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The epidemiology, surgical management, and impact of margins in skull and mandibular osseous-site tumors
- Source :
- HeadneckREFERENCES. 42(11)
- Publication Year :
- 2019
-
Abstract
- The aim of the study was to characterize the epidemiology and treatment outcomes of head and neck (HN) osseous-site tumors.Descriptive analyses and multivariate Cox regressions were performed to analyze the effect of surgery on overall survival (OS) utilizing the National Cancer Database (2004-2016).Of 2449 tumors, surgery was utilized in 84.5% of cases. OS was worse in osteosarcoma (5-year OS: 53.4% [SE: 2.5%]) compared with cartilage tumors (5-year OS: 84.6% [SE: 1.8%]) (log-rank P .001). Treatment regimens that included surgery were associated with improved OS on multivariate analysis (hazard ratio [HR] 0.495 [95% CI: 0.366-0.670]). Positive margins were found in 40.8% of cases, and associated with decreased OS in osteosarcomas (HR 1.304 [0.697-2.438]).Treatment that included surgery was associated with an increased OS within our cohort of HN osseous-site tumors, although the rates of positive margins were40%. These findings may be limited by inherent selection bias in the database.
- Subjects :
- medicine.medical_specialty
Treatment outcome
Mandible
Sarcoma, Ewing
03 medical and health sciences
0302 clinical medicine
Epidemiology
medicine
Positive Margins
Humans
Retrospective Studies
Osteosarcoma
business.industry
Skull
Cancer
Margins of Excision
medicine.disease
medicine.anatomical_structure
Otorhinolaryngology
030220 oncology & carcinogenesis
Cohort
Chordoma
Radiology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10970347
- Volume :
- 42
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- HeadneckREFERENCES
- Accession number :
- edsair.doi.dedup.....df7390742f016ba2b3c96286e1e43126