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Catalytic Enantioselective Synthesis of a 3-Aryl-3-benzyloxindole (=3-Aryl-3-benzyl-1,3-dihydro-2 H-indol-2-one) Exhibiting Antitumor Activity.
- Source :
-
Helvetica Chimica Acta . Nov2012, Vol. 95 Issue 11, p2287-2295. 9p. - Publication Year :
- 2012
-
Abstract
- A palladium-catalyzed intramolecular α-arylation of an amide in the presence of a bulky chiral N-heterocyclic carbene ligand is the key step in the first catalytic synthesis of (3 R)-6-chloro-3-(3-chlorobenzyl)-1,3-dihydro-3-(3-methoxyphenyl)-2 H-indol-2-one (( R)- 5). This oxindole, in racemic form, had been shown previously to be an anticancer agent. ( R)- 5 was obtained with an overall yield of 45% and with 96% enantioselectivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0018019X
- Volume :
- 95
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Helvetica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 83486956
- Full Text :
- https://doi.org/10.1002/hlca.201200477