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Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
- Source :
- Genes & Development. Oct 15, 2004, Vol. 18 Issue 20, p2469, 5 p.
- Publication Year :
- 2004
-
Abstract
- The mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand exhibit happloinsufficient lethality because of defects in vascular remodeling is reported. Notch pathway mutant embryos exhibit defects in arterial specification of nascent blood vessels and develop arteriovenous malformations.
Details
- Language :
- English
- ISSN :
- 08909369
- Volume :
- 18
- Issue :
- 20
- Database :
- Gale General OneFile
- Journal :
- Genes & Development
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.125474807