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Determination of ligustilide in the brains of freely moving rats using microdialysis coupled with ultra performance liquid chromatography/mass spectrometry
- Source :
-
Fitoterapia . Apr2011, Vol. 82 Issue 3, p441-445. 5p. - Publication Year :
- 2011
-
Abstract
- Abstract: In this paper, microdialysis combined with ultra performance liquid chromatography/mass spectrometry (UPLC-MS) was applied for the determination of ligustilide in freely moving rats'' brain. The extracellular unbound ligustilide could be detected in rat brain within the first time interval (0–20min) after nasal administration but not after oral administration. This result showed that ligustilide could quickly enter the brain after nasal administration; which implied that ligustilide may have a rapid onset of action. This work demonstrated the potential application of microdialysis combined with UPLC-MS in pharmacokinetic studies. Furthermore, the advantage that fewer animals used in the microdialysis experiment was confirmed. [Copyright &y& Elsevier]
- Subjects :
- *MEDICINAL plants
*INTRANASAL medication
*ALTERNATIVE medicine
*ANALYSIS of variance
*ANIMAL experimentation
*BIOPHYSICS
*BRAIN
*DIALYSIS (Chemistry)
*LIQUID chromatography
*MASS spectrometry
*RESEARCH methodology
*ORAL drug administration
*RATS
*RESEARCH funding
*PHYTOCHEMICALS
*PLANT extracts
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 82
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 58095773
- Full Text :
- https://doi.org/10.1016/j.fitote.2010.12.002