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MALAT-1 interacts with hnRNP C in cell cycle regulation
- Source :
- FEBS letters. 587(19)
- Publication Year :
- 2013
-
Abstract
- As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that down-regulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation.
- Subjects :
- G2 Phase
Cytoplasm
Biophysics
Down-Regulation
Chromosomal translocation
Biology
Cell cycle
Biochemistry
C protein
Structural Biology
Genetics
medicine
Humans
Gene Silencing
Molecular Biology
Gene
Cell Nucleus
Heterogeneous-Nuclear Ribonucleoprotein Group C
RNA
Biological Transport
Cell Biology
Hep G2 Cells
MALAT-1
Flow Cytometry
Molecular biology
Long non-coding RNA
Cell biology
medicine.anatomical_structure
RNA, Long Noncoding
Nucleus
Cell Division
hnRNP C
HeLa Cells
Subjects
Details
- ISSN :
- 18733468
- Volume :
- 587
- Issue :
- 19
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....1e7b0447bce3c4625f1158b1ce2e3fb5