1. Sinensiols B-G, six novel neolignans from Selaginella sinensis.
- Author
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Chen, Xi, Xu, Ping-Sheng, Zou, Zhen-Xing, Liu, Yang, Zhou, Wen-Hao, Ren, Qin, Li, Dan, Li, Xiao-Min, Xu, Kang-Ping, and Tan, Gui-Shan
- Subjects
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CELL lines , *CELL surface antigens , *CELLULAR signal transduction , *HIGH performance liquid chromatography , *IMMUNODIAGNOSIS , *LIGNANS , *LIQUID chromatography , *MASS spectrometry , *MEDICINAL plants , *GENETIC mutation , *NUCLEAR magnetic resonance spectroscopy , *PLANTS , *PLANT extracts - Abstract
Six new neolignans, sinensiols B-G (1–6), together with three known analogues (7–9) were isolated from the whole plant of Selaginella sinensis. Their planar structures were established by comprehensive spectroscopic analyses including 1D, 2D NMR, IR and HRESIMS data. The absolute configurations of new compounds were elucidated by comparing their experimental CD spectra with known ones and using the reversed helicity rule for the 1L b band ECD of dihydrobenzofuran neolignans. Sinensiols A-D (7 , 1–3) belong to sesquilignan with a dimer of dihydrobenzo[ b ]furan moiety. The potential precursors of sinensiols A, B, D were also reported in this paper. In addition, all new compounds were screened for their cytotoxicity against A549 and HepG2 human cancer cell lines, and they didn't show inhibition on the growth of cancer cells. Unlabelled Image [ABSTRACT FROM AUTHOR]
- Published
- 2019
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