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Your search keyword '"Shutter, John R."' showing total 4 results
Start Over Author "Shutter, John R." Journal genes & development
4 results on '"Shutter, John R."'

1. Dosage-sensitive requirement for mouse D114 in artery development

Author

Duarte, Antonio, Bekman, Evguenia, Shutter, John R., Costa, Luis, Benedito, Rui, Henrique, Domingos, Trindade, Alexandre, Rossant, Janet, Diniz, Patricia, and Hirashima, Masanori

Subjects
Autocrine mechanisms -- Research, Molecular biology -- Research, Ligands (Biochemistry) -- Research, Gene mutations -- Research, Biological sciences
Abstract

Involvement of the Notch pathway in vascular devolvement is demonstrated by both gain -and loss-of-function mutations in humans, mice, and zebrafish. The Delta-like 4 (D114) ligand alone is required in a dossage-sensitive manner for normal arterial patterning in development, which implicates D114 as the specific mammalian endothelial for autocrine endothelial Notch signaling.

Published
2004

2. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

Author

Krebs, Luke T., Gridley, Thomas, Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, and Stark, Kevin L.

Subjects
Lethal mutation -- Research, Arteriovenous malformations -- Research, Biological sciences
Abstract

The mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand exhibit happloinsufficient lethality because of defects in vascular remodeling is reported. Notch pathway mutant embryos exhibit defects in arterial specification of nascent blood vessels and develop arteriovenous malformations.

Published
2004

3. Notch signaling is essential for vascular morphogenesis in mice

Author

Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., Gallahan, Daniel, Closson, Violaine, Kitajewski, Jan, Callahan, Robert, Smith, Gilbert H., Stark, Kevin L., and Gridley, Thomas

Subjects
Heredity -- Research, Morphogenesis -- Analysis, Gene expression -- Research, Ligands -- Research, Biological sciences
Abstract

Research has been conducted on the role of the Notch4 gene in the intercellular signaling mechanism. The generation of the Notch4-deficient mice by gene targeting is described.

Published
2000

4. D114, a novel Notch ligand expressed in arterial endothelium

Author

Shutter, John R., Scully, Sheila, Fan, Wei, Richards, William G., Kitajewski, Jan, Deblandre, Gisele A., Kintner, Chris R., and Stark, Kevin L.

Subjects
Heredity -- Research, Ligands -- Research, Endothelium -- Analysis, Gene expression -- Research, Cloning -- Research, Biological sciences
Abstract

Research has been conducted on D114 gene of the Notch ligands. The results of the cloning and characterization of this gene are presented.

Published
2000

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