1. Adjuvant Vitamin D Injection in Elderly Patients Before Intertrochanteric Fracture Surgery: A Randomised Controlled Trial.
- Author
-
Rabiee Rad, Mehrdad, Ghasempour Dabaghi, Ghazal, Afshari Safavi, Alireza, Moshkdar, Pooya, and Akbariaghdam, Hossein
- Subjects
MORTALITY ,POSTOPERATIVE care ,REPEATED measures design ,RISK assessment ,HIP fractures ,PLACEBOS ,PHYSIOLOGIC salines ,COMPUTER software ,DATA analysis ,T-test (Statistics) ,DEATH ,INTRAMUSCULAR injections ,BLIND experiment ,QUESTIONNAIRES ,STATISTICAL sampling ,PRIVACY ,FISHER exact test ,TREATMENT effectiveness ,RANDOMIZED controlled trials ,PREOPERATIVE care ,AGE distribution ,DESCRIPTIVE statistics ,CHI-squared test ,MANN Whitney U Test ,SURGICAL complications ,KAPLAN-Meier estimator ,LOG-rank test ,TELEPHONES ,INTENTION ,STATISTICS ,ANALYSIS of variance ,DATA analysis software ,SURVIVAL analysis (Biometry) ,CONFIDENCE intervals ,VITAMIN D ,PROPORTIONAL hazards models ,REGRESSION analysis ,MEDICAL ethics ,EVALUATION ,OLD age - Abstract
Background: There are multiple recommended protocols for Vitamin D (VitD) supplementation in elderly; however, only a few studies achieved to examine the role of VitD supplements before intertrochanteric fracture surgery on mortality and complications after surgery. Methods: This single-center block-randomized double-blinded trial was conducted on 80 patients with intertrochanteric fractures and a sufficient level of 25 (OH) VitD. The intervention group received an intramuscular 300,000 IU VitD ampule before surgery. The primary outcome was a 6-month mortality rate, and the secondary outcomes were 1- and 2-year mortality rates and Harris Hip Score (HHS) in 6, 12, and 24 months after surgery. Chi-square, t-test, repeated measure ANOVA, and Cox regression survival model was used for statistical analysis. Results: 40 patients were allocated to each group. Demographic, clinical characteristics, and preoperative evaluations were not significantly different between the groups. Mortality rate 6-month after the surgery was 7.5% and 10% for the intervention and placebo groups respectively (P value =.71), 15% and 12.5% at 1-year (P value =.83), and 25% and 27.5% at 2-year (P value =.98). Based on the Cox regression model, only age was significantly associated with mortality (HR = 1.229, P value <.001). Significant HHS changes from baseline through 24 months after surgery were observed within both groups; however, mean differences were not significantly different between groups. Conclusions: A single preoperative 300,000 IU VitD did not significantly impact 2-year survival and HHS in patients with intertrochanteric fractures and sufficient serum VitD level. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF