1. Regulation of cell structure and function by actin-binding proteins: Villin’s perspective
- Author
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Khurana, Seema and George, Sudeep P.
- Subjects
- *
CELLULAR control mechanisms , *ACTIN , *CARRIER proteins , *EPITHELIAL cells - Abstract
Abstract: Villin is a tissue-specific actin modifying protein that is associated with actin filaments in the microvilli and terminal web of epithelial cells. It belongs to a large family of actin-binding proteins which includes actin-capping, -nucleating and/or -severing proteins such as gelsolin, severin, fragmin, adseverin/scinderin and actin crosslinking proteins such as dematin and supervillin. Studies done in epithelial cell lines and villin knock-out mice have demonstrated the function of villin in regulating actin dynamics, cell morphology, epithelial-to-mesenchymal transition, cell migration and cell survival. In addition, the ligand-binding properties of villin (F-actin, G-actin, calcium, phospholipids and phospholipase C-γ1) are mechanistically important for the crosstalk between signaling pathways and actin reorganization in epithelial cells. [Copyright &y& Elsevier]
- Published
- 2008
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