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Your search keyword '"Katayev A"' showing total 3 results
Start Over Author "Katayev A" Topic enantioselective synthesis Journal helvetica chimica acta
3 results on '"Katayev A"'

1. Asymmetric Synthesis of Perfluoroalkylated α‐Amino Acids through Generated Radicals Using a Chiral Ni(II) Complex

Author

Alexander F. Smol'yakov, Nadezhda V. Stoletova, Zalina T. Gugkaeva, Victor I. Maleev, Vladimir A. Larionov, Andrey D. Moshchenkov, and Dmitry Katayev

Subjects
Inorganic Chemistry, chemistry.chemical_classification, chemistry, Stereochemistry, Radical, Organic Chemistry, Drug Discovery, Enantioselective synthesis, Physical and Theoretical Chemistry, Biochemistry, Catalysis, Amino acid
Published
2020

2. Catalytic Enantioselective Synthesis of a 3-Aryl-3-benzyloxindole (=3-Aryl-3-benzyl-1,3-dihydro-2H-indol-2-one) Exhibiting Antitumor Activity

Author

Dmitry Katayev and E. Peter Kündig

Subjects
Stereochemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, Enantioselective synthesis, Inorganic Chemistry, chemistry.chemical_compound, Amide, Drug Discovery, Indolin-2-one derivative, Oxindole, Physical and Theoretical Chemistry, 010405 organic chemistry, Ligand, Aryl, Organic Chemistry, 0104 chemical sciences, 3. Good health, chemistry, Anticancer agents, Intramolecular force, ddc:540, Carbene
Abstract

A palladium-catalyzed intramolecular α-arylation of an amide in the presence of a bulky chiral N-heterocyclic carbene ligand is the key step in the first catalytic synthesis of (3R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-3-(3-methoxyphenyl)-2H-indol-2-one ((R)-5). This oxindole, in racemic form, had been shown previously to be an anticancer agent. (R)-5 was obtained with an overall yield of 45% and with 96% enantioselectivity.

Published
2012

3. Catalytic Enantioselective Synthesis of a 3-Aryl-3-benzyloxindole (=3-Aryl-3-benzyl-1,3-dihydro-2 H-indol-2-one) Exhibiting Antitumor Activity.

Author

Katayev, Dmitry and Kündig, E. Peter

Subjects
*ENANTIOSELECTIVE catalysis, *ANTINEOPLASTIC agents, *OXINDOLES, *HETEROGENEOUS catalysis, *TARTARIC acid
Abstract

A palladium-catalyzed intramolecular α-arylation of an amide in the presence of a bulky chiral N-heterocyclic carbene ligand is the key step in the first catalytic synthesis of (3 R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-3-(3-methoxyphenyl)-2 H-indol-2-one (( R)- 5). This oxindole, in racemic form, had been shown previously to be an anticancer agent. ( R)- 5 was obtained with an overall yield of 45% and with 96% enantioselectivity. [ABSTRACT FROM AUTHOR]

Published
2012
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