1. The epidemiology, surgical management, and impact of margins in skull and mandibular osseous-site tumors
- Author
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Sina J. Torabi, Benjamin L. Judson, Saral Mehra, Alexandra T. Bourdillon, Samipya Kafle, Parsa P. Salehi, and Rahmatullah Rahmati
- Subjects
medicine.medical_specialty ,Treatment outcome ,Mandible ,Sarcoma, Ewing ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,Positive Margins ,Humans ,Retrospective Studies ,Osteosarcoma ,business.industry ,Skull ,Cancer ,Margins of Excision ,medicine.disease ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Cohort ,Chordoma ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
The aim of the study was to characterize the epidemiology and treatment outcomes of head and neck (HN) osseous-site tumors.Descriptive analyses and multivariate Cox regressions were performed to analyze the effect of surgery on overall survival (OS) utilizing the National Cancer Database (2004-2016).Of 2449 tumors, surgery was utilized in 84.5% of cases. OS was worse in osteosarcoma (5-year OS: 53.4% [SE: 2.5%]) compared with cartilage tumors (5-year OS: 84.6% [SE: 1.8%]) (log-rank P .001). Treatment regimens that included surgery were associated with improved OS on multivariate analysis (hazard ratio [HR] 0.495 [95% CI: 0.366-0.670]). Positive margins were found in 40.8% of cases, and associated with decreased OS in osteosarcomas (HR 1.304 [0.697-2.438]).Treatment that included surgery was associated with an increased OS within our cohort of HN osseous-site tumors, although the rates of positive margins were40%. These findings may be limited by inherent selection bias in the database.
- Published
- 2019