57 results on '"De Bree, Remco"'
Search Results
2. Squamous cell carcinoma of the nasal vestibule in the Netherlands: A clinical and epidemiological review of 763 cases (2008-2021).
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van de Velde LJ, Scheurleer WFJ, Braunius WW, Devriese LA, de Ridder M, de Bree R, Breimer GE, van Dijk BA, and Rijken JA
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- Humans, Netherlands epidemiology, Male, Female, Aged, Middle Aged, Incidence, Adult, Aged, 80 and over, Neoplasm Staging, Disease-Free Survival, Survival Rate, Nose Neoplasms pathology, Nose Neoplasms epidemiology, Nose Neoplasms mortality, Nose Neoplasms therapy, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell mortality, Nasal Cavity pathology, Registries
- Abstract
Background: Squamous cell carcinoma of the nasal vestibule (SCCNV) is a rare disease, distinctly different in presentation, treatment, and outcome from squamous cell carcinoma (SCC) of the nasal cavity and paranasal sinuses. However, these are often not analyzed separately., Methods: The Netherlands Cancer Registry (NCR) and pathology reports from the Dutch Nationwide Pathology Databank (PALGA) were used to identify all newly diagnosed SCCNV cases in the Netherlands between 2008 and 2021., Results: A total of 763 patients were included. The yearly incidence rate displayed a significant downward trend with an annual percentage change (APC) of -3.9%. The 5-year overall survival (OS) and disease-free survival were 69.0% and 77.2%, respectively. The 5-year relative survival was 77.9% and improved slightly over the inclusion period. OS for patients who were staged cT3 appeared to be worse than those staged cT4a, calling the applicability of the TNM-classification into question., Conclusion: SCC of the nasal vestibule is rare, with declining incidence rates. Introducing a specific topography code for SCCNV is recommended to enhance registration accuracy. The TNM classification seems poorly applicable to SCCNV, suggesting the need to explore alternative staging methods., (© 2024 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2024
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3. Reply to Letter to the Editor: "Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study".
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Adriaansens CMEM, de Koning KJ, de Bree R, Breimer GE, van Es RJJ, and Noorlag R
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- Humans, Mouth Mucosa surgery, Mouth Mucosa pathology, Feasibility Studies, Ultrasonography, Interventional, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell surgery, Carcinoma, Squamous Cell pathology, Mouth Neoplasms diagnostic imaging, Mouth Neoplasms surgery, Mouth Neoplasms pathology
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- 2023
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4. A closer look at the resection margins of buccal mucosa cancer: Their influence on local recurrence free survival.
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Adriaansens CMEM, Noorlag R, Visscher WP, de Bree R, Breimer GE, and van Es RJJ
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- Humans, Margins of Excision, Retrospective Studies, Mouth Mucosa surgery, Mouth Mucosa pathology, Squamous Cell Carcinoma of Head and Neck surgery, Neoplasm Recurrence, Local pathology, Mouth Neoplasms pathology, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms
- Abstract
Background: The adequate surgical margin for local control of buccal mucosa squamous cell carcinoma (BMSCC) is under debate. This study investigates surgical margins and other factors associated with local recurrence free survival (LRFS) in a large cohort of BMSCC patients., Methods: Multiple factors were evaluated retrospectively in 97 patients with BMSCC. Cox-regression and Kaplan-Meier curves were used for analysis., Results: The local recurrence rate was 23%. The tumor-free margin was <5.0 mm in 89% of the patients and the deep margin was significantly more often inadequate. Multivariate analysis associated pT3-classification, former smokers, tumor-free margin status, and postoperative (chemo)radiation (PO(ch)RT) with local recurrence. Re-resections did not improve LRFS in patients with <5.0 mm tumor-free margins., Conclusions: Adequate tumor-free margins are pivotal for LRFS of BMSCC. PO(ch)RT, not re-resection, can improve LRFS in patients with <5.0 mm tumor-free margins., (© 2023 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2023
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5. Correction to "Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study".
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Adriaansens CMEM, de Koning KJ, de Bree R, Dankbaar JW, Breimer GE, van Es RJJ, and Noorlag R
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- 2023
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6. Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study.
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Adriaansens CMEM, de Koning KJ, de Bree R, Dankbaar JW, Breimer GE, van Es RJJ, and Noorlag R
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- Humans, Mouth Mucosa diagnostic imaging, Mouth Mucosa surgery, Mouth Mucosa pathology, Feasibility Studies, Margins of Excision, Squamous Cell Carcinoma of Head and Neck diagnostic imaging, Squamous Cell Carcinoma of Head and Neck surgery, Squamous Cell Carcinoma of Head and Neck pathology, Ultrasonography, Interventional, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell surgery, Carcinoma, Squamous Cell pathology, Mouth Neoplasms diagnostic imaging, Mouth Neoplasms surgery, Mouth Neoplasms pathology, Head and Neck Neoplasms pathology
- Abstract
Background: Image-guided surgery could help obtain clear (≥5.0 mm) resection margins. This feasibility study investigated ultrasound-guided resection accuracy of buccal mucosa squamous cell carcinoma (BMSCC)., Methods: MRI and ultrasound measurements of tumor thickness were compared to histology in 13 BMSCC-patients. Ultrasound measured margins (at five locations) on the specimen were compared to the corresponding histological margins., Results: Accuracy of in- and ex-vivo ultrasound (mean deviation from histology: 1.6 mm) for measuring tumor thickness was comparable to MRI (mean deviation from histology: 2.6 mm). The sensitivity to detect clear margins using ex-vivo ultrasound was low (48%). If an ex-vivo ultrasound cutoff of ≥7.5 mm would be used, the sensitivity would increase to 86%., Conclusions: Ultrasound-guided resection of BMSCC's is feasible. In- and ex-vivo ultrasound measure tumor thickness in BMSCC accurately. We recommend ≥7.5 mm resection margins on ex-vivo ultrasound to obtain histological clear margins. Additional research is required to establish the effect of 7.5 mm ultrasound cutoff., (© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2023
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7. Diagnostic test accuracy of sentinel lymph node biopsy in squamous cell carcinoma of the oropharynx, larynx, and hypopharynx: A systematic review and meta-analysis.
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van den Bosch S, Czerwinski M, Govers T, Takes RP, de Bree R, Al-Mamgani A, Hannink G, and Kaanders JHAM
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- Diagnostic Tests, Routine, Humans, Hypopharynx pathology, Lymph Nodes pathology, Oropharynx pathology, Quality of Life, Sentinel Lymph Node Biopsy, Squamous Cell Carcinoma of Head and Neck pathology, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms pathology, Larynx pathology
- Abstract
The aim of this meta-analysis was to determine the diagnostic test accuracy of sentinel lymph node biopsy (SLNB) in patients with oropharyngeal, laryngeal, and hypopharyngeal squamous cell carcinoma (SCC). For this purpose, MEDLINE, EMBASE, and Web of Science were searched from inception to March 8, 2022. Included were studies evaluating diagnostic test accuracy of SLNB to identify cervical lymph node metastases with elective neck dissection or follow-up as reference. A bivariate generalized linear mixed model approach was used for the meta-analysis. Nineteen studies were eligible, evaluating 377 cases in total. The pooled estimates of sensitivity and negative predictive value were 0.93 (95% CI: 0.86-0.96) and 0.97 (95% CI: 0.94-0.98), respectively. The excellent accuracy of SLNB justifies a place in the diagnostic workup of patients with larynx and pharynx SCC. Randomized trials are required to demonstrate oncologic safety and benefits on treatment related morbidity and quality of life when omitting elective neck treatment based on SLNB., (© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2022
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8. Association of low skeletal muscle mass and systemic inflammation with surgical complications and survival after microvascular flap reconstruction in patients with head and neck cancer.
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Chargi N, Breik O, Forouzanfar T, Martin T, Praveen P, Idle M, Parmar S, and de Bree R
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- Humans, Inflammation, Muscle, Skeletal, Postoperative Complications epidemiology, Retrospective Studies, Surgical Flaps, Free Tissue Flaps blood supply, Head and Neck Neoplasms surgery, Plastic Surgery Procedures adverse effects
- Abstract
Background: Skeletal muscle mass (SMM) and chronic inflammation are associated with postoperative complications and survival., Methods: Patients with head and neck cancer (HNC) undergoing microvascular free flap reconstruction were included. SMM and neutrophil-to-lymphocyte ratio (NLR) were measured and their association with treatment outcomes analyzed., Results: Five hundred and fifty-four patients were included. Predictors for complications were elevated NLR in all flaps (OR 1.5), low SMM in radial forearm flap (OR 2.0), and elevated NLR combined with low SMM in fibula flap surgery (OR 4.3). Patients with solely elevated NLR were at risk for flap-related complications (OR 3.0), severe complications (OR 2.2), and when combined with low SMM for increased length of hospital stays (LOS) (+3.9 days). In early-stage HNC, low SMM (HR 2.3), and combined elevated NLR with low SMM (HR 2.6) were prognostics for decreased overall survival., Conclusions: SMM and NLR are predictive for poor outcomes in patients with HNC undergoing microvascular reconstruction., (© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2022
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9. Arterial calcification on preoperative computed tomography imaging as a risk factor for pharyngocutaneous fistula formation after total laryngectomy.
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Bril SI, Chargi N, Pezier TF, Tijink BM, Braunius WW, Smid EJ, de Jong PA, and de Bree R
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- Humans, Laryngectomy adverse effects, Postoperative Complications diagnostic imaging, Postoperative Complications epidemiology, Postoperative Complications etiology, Retrospective Studies, Risk Factors, Tomography adverse effects, Tomography, X-Ray Computed, Cutaneous Fistula diagnostic imaging, Cutaneous Fistula epidemiology, Cutaneous Fistula etiology, Laryngeal Neoplasms complications, Laryngeal Neoplasms surgery, Pharyngeal Diseases diagnostic imaging, Pharyngeal Diseases epidemiology, Pharyngeal Diseases etiology
- Abstract
Background: Research in esophageal surgery showed that computed tomography (CT) assessed arterial calcification (AC) is associated with postoperative complications. We investigated the association between AC and pharyngocutaneous fistula (PCF) formation after laryngectomy., Methods: This was a retrospective cohort study of patients undergoing laryngectomy. AC was scored at 10 different anatomical locations on CT imaging, blinded for PCF occurrence. Association with PCF was investigated using logistic regression., Results: The 224 patients were included; 62 (27.7%) developed a PCF. Moderate to severe AC was widespread in patients undergoing TL; 7.1% of patients had at most mild AC, of whom 1 experienced a PCF (p = 0.05). A higher cumulative calcification score was associated with PCF in univariable (OR 1.11, p = 0.04) and multivariable analysis (OR 1.14, p = 0.05)., Conclusion: AC is widespread in patients undergoing laryngectomy and its burden is associated with PCF. Extensive AC on preoperative imaging may be considered a risk factor for PCF., (© 2021 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2022
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10. The association of pretreatment low skeletal muscle mass with chemotherapy dose-limiting toxicity in patients with head and neck cancer undergoing primary chemoradiotherapy with high-dose cisplatin.
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Bril SI, Al-Mamgani A, Chargi N, Remeijer P, Devriese LA, de Boer JP, and de Bree R
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- Antineoplastic Combined Chemotherapy Protocols, Chemoradiotherapy adverse effects, Humans, Muscle, Skeletal, Retrospective Studies, Cisplatin adverse effects, Head and Neck Neoplasms therapy
- Abstract
Background: Low skeletal muscle mass (SMM) is an adverse prognostic factor for chemotherapy dose-limiting toxicity (CDLT). In patients with locally advanced head and neck squamous cell carcinoma (HNSCC) undergoing chemoradiotherapy (CRT), low SMM is a predictor for CDLT. We aimed to validate these findings., Methods: Consecutive LA-HNSCC patients treated with primary CRT with high-dose cisplatin were retrospectively included. SMM was measured on pre-treatment CT-imaging. A cumulative cisplatin dose below 200 mg/m
2 was defined as CDLT., Results: One hundred and fifty three patients were included; 37 (24.2%) experienced CDLT, and 84 had low SMM (54.9%). Patients with low SMM experienced more CDLT than patients with normal SMM (35.7% vs. 10.1%, p < 0.01). Low SMM (OR 3.99 [95% CI 1.56-10.23], p = 0.01) and an eGFR of 60-70 ml/min (OR 5.40 [95% CI 1.57-18.65], p < 0.01) were predictors for CDLT., Conclusion: Pre-treatment low SMM is associated with CDLT in LA-HNSCC patients treated with primary CRT. Routine SMM assessment may allow for CDLT risk assessment and treatment optimization., (© 2021 The Authors. Head & Neck published by Wiley Periodicals LLC.)- Published
- 2022
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11. Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic review and meta-analysis.
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Smits HJG, Assili S, Kauw F, Philippens MEP, de Bree R, and Dankbaar JW
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- Chemoradiotherapy, Humans, Neoplasm Staging, Prognosis, Hypopharyngeal Neoplasms diagnostic imaging, Hypopharyngeal Neoplasms pathology, Hypopharyngeal Neoplasms therapy, Larynx pathology
- Abstract
Background: In this systematic review, we aim to identify prognostic imaging variables of recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy., Methods: A systematic search was performed in PubMed and EMBASE (1990-2020). The crude data and effect estimates were extracted for each imaging variable. The level of evidence of each variable was assessed and pooled risk ratios (RRs) were calculated., Results: Twenty-two articles were included in this review, 17 on computed tomography (CT) and 5 on magnetic resonance imaging (MRI) variables. We found strong evidence for the prognostic value of tumor volume at various cut-off points (pooled RRs ranging from 2.09 to 3.03). Anterior commissure involvement (pooled RR 2.19), posterior commissure involvement (pooled RR 2.44), subglottic extension (pooled RR 2.25), and arytenoid cartilage extension (pooled RR 2.10) were also strong prognostic factors., Conclusion: Pretreatment tumor volume and involvement of several subsites are prognostic factors for recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy., (© 2021 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2021
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12. Contemporary management of the neck in nasopharyngeal carcinoma.
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Ng WT, Tsang RKY, Beitler JJ, de Bree R, Coca-Pelaz A, Eisbruch A, Guntinas-Lichius O, Lee AWM, Mäkitie AA, Mendenhall WM, Nuyts S, Rinaldo A, Robbins KT, Rodrigo JP, Silver CE, Simo R, Smee R, Strojan P, Takes RP, and Ferlito A
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- Humans, Lymphatic Metastasis, Nasopharyngeal Carcinoma radiotherapy, Neck pathology, Neoplasm Staging, Carcinoma therapy, Nasopharyngeal Neoplasms pathology, Nasopharyngeal Neoplasms radiotherapy
- Abstract
Up to 85% of the patients with nasopharyngeal carcinoma present with regional nodal metastasis. Although excellent nodal control is achieved with radiotherapy, a thorough understanding of the current TNM staging criteria and pattern of nodal spread is essential to optimize target delineation and minimize unnecessary irradiation to adjacent normal tissue. Selective nodal irradiation with sparing of the lower neck and submandibular region according to individual nodal risk is now emerging as the preferred treatment option. There has also been continual refinement in staging classification by incorporating relevant adverse nodal features. As for the uncommon occurrence of recurrent nodal metastasis after radiotherapy, surgery remains the standard of care., (© 2021 Wiley Periodicals LLC.)
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- 2021
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13. Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review.
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Guntinas-Lichius O, Thielker J, Robbins KT, Olsen KD, Shaha AR, Mäkitie AA, de Bree R, Vander Poorten V, Quer M, Rinaldo A, Kowalski LP, Rodrigo JP, Hamoir M, and Ferlito A
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- Adult, Humans, Lymph Nodes pathology, Lymphatic Metastasis, Neoplasm Recurrence, Local pathology, Neoplasm Staging, Prognosis, Retrospective Studies, Parotid Neoplasms pathology
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Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear., Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review., Results: The pooled prevalence of the P in adult patients in the unselected studies was 24.10% (95% confidence interval = 17.95-30.25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P- patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P- was 2.67 ± 0.58., Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning., (© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.)
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- 2021
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14. HIF-1a expression and differential effects on survival in patients with oral cavity, larynx, and oropharynx squamous cell carcinomas.
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Swartz JE, Wegner I, Noorlag R, van Kempen PMW, van Es RJJ, de Bree R, and Willems SMW
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- Humans, Larynx, Mouth, Oropharynx, Prognosis, Squamous Cell Carcinoma of Head and Neck, Survival Rate, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypoxia-Inducible Factor 1, alpha Subunit genetics
- Abstract
Background: Hypoxia is a negative prognostic factor in head and neck squamous cell carcinomas. Under hypoxia, the hypoxia-inducible factor (HIF)-1a transcription factor is overexpressed. We investigated whether there were site differences in HIF-1a expression and its effect on patient outcomes per subsite., Design/method: A total of 941 patients with HNSCC in the squamous cell carcinoma of the oropharynx (OPSCC, n = 302), oral cavity (OSCC, n = 391), or larynx (LSCC, n = 248) were included. Expression of HIF-1a in tissue samples was investigated using immunohistochemistry. Overall survival (OS), disease-free survival (DFS), and locoregional control (LRC) were analyzed., Results: HIF-1a expression was higher in OSCC than in LSCC and OPSCC. High HIF-1a expression led to worse prognosis in OPSCC (OS P = .029, DFS P = .085) and LSCC (OS P = .041, DFS P = .011) and better in OSCC (OS P = .055, DFS P = .012). There was no association between HIF-1a and LRC., Conclusions: High HIF-1a expression is related to poor outcome in OPSCC and LSCC and better outcome in OSCC., (© 2020 Wiley Periodicals LLC.)
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- 2021
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15. Oral squamous cell carcinoma involving the maxillae: Factors affecting local recurrence and the value of salvage treatment for overall survival.
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Slieker FJB, de Bree R, and Van Cann EM
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- Humans, Maxilla, Neoplasm Recurrence, Local, Prognosis, Retrospective Studies, Salvage Therapy, Squamous Cell Carcinoma of Head and Neck, Treatment Outcome, Carcinoma, Squamous Cell surgery, Head and Neck Neoplasms, Mouth Neoplasms surgery
- Abstract
Objective: To determine factors associated with local recurrence (LR) of oral squamous cell carcinoma involving the maxillae (MSCC) and overall survival (OS) after salvage treatment., Subjects and Methods: Retrospective study of MSCC operated between 2000 and 2015. Kaplan-Meier survival and Cox regression were used for analysis of MSCC-associated clinical and histopathological factors., Results: Ninety-five patients were included. LR occurred in 24% of patients. Vascular invasion significantly increased the risk of LR (hazard ratio 4.595, P = .003). Local salvage surgery, in the area of the original tumor, significantly prolonged OS, compared to palliative treatment (P = .001) and extensive salvage surgery (P = .013). Extensive salvage surgery, requiring resection of adjacent facial structures, did not prolong OS compared to palliative treatment (P = .186)., Conclusions: MSCC with vascular invasion has higher risk of LR. Salvage surgery may prolong OS in small recurrences but might have dubious value for larger recurrences infiltrating adjacent facial structures., (© 2020 The Authors. Head & Neck published by Wiley Periodicals, Inc.)
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- 2020
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16. COVID-19 pandemic: Effects and evidence-based recommendations for otolaryngology and head and neck surgery practice.
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Kowalski LP, Sanabria A, Ridge JA, Ng WT, de Bree R, Rinaldo A, Takes RP, Mäkitie AA, Carvalho AL, Bradford CR, Paleri V, Hartl DM, Vander Poorten V, Nixon IJ, Piazza C, Lacy PD, Rodrigo JP, Guntinas-Lichius O, Mendenhall WM, D'Cruz A, Lee AWM, and Ferlito A
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- COVID-19, Coronavirus Infections epidemiology, Humans, Pneumonia, Viral epidemiology, Practice Guidelines as Topic, Practice Patterns, Physicians', SARS-CoV-2, Betacoronavirus, Coronavirus Infections prevention & control, Coronavirus Infections transmission, Infectious Disease Transmission, Patient-to-Professional prevention & control, Otolaryngology, Pandemics prevention & control, Pneumonia, Viral prevention & control, Pneumonia, Viral transmission
- Abstract
The 2019 novel coronavirus disease (COVID-19) is a highly contagious zoonosis produced by SARS-CoV-2 that is spread human-to-human by respiratory secretions. It was declared by the WHO as a public health emergency. The most susceptible populations, needing mechanical ventilation, are the elderly and people with associated comorbidities. There is an important risk of contagion for anesthetists, dentists, head and neck surgeons, maxillofacial surgeons, ophthalmologists, and otolaryngologists. Health workers represent between 3.8% and 20% of the infected population; some 15% will develop severe complaints and among them, many will lose their lives. A large number of patients do not have overt signs and symptoms (fever/respiratory), yet pose a real risk to surgeons (who should know this fact and must therefore apply respiratory protective strategies for all patients they encounter). All interventions that have the potential to aerosolize aerodigestive secretions should be avoided or used only when mandatory. Health workers who are: pregnant, over 55 to 65 years of age, with a history of chronic diseases (uncontrolled hypertension, diabetes mellitus, chronic obstructive pulmonary diseases, and all clinical scenarios where immunosuppression is feasible, including that induced to treat chronic inflammatory conditions and organ transplants) should avoid the clinical attention of a potentially infected patient. Health care facilities should prioritize urgent and emergency visits and procedures until the present condition stabilizes; truly elective care should cease and discussed on a case-by-case basis for patients with cancer. For those who are working with COVID-19 infected patients' isolation is compulsory in the following settings: (a) unprotected close contact with COVID-19 pneumonia patients; (b) onset of fever, cough, shortness of breath, and other symptoms (gastrointestinal complaints, anosmia, and dysgeusia have been reported in a minority of cases). For any care or intervention in the upper aerodigestive tract region, irrespective of the setting and a confirmed diagnosis (eg, rhinoscopy or flexible laryngoscopy in the outpatient setting and tracheostomy or rigid endoscopy under anesthesia), it is strongly recommended that all health care personnel wear personal protective equipment such as N95, gown, cap, eye protection, and gloves. The procedures described are essential in trying to maintain safety of health care workers during COVID-19 pandemic. In particular, otolaryngologists, head and neck, and maxillofacial surgeons are per se exposed to the greatest risk of infection while caring for COVID-19 positive subjects, and their protection should be considered a priority in the present circumstances., (© 2020 Wiley Periodicals, Inc.)
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- 2020
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17. The risk of second primary tumors in head and neck cancer: A systematic review.
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Coca-Pelaz A, Rodrigo JP, Suárez C, Nixon IJ, Mäkitie A, Sanabria A, Quer M, Strojan P, Bradford CR, Kowalski LP, Shaha AR, de Bree R, Hartl DM, Rinaldo A, Takes RP, and Ferlito A
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- Esophagus, Humans, Incidence, Prognosis, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms therapy, Neoplasms, Second Primary epidemiology
- Abstract
Background: Second primary tumors (SPTs) are a common cause of reduced life expectancy in patients treated for head and neck cancer (HNC). This phenomenon forms an area to be addressed during posttreatment follow-up., Methods: We conducted a systematic review of literature following PRISMA guidelines, from 1979 to 2019, to investigate incidence of SPTs, synchronous, and metachronous, in HNC population., Results: Our review includes data of 456 130 patients from 61 articles. With a minimum follow-up of 22 months, mean incidence of SPTs was 13.2% (95% CI: 11.56-14.84): 5.3% (95% CI: 4.24-6.36) for synchronous SPTs and 9.4% (95% CI: 7.9-10.9) for metachronous SPTs. The most frequent site for SPTs was head and neck area, followed by the lungs and esophagus., Conclusion: Although with wide variations between studies, the rate of SPTs in HNC patients is high. Given the impact in the prognosis, we must develop strategies for the early diagnosis of SPTs., (© 2019 Wiley Periodicals, Inc.)
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- 2020
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18. Predicting individualized mortality probabilities for patients with squamous cell carcinoma of the maxilla: Novel models with clinical and histopathological predictors.
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Slieker FJB, de Bree R, and Van Cann EM
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- Carcinoma, Squamous Cell surgery, Cohort Studies, Databases, Factual, Disease-Free Survival, Female, Follow-Up Studies, Humans, Logistic Models, Male, Maxillary Neoplasms surgery, Multivariate Analysis, Neoplasm Invasiveness pathology, Neoplasm Staging, Oral Surgical Procedures methods, Predictive Value of Tests, Probability, Proportional Hazards Models, Radiotherapy, Adjuvant, Retrospective Studies, Survival Analysis, Time Factors, Treatment Outcome, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Maxillary Neoplasms mortality, Maxillary Neoplasms pathology
- Abstract
Background: The aim of this article was to develop prediction models that calculate postoperative 2- and 5-year mortality probabilities of patients with squamous cell carcinoma of the maxilla (MSCC)., Methods: Data were collected from the medical records of patients who had been operated between 2000 and 2015 for MSCC. Potential clinical and histopathological predictors were identified. Confounding-(un)adjusted multivariate Cox and logistic regression models were computed with stepwise backward selection. Internal validation was performed to assess calibration and discriminatory ability., Results: Ninety-five patients with MSCC were included. Two-year follow-up was complete, and 85 patients had 5-year follow-up. Age, neck treatment, surgical margins, bone invasion, spindle growth, and vasoinvasive growth were associated with mortality. Models were adjusted for confounding with Charlson's comorbidities index. C-indexes were .841 and .770 respectively, and .838 and .749 after bootstrapping., Conclusion: The MSCC-specific mortality probability can be calculated with new prediction models., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
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19. Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer.
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Schilling C, Stoeckli SJ, Vigili MG, de Bree R, Lai SY, Alvarez J, Christensen A, Cognetti DM, D'Cruz AK, Frerich B, Garrel R, Kohno N, Klop WM, Kerawala C, Lawson G, McMahon J, Sassoon I, Shaw RJ, Tvedskov JF, von Buchwald C, and McGurk M
- Subjects
- Humans, Lymph Nodes physiopathology, Mouth Neoplasms pathology, Mouth Neoplasms radiotherapy, Neoplasm Staging standards, Radiotherapy, Adjuvant, Lymph Nodes pathology, Mouth Neoplasms surgery, Neoplasm Staging methods, Sentinel Lymph Node Biopsy standards
- Abstract
Background: The eighth international symposium for sentinel node biopsy (SNB) in head and neck cancer was held in 2018. This consensus conference aimed to deliver current multidisciplinary guidelines. This document focuses on the surgical aspects of SNB for oral cancer., Method: Invited expert faculty selected topics requiring guidelines. Topics were reviewed and evidence evaluated where available. Data were presented at the consensus meeting, with live debate from panels comprising expert, nonexpert, and patient representatives followed by voting to assess the level of support for proposed recommendations. Evidence review, debate, and voting results were all considered in constructing these guidelines., Results/conclusion: A range of topics were considered, from patient selection to surgical technique and follow-up schedule. Consensus was not achieved in all areas, highlighting potential issues that would benefit from prospective studies. Nevertheless these guidelines represent an up-to-date pragmatic recommendation based on current evidence and expert opinion., (© 2019 Wiley Periodicals, Inc.)
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- 2019
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20. The role of age in treatment-related adverse events in patients with head and neck cancer: A systematic review.
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Coca-Pelaz A, Halmos GB, Strojan P, de Bree R, Bossi P, Bradford CR, Rinaldo A, Vander Poorten V, Sanabria A, Takes RP, and Ferlito A
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- Age Factors, Aged, Carcinoma, Squamous Cell mortality, Comorbidity, Enhanced Recovery After Surgery, Frailty, Geriatric Assessment, Head and Neck Neoplasms mortality, Humans, Neoplasm Metastasis, Neoplasm Recurrence, Local, Operative Time, Patient Selection, Prognosis, Social Support, Carcinoma, Squamous Cell therapy, Combined Modality Therapy adverse effects, Head and Neck Neoplasms therapy, Postoperative Complications
- Abstract
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed in advanced stage and therefore requires aggressive, multimodal treatment. Elderly patients are often excluded from standard therapy regimens purely based on age. This clinical review aims to collect all published data in the literature on treatment modality selection in elderly patients and on age-related adverse events following treatment of HNSCC. We performed a literature search for articles on the treatment of HNSCC in elderly patients. Most of the articles were retrospective studies with the consequent limitations. It can be concluded that age is not an absolute contraindication for intensive treatment and comorbidity is an important predictor of outcome, but not the only one. Despite the existence of multiple tools for pretreatment evaluation, there are not consistent data on their use., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
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21. Depth of invasion in patients with early stage oral cancer staged by sentinel node biopsy.
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den Toom IJ, Janssen LM, van Es RJJ, Karagozoglu KH, de Keizer B, van Weert S, Willems SM, Bloemena E, Leemans CR, and de Bree R
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- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasm Invasiveness, Sensitivity and Specificity, Carcinoma, Squamous Cell pathology, Mouth Neoplasms pathology, Neoplasm Metastasis diagnosis, Sentinel Lymph Node Biopsy
- Abstract
Background: To investigate if depth of invasion (DOI) can predict occult nodal disease in patients with cT1-2N0 (7th TNM) oral squamous cell carcinoma (OSCC) staged by sentinel lymph node biopsy (SLNB)., Methods: In 199 OSCC patients, DOI measurements and SLNB were performed., Results: Metastases were found in 64 of 199 patients (32%). Of these 64 patients, the mean DOI was 6.6 mm compared to 4.7 mm in patients without metastases (P = .003). The ROC-curve showed an area under the curve of 0.65 with a most optimal cutoff point of 3.4 mm DOI (sensitivity 83% and specificity 47%). Regional metastases were found in 15% of patients with DOI ≤ 3.4 mm., Conclusion: DOI seems to be a poor predictor for regional metastasis in patients with cT1-2N0 OSCC. Therefore, staging of the neck using SLNB in patients with early stage oral cancer should also be performed in tumors with limited DOI and probably in T3 (8th TNM) OSCC ≤4 cm diameter., (© 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc.)
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- 2019
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22. Preoperative low skeletal muscle mass as a risk factor for pharyngocutaneous fistula and decreased overall survival in patients undergoing total laryngectomy.
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Bril SI, Pezier TF, Tijink BM, Janssen LM, Braunius WW, and de Bree R
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- Aged, Body Mass Index, Female, Humans, Laryngeal Neoplasms mortality, Laryngeal Neoplasms pathology, Length of Stay, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Risk Factors, Survival Rate, Cutaneous Fistula epidemiology, Laryngeal Neoplasms surgery, Laryngectomy adverse effects, Muscle, Skeletal, Pharyngeal Diseases epidemiology, Postoperative Complications epidemiology
- Abstract
Background: Low skeletal muscle mass (SMM) is associated with postoperative complications, prolonged hospital stay, and short overall survival (OS) in surgical oncology. We aimed to investigate this association in patients undergoing total laryngectomy (TL)., Methods: A retrospective study was performed of patients undergoing TL. SMM was measured using CT or MRI scans at the level of the third cervical vertebra (C3)., Results: In all, 235 patients were included. Low SMM was observed in 109 patients (46.4%). Patients with low SMM had more pharyngocutaneous fistulas (PCFs) than patients with normal SMM (34.9% vs 20.6%; P = .02) and prolonged hospital stay (median, 17 vs 14 days; P < .001). In multivariate analysis, low SMM (hazards ratio, 1.849; 95% confidence interval, 1.202-2.843) and high N stage were significant prognosticators of decreased OS., Conclusion: Low SMM is associated with PCF and prolonged hospital stay in patients undergoing TL. Low SMM is an independent prognostic factor for shorter OS., (© 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc.)
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- 2019
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23. Contemporary management of primary parapharyngeal space tumors.
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López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, and Ferlito A
- Subjects
- Humans, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms therapy, Parapharyngeal Space
- Abstract
The parapharyngeal space is a complex anatomical area. Primary parapharyngeal tumors are rare tumors and 80% of them are benign. A variety of tumor types can develop in this location; most common are salivary gland neoplasm and neurogenic tumors. The management of these tumors has improved greatly owing to the developments in imaging techniques, surgery, and radiotherapy. Most tumors can be removed with a low rate of complications and recurrence. The transcervical approach is the most frequently used. In some cases, minimally invasive approaches may be used alone or in combination with a limited transcervical route, allowing large tumors to be removed by reducing morbidity of expanded approaches. An adequate knowledge of the anatomy and a careful surgical plan is essential to tailor management according to the patient and the tumor. The purpose of the present review was to update current aspects of knowledge related to this more challenging area of tumor occurrence., (© 2018 Wiley Periodicals, Inc.)
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- 2019
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24. Differences in cancer gene copy number alterations between Epstein-Barr virus-positive and Epstein-Barr virus-negative nasopharyngeal carcinoma.
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Ooft ML, van Ipenburg J, van de Loo RJM, de Jong R, Moelans CB, de Bree R, de Herdt MJ Ir, Koljenović S, Baatenburg de Jong R, Hardillo J, and Willems SM
- Subjects
- Adult, Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Nasopharyngeal Carcinoma mortality, Nasopharyngeal Neoplasms mortality, DNA Copy Number Variations, Epstein-Barr Virus Infections complications, Nasopharyngeal Carcinoma genetics, Nasopharyngeal Carcinoma virology, Nasopharyngeal Neoplasms genetics, Nasopharyngeal Neoplasms virology
- Abstract
Background: Nasopharyngeal carcinoma (NPC) treatment is mainly based on clinical staging. We hypothesize that better understanding of the molecular heterogeneity of NPC can aid in better treatment decisions. Therefore, the purpose of this study was to present our exploration of cancer gene copy-number alterations (CNAs) of Epstein-Barr virus (EBV)-positive and EBV-negative NPC., Methods: Multiplex ligation-dependent probe amplification was applied to detect CNAs of 36 cancer genes (n = 103). Correlation between CNAs, clinicopathological features, and survival were examined., Results: The CNAs occurred significantly more in EBV-negative NPC, with PIK3CA and MCCC1 (P < .001) gain/amplification occurring more frequently. Gain/amplification of cyclin-L1 (CCNL1) and PTK2 (P < .001) predict worse disease-free survival (DFS) in EBV-positive NPC., Conclusion: The EBV-positive and EBV-negative NPC show some similarities in cancer gene CNAs suggesting a common pathogenic route but also important differences possibly indicating divergence in oncogenesis. Copy number gain/amplification of CCNL1 and PTK2 are possibly good predictors of survival in EBV-positive NPC., (© 2018 Wiley Periodicals, Inc.)
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- 2018
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25. Sacrifice and extracranial reconstruction of the common or internal carotid artery in advanced head and neck carcinoma: Review and meta-analysis.
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Bäck LJJ, Aro K, Tapiovaara L, Vikatmaa P, de Bree R, Fernández-Álvarez V, Kowalski LP, Nixon IJ, Rinaldo A, Rodrigo JP, Robbins KT, Silver CE, Snyderman CH, Suárez C, Takes RP, and Ferlito A
- Subjects
- Aged, Aged, 80 and over, Carotid Artery, Common pathology, Carotid Artery, Internal pathology, Disease-Free Survival, Female, Head and Neck Neoplasms mortality, Head and Neck Neoplasms surgery, Humans, Male, Middle Aged, Neoplasm Invasiveness pathology, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Risk Assessment, Survival Analysis, Carotid Artery, Common surgery, Carotid Artery, Internal surgery, Head and Neck Neoplasms pathology, Plastic Surgery Procedures methods
- Abstract
Background: Sacrifice and reconstruction of the carotid artery in cases of head and neck carcinoma with invasion of the common or internal carotid artery is debated., Methods: We conducted a systematic search of electronic databases and provide a review and meta-analysis., Results: Of the 72 articles identified, 24 met the inclusion criteria resulting in the inclusion of 357 patients. The overall perioperative 30-day mortality was 3.6% (13/357). Permanent cerebrovascular complications occurred in 3.6% (13/357). Carotid blowout episodes were encountered in 1.4% (5/357). The meta-regression analysis showed a significant difference in 1-year overall survival between reports published from 1981-1999 (37.0%) and 2001-2016 (65.4%; P = .02)., Conclusion: This review provides evidence that sacrifice with extracranial reconstruction of common or internal carotid artery in selected patients with head and neck carcinoma may improve survival with acceptable complication rates. However, all of the published literature is retrospective involving selected series and, therefore, precludes determining the absolute effectiveness of the surgery., (© 2018 Wiley Periodicals, Inc.)
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- 2018
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26. Prognostic value of lymph node ratio in head and neck squamous cell carcinoma.
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Talmi YP, Takes RP, Alon EE, Nixon IJ, López F, de Bree R, Rodrigo JP, Shaha AR, Halmos GB, Rinaldo A, and Ferlito A
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- Head and Neck Neoplasms mortality, Head and Neck Neoplasms surgery, Humans, Lymph Node Excision, Lymphatic Metastasis, Neoplasm Staging, Prognosis, Squamous Cell Carcinoma of Head and Neck mortality, Squamous Cell Carcinoma of Head and Neck surgery, Head and Neck Neoplasms pathology, Squamous Cell Carcinoma of Head and Neck pathology
- Abstract
Background: Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (HNSCC)., Methods: A PubMed internet search was performed and articles meeting selection criteria were reviewed., Results: Twenty-eight studies were identified in the literature dealing with the prognostic value of LNR. The published results are variable with a range of cutoff values of LNR associated with prognosis (overall survival [OS] and/or disease-specific survival [DSS]) between 0.02 and 0.20, with an average of 0.09., Conclusion: The LNR is reported to be of value in assessing prognosis in the patients with HNSCC. Although it is easy to calculate and could be considered in the staging of these patients, the currently available evidence in the literature does not yet provide a solid base for implementation., (© 2018 Wiley Periodicals, Inc.)
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- 2018
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27. Response assessment after induction chemotherapy for head and neck squamous cell carcinoma: From physical examination to modern imaging techniques and beyond.
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de Bree R, Wolf GT, de Keizer B, Nixon IJ, Hartl DM, Forastiere AA, Haigentz M Jr, Rinaldo A, Rodrigo JP, Saba NF, Suárez C, Vermorken JB, and Ferlito A
- Subjects
- Carcinoma, Squamous Cell drug therapy, Diffusion Magnetic Resonance Imaging, Fluorodeoxyglucose F18, Head and Neck Neoplasms drug therapy, Humans, Positron-Emission Tomography, Squamous Cell Carcinoma of Head and Neck, Tomography, X-Ray Computed, Treatment Outcome, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms diagnostic imaging, Head and Neck Neoplasms pathology, Induction Chemotherapy
- Abstract
Significant correlations between the response to induction chemotherapy and success of subsequent radiotherapy have been reported and suggest that the response to induction chemotherapy is able to predict a response to radiotherapy. Therefore, induction chemotherapy may be used to tailor the treatment plan to the individual patient with head and neck cancer: following the planned subsequent (chemo)radiation schedule, planning a radiation dose boost, or reassessing the modality of treatment (eg, upfront surgery). Findings from reported trials suggest room for improvement in clinical response assessment after induction chemotherapy, but an optimal method has yet to be identified. Historically, indices of treatment efficacy in solid tumors have been based solely on systematic assessment of tumor size. However, functional imaging (eg, fluorodeoxyglucose-positron emission tomography (FDG-PET) potentially provides an earlier indication of response to treatment than conventional imaging techniques. More advanced imaging techniques are still in an exploratory phase and are not ready for use in clinical practice., (© 2017 The Authors Head & Neck Published by Wiley Periodicals, Inc.)
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- 2017
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28. Cytokeratin 19 expression in early oral squamous cell carcinoma and their metastasis: Inadequate biomarker for one-step nucleic acid amplification implementation in sentinel lymph node biopsy procedure.
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Noorlag R, van Es RJJ, de Bree R, and Willems SM
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- Adult, Aged, Biopsy, Needle, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell surgery, Cohort Studies, Disease-Free Survival, Female, Humans, Immunohistochemistry, Lymphatic Metastasis, Male, Middle Aged, Mouth Neoplasms metabolism, Mouth Neoplasms mortality, Neoplasm Invasiveness pathology, Neoplasm Staging, Nucleic Acid Amplification Techniques, Prognosis, Retrospective Studies, Risk Assessment, Survival Analysis, Biomarkers, Tumor metabolism, Carcinoma, Squamous Cell pathology, Keratin-19 metabolism, Mouth Neoplasms pathology, Sentinel Lymph Node Biopsy
- Abstract
Background: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step nucleic acid amplification rapidly detects cytokeratin 19 (CK19) RNA with high accuracy. Sensitivity and specificity of CK19 expression in OSCC was evaluated., Methods: Immunohistochemical CK19 expression was done in 207 patients with OSCC with 65 cases of paired nodal metastases., Results: CK19 was expressed in 65% of all OSCC and even less in early OSCC (56%), with poor correlation between primary tumor and (occult) nodal metastasis. Furthermore, ectopic glandular tissue in close proximity of lymph nodes showed strong CK19 expression., Conclusion: CK19 lacks both sensitivity and specificity as a biomarker for nodal metastasis in OSCC, which questions the suitability for CK19-based one-step nucleic acid amplification in SLNB procedures. Therefore, future studies should focus on other biomarkers, because the concept of fast intraoperative diagnostics during SLNB remains attractive., (© 2017 Wiley Periodicals, Inc.)
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- 2017
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29. Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults.
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Boon E, van der Graaf WT, Gelderblom H, Tesselaar ME, van Es RJ, Oosting SF, de Bree R, van Meerten E, Hoeben A, Smeele LE, Willems SM, Witjes MJ, Buter J, Baatenburg de Jong RJ, Flucke UE, Peer PG, Bovée JV, and Van Herpen CM
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Chemotherapy, Adjuvant, Female, Head and Neck Neoplasms mortality, Humans, Male, Middle Aged, Neoadjuvant Therapy, Netherlands, Osteosarcoma mortality, Retrospective Studies, Survival Rate, Young Adult, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms surgery, Neoplasm Recurrence, Local epidemiology, Osteosarcoma drug therapy, Osteosarcoma surgery
- Abstract
Background: There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck., Methods: All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed., Results: We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively)., Conclusion: In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 140-146, 2017., (© 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc.)
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- 2017
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30. Shoulder morbidity after pectoralis major flap reconstruction.
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Refos JW, Witte BI, de Goede CJ, and de Bree R
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- Adult, Aged, Cross-Sectional Studies, Female, Follow-Up Studies, Head and Neck Neoplasms parasitology, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Myocutaneous Flap blood supply, Netherlands, Pain Measurement, Pectoralis Muscles transplantation, Range of Motion, Articular physiology, Plastic Surgery Procedures methods, Risk Assessment, Shoulder Joint physiopathology, Shoulder Pain physiopathology, Statistics, Nonparametric, Head and Neck Neoplasms surgery, Myocutaneous Flap transplantation, Neck Dissection methods, Pectoralis Muscles surgery, Plastic Surgery Procedures adverse effects, Shoulder Pain etiology
- Abstract
Background: Donor site morbidity of pectoralis major pedicled flap (PMPF) is scarcely studied., Methods: A cross-sectional study on patients who underwent reconstructive surgery with a PMPF at least 6 months before was performed. Patients with a similar type neck dissection on both sides and PMPF on one side (n = 9) were assigned to group 1; patients with neck dissection and PMPF (n = 26) were assigned to group 2; and neck dissection only (n = 47) were assigned to group 3. All 3 groups filled out a shoulder disability questionnaire and underwent shoulder function tests. Pain of the shoulder was rated on a visual analog scale (VAS). Patients were also asked if they had experienced stiffness of the shoulder during the previous week. Range of motion (ROM) of the shoulder was examined by one single examiner using an inclinometer, in accord with a standardized protocol. Radical neck dissection (RND), modified radical neck dissection (MRND), and selective neck dissection (SND) sides were separately analyzed., Results: In group 2, shoulder morbidity was experienced more often (p = .065) than in group 3, particularly at the sides where an SND was performed (p = .010). Significant differences in prevalence of shoulder stiffness between PMPF and neck dissection sides and neck dissection only sides were found in the RND (p = .001) and MRND (p = .004) groups, but not in the SND group. A lower ROM of abduction (p = .026) was found in group 2 as compared to group 3., Conclusion: Patients frequently have additional shoulder morbidity after PMPF harvest, particularly after SND. PMPF harvest adds to impairment of abduction. © 2016 Wiley Periodicals, Inc. Head Neck 38:1221-1228, 2016., (© 2016 Wiley Periodicals, Inc.)
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- 2016
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31. Interaction of quantitative (18)F-FDG-PET-CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma.
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Schouten CS, Hakim S, Boellaard R, Bloemena E, Doornaert PA, Witte BI, Braakhuis BJ, Brakenhoff RH, Leemans CR, Hoekstra OS, and de Bree R
- Subjects
- Aged, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell virology, Female, Fluorodeoxyglucose F18, Head and Neck Neoplasms pathology, Head and Neck Neoplasms virology, Humans, Immunohistochemistry, Male, Middle Aged, Oropharyngeal Neoplasms pathology, Oropharyngeal Neoplasms virology, Papillomavirus Infections pathology, Papillomavirus Infections virology, Radiopharmaceuticals, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell diagnostic imaging, Head and Neck Neoplasms diagnostic imaging, Oropharyngeal Neoplasms diagnostic imaging, Papillomaviridae, Papillomavirus Infections diagnostic imaging, Positron Emission Tomography Computed Tomography methods
- Abstract
Background: Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) have a better survival than with HPV-negative oropharyngeal SCC. An (18) F-fluorodeoxyglucose positron emission tomography-CT ((18) F-FDG-PET-CT) may also provide prognostic information. We evaluated glycolytic characteristics in HPV-negative and HPV-positive oropharyngeal SCC., Methods: Forty-four patients underwent pretreatment (18) F-FDG-PET-CT. Standardized uptake values (SUVs) and metabolic active tumor volumes (MATVs) were determined for primary tumors. HPV status was determined with p16 immunostaining, followed by high-risk HPV DNA detection on the positive cases., Results: Twenty-seven patients were HPV-positive (61.4%). Median MATV was 2.8 mL (range = 1.6-5.1 mL) for HPV-positive and 6.0 mL (range = 4.4-18.7 mL) for HPV-negative tumors (p < .001). SUV values are volume dependent (partial volume effect), therefore, MATV was included as covariate in multivariate analysis. In this multivariate analysis, the maximum SUV in HPV-positive tumors was 3.9 units lower than in HPV-negative tumors (p = .01)., Conclusion: The (18) F-FDG-PET-CT parameters are lower in HPV-positive than in HPV-negative patients. Low pretreatment SUV values in HPV-positive oropharyngeal SCC may be at least partly explained by HPV-induced tumor changes., (© 2015 Wiley Periodicals, Inc.)
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- 2016
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32. Radiologic extranodal spread and matted nodes: Important predictive factors for development of distant metastases in patients with high-risk head and neck cancer.
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de Bree R, Ljumanovic R, Hazewinkel MJ, Witte BI, and Castelijns JA
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- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Magnetic Resonance Imaging, Male, Middle Aged, Proportional Hazards Models, Radiography, Retrospective Studies, Risk Factors, Head and Neck Neoplasms diagnostic imaging, Head and Neck Neoplasms pathology, Lymph Nodes pathology, Lymphatic Metastasis diagnosis
- Abstract
Background: Different clinical high-risk factors for the development of distant metastases have been identified but not tested in the same cohort of patients with head and neck squamous cell carcinoma (HNSCC)., Methods: In 145 patients with previously identified clinical high risk factors, the presence of extranodal spread (ENS) and matted node on pretreatment CT (n = 96) and/or MRI (n = 111) were determined., Results: Of 145 patients, ENS was detected in 87 patients (60.0%) and matted nodes in 53 patients (36.6%). Kaplan-Meier curves for presence or absence of ENS (on CT and/or MRI) and matted nodes (on CT) differ significantly. In a Cox regression analysis, only ENS was a significant risk factor (hazard ratio [HR] = 3.3; 95% confidence interval [CI] = 2.0-5.5; p < .001)., Conclusion: In patients with high-risk HNSCC with clinically (palpably or radiologically) ENS and matted nodes, both determined radiologically, are high risk factors for development of distant metastases. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1452-E1458, 2016., (© 2015 Wiley Periodicals, Inc.)
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- 2016
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33. Update on primary head and neck mucosal melanoma.
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López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M Jr, Strojan P, Pellitteri PK, Bradford CR, Shaha AR, Hunt JL, de Bree R, Takes RP, Rinaldo A, and Ferlito A
- Subjects
- Combined Modality Therapy, Head and Neck Neoplasms mortality, Head and Neck Neoplasms pathology, Humans, Melanoma mortality, Melanoma pathology, Mouth Neoplasms therapy, Neoplasm Recurrence, Local prevention & control, Neoplasm Staging, Nose Neoplasms therapy, Paranasal Sinus Neoplasms therapy, Prognosis, Risk Factors, Treatment Outcome, Head and Neck Neoplasms therapy, Melanoma therapy
- Abstract
Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The mainstay of treatment is radical surgical resection followed by adjuvant radiotherapy in selected patients with high-risk features. Multimodality therapy has not been well studied and is not standardized. Adjuvant radiotherapy seems to improve locoregional control but does not improve overall survival (OS). Elective neck dissection is advocated in patients with oral PMM. Systemic therapy should be considered only for patients with metastatic or unresectable locoregional disease. Despite improvements in the field of surgery, radiotherapy, and systemic therapy, patients with PMM still face a very unfavorable prognosis (5-year disease-free survival [DFS] <20%) with high rates of locoregional recurrence and distant metastasis. The present review aims to summarize the current state of knowledge on the molecular biology, pathological diagnosis, and management of this disease., (© 2015 Wiley Periodicals, Inc.)
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- 2016
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34. Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma.
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de Bree R, Takes RP, Castelijns JA, Medina JE, Stoeckli SJ, Mancuso AA, Hunt JL, Rodrigo JP, Triantafyllou A, Teymoortash A, Civantos FJ, Rinaldo A, Pitman KT, Hamoir M, Robbins KT, Silver CE, Hoekstra OS, and Ferlito A
- Subjects
- Humans, Lymphatic Metastasis, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms pathology, Neck Dissection methods, Sentinel Lymph Node Biopsy methods, Ultrasonography, Interventional
- Abstract
Regional metastasis is a prominent feature of head and neck squamous cell carcinoma (HNSCC) and is an important prognostic factor. The currently available imaging techniques for assessment of the neck have limitations in accuracy; thus, elective neck dissection has remained the usual choice of management of the clinically N0 neck (cN0) for tumors with significant (≥20%) incidence of occult regional metastasis. As a consequence, the majority of patients without regional metastasis will undergo unnecessary treatment. The purpose of this review was to discuss new developments in techniques that potentially improve the accuracy of the assessment of the neck in patients with HNSCC. Although imaging has improved in the last decades, a limitation common to all imaging techniques is a lack of sensitivity for small tumor deposits. Therefore, complementary to improvements in imaging techniques, developments in more invasive diagnostic procedures, such as sentinel node biopsy (SNB) will add to the accuracy of diagnostic algorithms for the staging of the neck., (© 2014 Wiley Periodicals, Inc.)
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- 2015
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35. Current philosophy in the surgical management of neck metastases for head and neck squamous cell carcinoma.
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Coskun HH, Medina JE, Robbins KT, Silver CE, Strojan P, Teymoortash A, Pellitteri PK, Rodrigo JP, Stoeckli SJ, Shaha AR, Suárez C, Hartl DM, de Bree R, Takes RP, Hamoir M, Pitman KT, Rinaldo A, and Ferlito A
- Subjects
- Carcinoma, Squamous Cell mortality, Disease-Free Survival, Evidence-Based Medicine, Female, Head and Neck Neoplasms mortality, Head and Neck Neoplasms pathology, Humans, Lymph Node Excision methods, Lymph Nodes pathology, Lymphatic Metastasis, Male, Neck Dissection mortality, Prognosis, Risk Assessment, Survival Analysis, Treatment Outcome, Carcinoma, Squamous Cell secondary, Carcinoma, Squamous Cell surgery, Head and Neck Neoplasms surgery, Lymph Nodes surgery, Neck Dissection methods
- Abstract
Neck dissection is an important treatment for metastases from upper aerodigestive carcinoma; an event that markedly reduces survival. Since its inception, the philosophy of the procedure has undergone significant change from one of radicalism to the current conservative approach. Furthermore, nonsurgical modalities have been introduced, and, in many situations, have supplanted neck surgery. The refinements of imaging the neck based on the concept of neck level involvement has encouraged new philosophies to evolve that seem to benefit patient outcomes particularly as this relates to diminished morbidity. The purpose of this review was to highlight the new paradigms for surgical removal of neck metastases using an evidence-based approach., (© 2014 Wiley Periodicals, Inc.)
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- 2015
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36. Sentinel node biopsy for early-stage oral cavity cancer: the VU University Medical Center experience.
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Den Toom IJ, Heuveling DA, Flach GB, van Weert S, Karagozoglu KH, van Schie A, Bloemena E, Leemans CR, and de Bree R
- Subjects
- Carcinoma, Squamous Cell therapy, Chemoradiotherapy, Head and Neck Neoplasms therapy, Humans, Lymphatic Metastasis, Lymphoscintigraphy, Mouth Neoplasms diagnostic imaging, Mouth Neoplasms mortality, Mouth Neoplasms therapy, Netherlands, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Survival Analysis, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms pathology, Mouth Neoplasms pathology, Sentinel Lymph Node Biopsy
- Abstract
Background: Sentinel node biopsy (SNB) in head and neck cancer is recently introduced as the staging technique of oral squamous cell carcinoma. We report the results of SNB in patients diagnosed with a T1-T2 oral squamous cell carcinoma and clinically negative (N0) neck in a single center., Methods: A retrospective analysis of 90 previously untreated patients who underwent SNB between 2007 and 2012 was performed. The SNB procedure consisted of preoperatively performed lymphoscintigraphy, intraoperative detection using blue dye, and gamma probe guidance and histopathologic examination including step-serial sectioning (SSS) and immunohistochemical (IHC) staining. A positive SNB was followed by neck dissection, whereas regular follow-up with ultrasound-guided fine-needle aspiration cytology (FNAC) was done in case of a negative SNB., Results: The lymphoscintigraphic identification rate was 98% (88 of 90 patients) and the surgical detection rate was 99% (87 of 88 patients). The upstaging rate was 30%. Sensitivity of SNB was 93% and the negative predictive value was 97%. The median follow-up was 18 months (range, 2-62 months). Overall survival (OS) and disease-free survival (DFS) for SNB negative were 100% and 84% and for SNB positive patients 73% and 88%, respectively., Conclusion: SNB is a reliable diagnostic staging technique for the clinically negative neck in patients with early-stage (T1-T2, cN0) oral squamous cell carcinoma., (© 2014 Wiley Periodicals, Inc.)
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- 2015
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37. Recurrent and second primary squamous cell carcinoma of the head and neck: when and how to reirradiate.
- Author
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Strojan P, Corry J, Eisbruch A, Vermorken JB, Mendenhall WM, Lee AW, Haigentz M Jr, Beitler JJ, de Bree R, Takes RP, Paleri V, Kelly CG, Genden EM, Bradford CR, Harrison LB, Rinaldo A, and Ferlito A
- Subjects
- Humans, Patient Selection, Radiotherapy Dosage, Radiotherapy, Computer-Assisted, Retreatment, Salvage Therapy, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell radiotherapy, Head and Neck Neoplasms radiotherapy, Neoplasm Recurrence, Local radiotherapy, Neoplasms, Second Primary radiotherapy
- Abstract
Background: Local and/or regional recurrence and metachronous primary tumor arising in a previously irradiated area are rather frequent events in patients with head and neck squamous cell carcinoma (HNSCC). Re-treatment is associated with an increased risk of serious toxicity and impaired quality of life (QOL) with an uncertain survival advantage., Methods: We analyzed the literature on the efficacy and toxicity of photon/electron-based external beam reirradiation for previously irradiated patients with HNSCC of non-nasopharyngeal origin. Studies were grouped according to the radiotherapy technique used for reirradiation. Patient selection criteria, target volume identification method, tumor dose, fractionation schedule, systemic therapy administration, and toxicities were reviewed., Results: In addition to disease-related factors, current comorbidities and preexisting organ dysfunction must be considered when selecting patients for reirradiation. As morbidity from re-treatment may be considerable and differ depending on which mode of re-treatment is used, it is important to give patients information on potential morbidity outcomes so that an informed choice can be made within a shared decision-making context. With improved dose distribution and adequate imaging support, including positron emission tomography-CT, modern radiotherapy techniques may improve local control and reduce toxicity of reirradiation. A reirradiation dose of ≥60 Gy and a volume encompassing the gross tumor with up to a 5-mm margin are recommended. Concomitant administration of systemic therapeutics and reirradiation is likely to be of similar benefit as observed in large randomized studies of upfront therapy., Conclusion: Reirradiation, administered either with or without concurrent systemic therapy, is feasible and tolerable in properly selected patients with recurrent or a new primary tumor in a previously irradiated area of the head and neck, offering a meaningful survival (in the range of 10% to 30% at 2 years). Whenever feasible, salvage surgery is the method of choice for curative intent; patients at high-risk for local recurrence should be advised that postoperative reirradiation is expected to increase locoregional control at the expense of higher toxicity and without survival advantage compared to salvage surgery without reirradiation. © 2014 Wiley Periodicals, Inc. Head Neck 37: 134-150, 2015., (© 2014 Wiley Periodicals, Inc.)
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- 2015
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38. Desmoid tumors of the head and neck: a therapeutic challenge.
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de Bree E, Zoras O, Hunt JL, Takes RP, Suárez C, Mendenhall WM, Hinni ML, Rodrigo JP, Shaha AR, Rinaldo A, Ferlito A, and de Bree R
- Subjects
- Diagnosis, Differential, Fibromatosis, Aggressive diagnosis, Fibromatosis, Aggressive etiology, Fibromatosis, Aggressive genetics, Fibromatosis, Aggressive radiotherapy, Fibromatosis, Aggressive surgery, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms etiology, Head and Neck Neoplasms genetics, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms surgery, Humans, Magnetic Resonance Imaging, Radiotherapy, Adjuvant, Tomography, X-Ray Computed, Treatment Outcome, Watchful Waiting, Fibromatosis, Aggressive therapy, Head and Neck Neoplasms therapy
- Abstract
Desmoid tumor, or aggressive fibromatosis, is a rare, histologically benign, fibroblastic lesion that infrequently presents in the head and neck. Desmoid tumors often grow locally, invasively, and may, in rare instances, be fatal secondary to invasion into critical structures, such as airway or major vessels. The most common treatment is surgery, but desmoid tumors are characteristically associated with a high local recurrence rate after resection. Although the margin status seems to be of importance, operations that avoid function loss and esthetic disfigurement should be the primary goal. The efficacy of postoperative radiotherapy is controversial. Its potential benefit should be carefully balanced against possible radiation-induced adverse effects. Alternative treatment modalities, such as primary radiotherapy and medical treatment or a wait-and-see policy, may be preferable to mutilating surgery. Considering all the aforementioned, it seems obvious that desmoid tumors of the head and neck present a therapeutic challenge and require an individualized approach., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2014
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39. Contemporary management of lymph node metastases from an unknown primary to the neck: II. a review of therapeutic options.
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Strojan P, Ferlito A, Langendijk JA, Corry J, Woolgar JA, Rinaldo A, Silver CE, Paleri V, Fagan JJ, Pellitteri PK, Haigentz M Jr, Suárez C, Robbins KT, Rodrigo JP, Olsen KD, Hinni ML, Werner JA, Mondin V, Kowalski LP, Devaney KO, de Bree R, Takes RP, Wolf GT, Shaha AR, Genden EM, and Barnes L
- Subjects
- Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Squamous Cell mortality, Chemoradiotherapy methods, Disease-Free Survival, Female, Head and Neck Neoplasms mortality, Humans, Lymph Nodes pathology, Male, Middle Aged, Neck Dissection methods, Neoplasms, Unknown Primary mortality, Neoplasms, Unknown Primary pathology, Prognosis, Randomized Controlled Trials as Topic, Risk Assessment, Survival Analysis, Treatment Outcome, Carcinoma, Squamous Cell secondary, Carcinoma, Squamous Cell therapy, Head and Neck Neoplasms secondary, Head and Neck Neoplasms therapy, Neoplasms, Unknown Primary therapy
- Abstract
Although uncommon, cancer of an unknown primary (CUP) metastatic to cervical lymph nodes poses a range of dilemmas relating to optimal treatment. The ideal resolution would be a properly designed prospective randomized trial, but it is unlikely that this will ever be conducted in this group of patients. Accordingly, knowledge gained from retrospective studies and experience from treating patients with known head and neck primary tumors form the basis of therapeutic strategies in CUP. This review provides a critical appraisal of various treatment approaches described in the literature. Emerging treatment options for CUP with metastases to cervical lymph nodes are discussed in view of recent innovations in the field of head and neck oncology and suitable therapeutic strategies for particular clinical scenarios are presented. For pN1 or cN1 disease without extracapsular extension (ECE), selective neck dissection or radiotherapy offer high rates of regional control. For more advanced neck disease, intensive combined treatment is required, either a combination of neck dissection and radiotherapy, or initial (chemo)radiotherapy followed by neck dissection if a complete response is not recorded on imaging. Each of these approaches seems to be equally effective. Use of extensive bilateral neck/mucosal irradiation must be weighed against toxicity, availability of close follow-up with elective neck imaging and guided fine-needle aspiration biopsy (FNAB) when appropriate, the human papillomavirus (HPV) status of the tumor, and particularly against the distribution pattern (oropharynx in the majority of cases) and the emergence rate of hidden primary lesions (<10% after comprehensive workup). The addition of systemic agents is expected to yield similar improvement in outcome as has been observed for known head and neck primary tumors., (Copyright © 2011 Wiley Periodicals, Inc.)
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- 2013
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40. Contemporary management of lymph node metastases from an unknown primary to the neck: I. A review of diagnostic approaches.
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Strojan P, Ferlito A, Medina JE, Woolgar JA, Rinaldo A, Robbins KT, Fagan JJ, Mendenhall WM, Paleri V, Silver CE, Olsen KD, Corry J, Suárez C, Rodrigo JP, Langendijk JA, Devaney KO, Kowalski LP, Hartl DM, Haigentz M Jr, Werner JA, Pellitteri PK, de Bree R, Wolf GT, Takes RP, Genden EM, Hinni ML, Mondin V, Shaha AR, and Barnes L
- Subjects
- Head and Neck Neoplasms pathology, Head and Neck Neoplasms secondary, Humans, Lymphatic Metastasis pathology, Neoplasms, Unknown Primary pathology, Head and Neck Neoplasms diagnosis, Lymph Nodes pathology, Lymphatic Metastasis diagnosis, Neoplasms, Unknown Primary diagnosis
- Abstract
In an era of advanced diagnostics, metastasis to cervical lymph nodes from an occult primary tumor is a rare clinical entity and accounts for approximately 3% of head and neck malignancies. Histologically, two thirds of cases are squamous cell carcinomas (SCCs), with other tissue types less common in the neck. With modern imaging and tissue examinations, a primary tumor initially undetected on physical examination is revealed in >50% of patients and the site of the index primary can be predicted with a high level of probability. In the present review, the range and limitations of diagnostic procedures are summarized and the optimal diagnostic workup is proposed. Initial preferred diagnostic procedures are a fine-needle aspiration biopsy (FNAB) and imaging. This allows directed surgical biopsy (such as tonsillectomy), based on the preliminary findings, and prevents misinterpretation of postsurgical images. When no primary lesion is suggested after imaging and panendoscopy, and for patients without a history of smoking and alcohol abuse, molecular profiling of an FNAB sample for human papillomavirus (HPV) and/or Epstein-Barr virus (EBV) is important., (Copyright © 2011 Wiley Periodicals, Inc.)
- Published
- 2013
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41. Implications of a positive sentinel node in oral squamous cell carcinoma.
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Gurney BA, Schilling C, Putcha V, Alkureishi LW, Alvarez AJ, Bakholdt V, Barbier Herrero L, Barzan L, Bilde A, Bloemena E, Salces CC, Dalla Palma P, de Bree R, Dequanter D, Dolivet G, Donner D, Flach GB, Fresno M, Grandi C, Haerle S, Huber GF, Hunter K, Lawson G, Leroux A, Lothaire PH, Mamelle G, Silini EM, Mastronicola R, Odell EW, O'Doherty MJ, Poli T, Rahimi S, Ross GL, Zuazua JS, Santini S, Sebbesen L, Shoaib T, Sloan P, Sorensen JA, Soutar DS, Therkildsen MH, Vigili MG, Villarreal PM, von Buchwald C, Werner JA, Wiegand S, and McGurk M
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- Carcinoma, Squamous Cell surgery, Female, Head and Neck Neoplasms surgery, Humans, Lymph Nodes surgery, Male, Middle Aged, Mouth Neoplasms surgery, Neck Dissection, Prognosis, Squamous Cell Carcinoma of Head and Neck, Survival Analysis, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms pathology, Lymph Nodes pathology, Lymphatic Metastasis pathology, Mouth Neoplasms pathology, Sentinel Lymph Node Biopsy methods
- Abstract
Background: The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome., Methods: In all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan-Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck., Results: A total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome., Conclusions: The results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans., (Copyright © 2012 Wiley Periodicals, Inc.)
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- 2012
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42. Sternocleidomastoid muscle flap in preventing Frey's syndrome after parotidectomy: a systematic review.
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Sanabria A, Kowalski LP, Bradley PJ, Hartl DM, Bradford CR, de Bree R, Rinaldo A, and Ferlito A
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- Controlled Clinical Trials as Topic, Female, Follow-Up Studies, Humans, Male, Muscle, Skeletal surgery, Parotid Gland physiopathology, Postoperative Complications prevention & control, Primary Prevention methods, Randomized Controlled Trials as Topic, Risk Assessment, Surgical Procedures, Operative methods, Sweating, Gustatory etiology, Treatment Outcome, Muscle, Skeletal transplantation, Parotid Gland surgery, Surgical Flaps blood supply, Surgical Procedures, Operative adverse effects, Sweating, Gustatory prevention & control
- Abstract
Background: Parotidectomy is a common procedure and Frey's syndrome (gustatory sweating) is a common side effect. The current literature was assessed concerning the effectiveness of the sternocleidomastoid muscle (SCM) flap to prevent Frey's syndrome after parotidectomy., Methods: A bibliography search was conducted for studies published between 1966 and 2010 and included randomized controlled trials (RCTs) or cohort studies with patients undergoing parotidectomy with facial nerve preservation. The outcome measures of particular interest were the incidence of Frey's syndrome and cosmetic impairment., Results: In all, 12 studies were selected (1 meta-analysis of all interventions to prevent Frey's syndrome, 2 RCTs, and 9 cohort studies). The trials were too heterogeneous to perform a meta-analysis on the effect of the SCM flap. The results reported by the authors of each study suggest an objective decrease in Frey's syndrome when the SCM flap was used, but there was no difference in the patients' subjective reporting of symptoms. However, this conclusion is prone to the biases inherent in these studies, and thus overall it is impossible to make any recommendation., Conclusion: Current reported evidence is inconclusive as to the use of SCM muscle flap as an intervention to prevent Frey's syndrome following parotid surgery., (Copyright © 2011 Wiley Periodicals, Inc.)
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- 2012
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43. Retropharyngeal lymph node metastases in head and neck malignancies.
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Coskun HH, Ferlito A, Medina JE, Robbins KT, Rodrigo JP, Strojan P, Suárez C, Takes RP, Woolgar JA, Shaha AR, de Bree R, Rinaldo A, and Silver CE
- Subjects
- Diagnostic Imaging, Humans, Incidence, Lymph Node Excision, Lymph Nodes pathology, Lymph Nodes surgery, Lymphatic Metastasis radiotherapy, Pharynx, Head and Neck Neoplasms pathology, Lymphatic Metastasis diagnosis
- Abstract
Retropharyngeal lymph node (RPLN) metastasis of primary head and neck cancer often receives less consideration than lymph node metastasis in the neck. With improvements in imaging techniques and reports of surgical pathology, there is an improved understanding of the risk and subsequently the need for treatment of RPLNs. The rates of RPLN metastasis from carcinomas of the nasopharynx, oropharynx, hypopharynx, postcricoid region, maxillary sinus, and cervical esophagus are sufficiently high to warrant routine treatment, either electively or therapeutically, of this region. Through improved diagnostic techniques and heightened awareness of RPLN metastasis, patients at risk of having these metastases can be treated more effectively., (Copyright © 2010 Wiley Periodicals, Inc.)
- Published
- 2011
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44. Contemporary management of sinonasal cancer.
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Robbins KT, Ferlito A, Silver CE, Takes RP, Strojan P, Snyderman CH, de Bree R, Haigentz M Jr, Langendijk JA, Rinaldo A, Shaha AR, Hanna EY, Werner JA, and Suárez C
- Subjects
- Antibodies, Monoclonal therapeutic use, Antineoplastic Agents therapeutic use, Combined Modality Therapy, Endoscopy, ErbB Receptors antagonists & inhibitors, Humans, Lymph Nodes radiation effects, Lymphatic Metastasis, Nasal Cavity, Protein Kinase Inhibitors therapeutic use, Quality of Life, Receptors, Vascular Endothelial Growth Factor antagonists & inhibitors, Nose Neoplasms therapy, Paranasal Sinus Neoplasms therapy
- Abstract
Background: Sinonasal cancer is a relatively uncommon entity encountered by head and neck oncologists, rhinologists, and skull base surgeons. Recent innovations in surgical and nonsurgical therapeutic modalities raise the question of whether there has been any measurable improvement for treatment outcomes., Methods: A retrospective review of data from recent studies that focus on surgery, radiation, and chemotherapy, or combinations thereof, was conducted., Results: Surgery continues to be the preferred treatment and provides the best results, albeit with an inherent bias based on patient selection. For advanced disease (T4 lesions), the survival rate remains only modest. Complications of treatment, including both surgical and radiation therapy, have been reduced., Conclusions: There is a need to improve the efficacy of treatment for this disease. Recommendations for the future direction of therapeutic investigations are outlined., (Copyright © 2010 Wiley Periodicals, Inc.)
- Published
- 2011
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45. Paratracheal lymph node dissection in cancer of the larynx, hypopharynx, and cervical esophagus: the need for guidelines.
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de Bree R, Leemans CR, Silver CE, Robbins KT, Rodrigo JP, Rinaldo A, Takes RP, Shaha AR, Medina JE, Suárez C, and Ferlito A
- Subjects
- Biopsy, Needle, Diagnostic Imaging standards, Esophageal Neoplasms surgery, Female, Humans, Hypopharyngeal Neoplasms surgery, Laryngeal Neoplasms surgery, Lymph Node Excision methods, Lymph Nodes surgery, Magnetic Resonance Imaging standards, Male, Needs Assessment, Neoplasm Staging, Positron-Emission Tomography standards, Prognosis, Tomography, X-Ray Computed standards, Trachea pathology, Esophageal Neoplasms diagnosis, Hypopharyngeal Neoplasms diagnosis, Laryngeal Neoplasms diagnosis, Lymph Node Excision standards, Lymph Nodes pathology, Practice Guidelines as Topic
- Abstract
In laryngeal, hypopharyngeal, and cervical esophageal carcinomas, the paratracheal lymph nodes (PTLN) may be at risk for lymph node metastasis. The presence of PTLN metastasis is an important prognostic factor for the development of mediastinal and distant metastases, stomal recurrence, and disease-free and overall survival. Studies on PTLN metastasis are scarce. In most studies, PTLN dissection has not been routinely performed, and selection criteria for PTLN dissection are usually not well defined. Therefore, in most reported studies, selection bias is present and results are difficult to compare. The reported prevalence of PTLN metastases varies according to the site and stage of the primary tumor: subglottic cancer, transglottic cancer, and glottic cancer with subglottic extension have a higher risk of PTLN metastases. Diagnostic imaging is not sufficiently reliable to detect occult PTLN metastases and avoid unnecessary PTLN dissections. PTLN dissection is associated with limited morbidity, but damage to major vessels may occur, and because of exposure of these vessels PTLN may increase the morbidity of fistulae that can occur after total laryngectomy. The dissection may produce hypocalcemia, if performed bilaterally. Nevertheless, the limited morbidity and high rate of metastasis in specific laryngeal, hypopharyngeal, and cervical esophageal carcinomas argue in favor of routine elective PTLN treatment for these tumors. Large prospective studies are needed to identify the patients at risk with primary tumors in more detail. Moreover, improved diagnostic imaging is needed to detect (occult) PTLN metastases more reliably. Based on future studies, clinical guidelines have to be developed to avoid undertreatment and overtreatment., (Copyright © 2010 Wiley Periodicals, Inc.)
- Published
- 2011
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46. Central compartment dissection in laryngeal cancer.
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Medina JE, Ferlito A, Robbins KT, Silver CE, Rodrigo JP, de Bree R, Rinaldo A, Elsheikh MN, Weber RS, and Werner JA
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- Humans, Lymph Nodes anatomy & histology, Lymphatic Metastasis, Lymphatic System anatomy & histology, Prognosis, Laryngeal Neoplasms pathology, Neck Dissection methods
- Abstract
We report here a review of the literature intended to clarify the nomenclature and boundaries of the nodes in the "central compartment" of the neck, the frequency with which tumors from the different laryngeal sites metastasize to these nodes, and the indications for central compartment node dissection in the treatment of cancers of the larynx. From this review, we conclude that, until consensus is reached about grouping of the lymph nodes in this area, it is best to refer to these nodes by their anatomic location, ie, prelaryngeal, pretracheal, or paratracheal lymph nodes. It is also advisable to describe dissection of these nodes as selective neck dissection (SND) with an annotation about the specific lymph node groups removed. Metastases in prelaryngeal and paratracheal lymph nodes in patients with squamous cell carcinoma of the larynx are associated with increased tumor recurrence, more frequent metastases in lymph nodes of the lateral compartment of the neck, and decreased survival. If untreated, they may lead to the development of peristomal recurrence. Therefore, elective treatment of level VI nodes is recommended in patients with squamous cell carcinomas of the subglottic region, advanced glottis carcinomas with subglottic extension, and in certain advanced carcinomas of the supraglottic region., (Copyright © 2010 Wiley Periodicals, Inc.)
- Published
- 2011
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47. Proposal for a rational classification of neck dissections.
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Ferlito A, Robbins KT, Shah JP, Medina JE, Silver CE, Al-Tamimi S, Fagan JJ, Paleri V, Takes RP, Bradford CR, Devaney KO, Stoeckli SJ, Weber RS, Bradley PJ, Suárez C, Leemans CR, Coskun HH, Pitman KT, Shaha AR, de Bree R, Hartl DM, Haigentz M Jr, Rodrigo JP, Hamoir M, Khafif A, Langendijk JA, Owen RP, Sanabria A, Strojan P, Vander Poorten V, Werner JA, Bień S, Woolgar JA, Zbären P, Betka J, Folz BJ, Genden EM, Talmi YP, Strome M, González Botas JH, Olofsson J, Kowalski LP, Holmes JD, Hisa Y, and Rinaldo A
- Subjects
- Competitive Bidding, Female, Humans, International Cooperation, Male, Neck Dissection standards, Practice Guidelines as Topic, Terminology as Topic, Guideline Adherence, Head and Neck Neoplasms surgery, Neck Dissection classification
- Published
- 2011
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48. Effectiveness of salvage selective and modified radical neck dissection for regional pathologic lymphadenopathy after chemoradiation.
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van der Putten L, van den Broek GB, de Bree R, van den Brekel MW, Balm AJ, Hoebers FJ, Doornaert P, Leemans CR, and Rasch CR
- Subjects
- Biopsy, Fine-Needle, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell radiotherapy, Female, Head and Neck Neoplasms mortality, Head and Neck Neoplasms pathology, Humans, Lymph Nodes pathology, Lymphatic Metastasis, Male, Multivariate Analysis, Neoplasm Recurrence, Local, Neoplasm, Residual surgery, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Survival Analysis, Ultrasonography, Interventional, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms radiotherapy, Neck Dissection methods, Salvage Therapy
- Abstract
Background: The objective of this study was to evaluate the effectiveness and safety of our careful observational strategy and neck dissections and the accuracy of ultrasound-guided fine-needle aspiration cytology, and to determine the prognostic factors for outcome and regional control after primary chemoradiation. Diagnostic evaluation of the regional status after concurrent chemoradiation for advanced head and neck cancer remains difficult, and the indications for a salvage neck dissection and its extent are not clearly defined., Methods: In a series of 540 patients, there was suspicion of regional residual or recurrent disease after chemoradiation in 61 patients who underwent 68 salvage neck dissections and 68 patients who were considered unresectable. For the patients with salvage neck dissection, the accuracy of ultrasound-guided fine-needle aspiration cytology was determined. Disease control in the neck, disease-specific and overall survival, and parameters that may have prognostic value for the outcome were evaluated., Results: Neck dissection specimens contained viable tumor in 26 (43%) patients. Of these, 13 had selective neck dissections and 13 modified radical neck dissections. Ultrasound-guided fine-needle aspiration cytology had a sensitivity of 80% and specificity of 42%. Nine patients developed a regional recurrence after salvage neck dissection (5 located in contralateral neck). Five-year regional control and overall survival rates were 79% and 36%, respectively. Significant prognostic factors for overall survival were surgical margins and "residual versus recurrent disease" in multivariate analysis., Conclusion: Considering the good regional control rate and the high rate of unnecessary neck dissections with a theoretical planned neck dissection strategy, we conclude that a careful observational strategy is worthwhile and safe. For the evaluation of radiation treatment response, ultrasound-guided fine-needle aspiration cytology has a low specificity.
- Published
- 2009
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49. Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy.
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Meleti M, Leemans CR, de Bree R, Vescovi P, Sesenna E, and van der Waal I
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- Adult, Aged, Aged, 80 and over, Female, Head and Neck Neoplasms pathology, Head and Neck Neoplasms surgery, Humans, Italy, Male, Medical Records, Melanoma pathology, Melanoma surgery, Middle Aged, Mucous Membrane pathology, Neoplasm Recurrence, Local, Neoplasm Staging, Netherlands, Postoperative Period, Prognosis, Radiotherapy, Adjuvant, Retrospective Studies, Survival Analysis, Treatment Outcome, Head and Neck Neoplasms radiotherapy, Melanoma radiotherapy, Mucous Membrane radiation effects
- Abstract
Background: Treatment of head and neck mucosal melanoma remains a challenge. Surgery has traditionally been the main therapeutic approach. The role of postoperative radiotherapy has never been clearly established., Methods: The experience with a group of 42 patients (16 males, 26 females) with a primary head and neck mucosal melanoma is reported., Results: Eleven of 19 patients (57.9%) receiving surgery alone developed a regional lymphatic metastasis. For patients receiving postoperative radiotherapy (19 patients), regional metastatic spread occurred in 4 patients (21%). Percentages of local failure were 57.9% (11/19) and 26.3% (5/19) for patients treated with surgery alone and for those treated with surgery and radiotherapy, respectively. Distant metastases occurred in 10 of 19 patients (52.6%) receiving surgery alone and in 9 of 19 patients (47.3%) receiving both therapies., Conclusions: The present evaluation confirms a poor prognosis for patients with head and neck mucosal melanoma, independent of the treatment modality., ((c) 2008 Wiley Periodicals, Inc.)
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- 2008
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50. Systematic review: accuracy of imaging tests in the diagnosis of recurrent laryngeal carcinoma after radiotherapy.
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Brouwer J, Hooft L, Hoekstra OS, Riphagen II, Castelijns JA, de Bree R, and Leemans CR
- Subjects
- Carcinoma, Squamous Cell therapy, Confidence Intervals, Female, Humans, Laryngeal Neoplasms therapy, Magnetic Resonance Imaging methods, Male, Observer Variation, Positron-Emission Tomography methods, Probability, ROC Curve, Risk Assessment, Sensitivity and Specificity, Tomography, X-Ray Computed methods, Carcinoma, Squamous Cell diagnosis, Diagnostic Imaging methods, Fluorodeoxyglucose F18, Laryngeal Neoplasms diagnosis, Neoplasm Recurrence, Local diagnosis, Neoplasm Recurrence, Local radiotherapy
- Abstract
Background: Diagnosing recurrent laryngeal tumor after radiotherapy is challenging. The most reliable method is direct laryngoscopy under general anesthesia. However, many futile laryngoscopies are performed in disease-free patients. Imaging tests selecting patients for this invasive procedure would be useful. The aim of this systematic review was summarizing the available evidence and determining the diagnostic accuracy of CT, MRI, thallium-201 (201Tl) scintigraphy, and F-18-fluorodeoxyglucose positron emission tomography (18FDG-PET)., Methods: A systematic review was performed according to the guidelines of the Cochrane Collaboration. Two reviewers scored the articles according to A-, B-, and C-items. Statistical meta-analysis was performed producing summary pooled estimates of sensitivity and specificity., Results: There were 8 eligible studies on 18FDG-PET. The validity of the 18FDG-PET studies was reasonable; the pooled estimates (95% CI) for sensitivity and specificity were 89% and 74%., Conclusion: The diagnostic accuracy of 18FDG-PET is promising and warrants a randomized trial comparing a strategy based on conventional diagnostic work-up to one based on 18FDG-PET.
- Published
- 2008
- Full Text
- View/download PDF
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