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A study conducted at the University of Michigan has found that human gonads do not contribute to the circulating pool of 11-oxygenated androgens. The researchers used liquid chromatography-tandem mass spectrometry to measure 13 steroids in blood samples from patients and found that while hormones like androstenedione and testosterone were higher in gonadal veins compared to peripheral veins, 11-oxygenated androgens remained similar. The study concluded that despite producing significant amounts of androstenedione and testosterone, human gonads are not relevant sources of 11-oxygenated androgens. This research has been peer-reviewed and published in The Journal of Clinical Endocrinology & Metabolism. [Extracted from the article]

A study conducted at the University of North Carolina investigated the impact of intensive endurance exercise on androgenic steroid hormones in athletic women. Fifteen normally menstruating women participated in the study, completing treadmill running until volitional fatigue. Blood samples were collected at various time points during exercise and recovery. The study found that the levels of steroid hormones, except for free testosterone, significantly increased at volitional fatigue compared to pre-exercise levels. These hormone levels remained elevated during early recovery but were suppressed at 24 hours of recovery. The study suggests that a longer recovery period is needed to establish a resting endocrine equilibrium. [Extracted from the article]

A recent study conducted by the Chinese University of Hong Kong has found that androgen levels during pregnancy can impact cervical remodeling and may be associated with adverse pregnancy outcomes. The researchers developed gestational age-specific reference intervals for total testosterone (TT), androstenedione (A4), and 17-hydroxyprogesterone (17-OHP) to aid in the diagnosis of maternal hyperandrogenism. The study also found that women diagnosed with preeclampsia had significantly higher levels of A4, TT, and 17-OHP compared to non-preeclampsia cases. These findings provide valuable insights into the hormonal changes that occur during pregnancy and their potential implications for maternal and fetal health. [Extracted from the article]

A study conducted by researchers at the First Affiliated Hospital of Shenzhen University in China examined the association between Life's Essential 8 (LE8) behaviors and male biochemical androgen deficiency (MBAD) using data from the National Health and Nutrition Examination Survey (NHANES) database. The study included 3,094 male participants aged 20 years and above, with 805 of them diagnosed with MBAD. The researchers found that LE8 was independently associated with MBAD and total testosterone levels, even after adjusting for confounding factors. The study also revealed a non-linear relationship between LE8 behaviors and MBAD and total testosterone levels. The researchers concluded that LE8 could be a protective factor for MBAD and a potential approach to promote male endocrine sexual function. [Extracted from the article]

A research report from Tokyo, Japan discusses the connection between syndromic autism spectrum conditions (ASC) and hypogonadism, specifically in cases such as Klinefelter syndrome. The report proposes the Enhanced Perceptual Functioning model as an alternative to the Extreme Male Brain theory, explaining the co-emergence of ASC, savant traits, and giftedness with atypical sexual differentiation. The model suggests that overexcitability of primary sensory inputs leads to enhanced local to global processing of stimuli, hindering communication signal abstraction. Weaker inhibitory function and atypical synapse formation contribute to this difference, along with deficiency in monitoring inner sensory information. The report also explores the possibility that estrogen deficiency interrupts GABA shift, causing sensory processing atypicality, and provides clues for understanding the common underpinnings of neurodevelopmental disorders and gifted populations. [Extracted from the article]

A recent report from the University of Edinburgh discusses the relationship between androgens and immune cell function. The research suggests that androgens can affect immune responses and contribute to differences in the prevalence and severity of inflammatory conditions. Androgens have been found to alter immune cell composition, phenotype, and activation, as well as the expression and secretion of inflammatory mediators. However, the effects of androgens on the immune system are complex and can vary depending on the specific cell type and tissue context. Further research is needed to fully understand the molecular pathways involved in the interaction between endocrine and inflammatory signals. [Extracted from the article]

A recent study conducted by researchers at Marmara University in Istanbul, Turkey, focused on 3'-Phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2) deficiency, a rare disorder caused by genetic mutations in the PAPSS2 gene. The study found that patients with this deficiency commonly experience bone abnormalities and disproportionate short stature, while symptoms of androgen excess are less frequently observed. The researchers reviewed the clinical, molecular, and biochemical features of 79 reported patients with PAPSS2 deficiency. This information provides valuable insights into the understanding of this rare disorder. [Extracted from the article]

According to a preprint abstract, male medaka fish have two androgen signaling pathways that determine their behavior towards other males and females. Medaka lacking one subtype of androgen receptor are less aggressive towards males and instead court them, while those lacking the other subtype are less motivated to mate with females and attack them instead. The study suggests that male medaka make adaptive decisions to mate or fight based on the activation of one of these two complementary androgen signaling pathways, depending on the sex of the other fish they encounter. However, it is important to note that this research has not yet been peer-reviewed. [Extracted from the article]

A new report from the University of Sydney provides fresh data on endocrinology, specifically focusing on serum testosterone measurements in clinical practice. The study found that direct immunoassays used for testosterone measurements have method-specific bias, while liquid chromatography-mass spectrometry (LCMS) is more accurate and specific. The study also examined the within-person variability of serum testosterone in healthy men using LCMS measurement and identified the most sensitive androgen biomarkers to age and testosterone. The findings may be useful for future studies on androgen action in male aging. [Extracted from the article]

Outcome measures: The saliva samples were analyzed for five androgens (testosterone, androstenedione (A4), 17-hydroxyprogesterone (17-OHP), 11-ketotestosterone (11-KT) and 11b-hydroxyandrostenedione (11-OHA4)) using LC-MS/MS; in addition, salivary dehydroepiandrosterone (DHEA) and oestradiol (OE2) were analyzed by ELISA. Keywords: Adolescence; Health and Medicine EN Adolescence Health and Medicine 2631 2631 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on adolescence are presented in a new report. [Extracted from the article]

Brain, Central Nervous System, Diencephalon, Endocrinology, Health and Medicine, Hypothalamus Keywords: Brain; Central Nervous System; Diencephalon; Endocrinology; Health and Medicine; Hypothalamus EN Brain Central Nervous System Diencephalon Endocrinology Health and Medicine Hypothalamus 6478 6478 1 10/09/23 20231013 NES 231013 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in endocrinology. [Extracted from the article]

Therefore, the objective of this study was to assess QoL in previous illicit androgen users compared with current illicit androgen users and controls who had never used androgens." Keywords: Clinical Endocrinology and Metabolism; Health and Medicine; Quality of Life EN Clinical Endocrinology and Metabolism Health and Medicine Quality of Life 4563 4563 1 10/03/23 20231006 NES 231006 2023 OCT 6 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on clinical endocrinology and metabolism is the subject of a new report. [Extracted from the article]

The variables that were positively associated with the cumulative time of androgen abuse during the 2 years of follow-up were historical cumulative androgen exposure and the intention to take part in bodybuilding competitions. A Prospective Two Year Follow Up of 100 Male Androgen Abusers) The factors that predicted future androgen abuse may assist in harm reduction strategies that aim to minimize long-term health problems in androgen abusers.". [Extracted from the article]