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2 results on '"MALAT-1"'

1. MALAT-1 interacts with hnRNP C in cell cycle regulation.

Author

Yang, Feng, Yi, Fan, Han, Xiaorui, Du, Quan, and Liang, Zicai

Subjects
*LUNG cancer treatment, *CELL cycle regulation, *CHROMOSOMAL translocation, *CYTOPLASM, *GENE expression, *GENETIC regulation, *METASTASIS, *TRANSCRIPTION factors, *NUCLEOPROTEINS
Abstract

Highlights: [•] Translocation of MALAT-1 from the nucleus to the cytoplasm during G2/M cell cycle phase. [•] Down-regulation of MALAT-1 expression compromises the cytoplasmic translocation of hnRNP C and leads to cell cycle arrest. [•] MALAT-1 interacts with hnRNP C to function in cell cycle regulation. [ABSTRACT FROM AUTHOR]

Published
2013
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2. MALAT-1 interacts with hnRNP C in cell cycle regulation

Author

Quan Du, Zicai Liang, Xiaorui Han, Fan Yi, and Feng Yang

Subjects
G2 Phase, Cytoplasm, Biophysics, Down-Regulation, Chromosomal translocation, Biology, Cell cycle, Biochemistry, C protein, Structural Biology, Genetics, medicine, Humans, Gene Silencing, Molecular Biology, Gene, Cell Nucleus, Heterogeneous-Nuclear Ribonucleoprotein Group C, RNA, Biological Transport, Cell Biology, Hep G2 Cells, MALAT-1, Flow Cytometry, Molecular biology, Long non-coding RNA, Cell biology, medicine.anatomical_structure, RNA, Long Noncoding, Nucleus, Cell Division, hnRNP C, HeLa Cells
Abstract

As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that down-regulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation.

Published
2013

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