and Coenzymes, Isomerases, Peptides, Proteins Keywords: St. Louis; State:Missouri; United States; North and Central America; Hematology; Amino Acids; Biophysics; Enzymes and Coenzymes; Isomerases; Peptides; Proteins EN St. Louis State:Missouri United States North and Central America Hematology Amino Acids Biophysics Enzymes and Coenzymes Isomerases Peptides Proteins 882 882 1 09/25/23 20230929 NES 230929 2023 SEP 25 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators discuss new findings in Hematology. [Extracted from the article]

Agammaglobulinemia, Antibodies, Biomarkers, Blood Protein Disorders, Blood Proteins, Diagnostics and Screening, Genetic Diseases and Conditions, Genetics, Health and Medicine, Hematologic Diseases and Conditions, Hemic and Lymphatic Diseases and Conditions, Hemorrhagic Disorders, Immune System Diseases and Conditions, Immunodeficiency, Immunoglobulins, Immunologic Deficiency Syndromes, Immunology, Inherited Blood Coagulation Disorders, Leukocyte Disorders, Leukopenia, Lymphatic Diseases and Conditions, Lymphopenia, Lymphoproliferative Disorders, Peptides, Proteins, Proteomics, Seattle Children's Hospital d/B/A Seattle Children's Research Institute, Syndromes, Wiskott-Aldrich Syndrome, X-Linked Genetic Diseases and Conditions. [Extracted from the article]