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Start Over Author "HU Tingting" Topic cellular signal transduction Journal febs letters

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1. Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways.

Author

Ji, Lingling, Xue, Ruyi, Tang, Wenqing, Wu, Weibin, Hu, Tingting, Liu, Xijun, Peng, Xiaomin, Gu, Jianxin, Chen, She, and Zhang, Si

Subjects
*TOLL-like receptors, *LIVER diseases, *FIBROSIS, *CARBON tetrachloride, *MITOGEN-activated protein kinases, *CELLULAR signal transduction, *NF-kappa B, *NEUROFIBROMATOSIS
Abstract

Highlights: [•] CCl4-induced elevation of serum ALP and TBIL was reduced in TLR2−/− mice. [•] CCl4-induced liver collagen deposition was attenuated in TLR2−/− mice. [•] CCl4-induced inflammatory response was ameliorated in TLR2−/− mice. [•] CCl4-induced activation of MAPK and NF-κB signaling pathways was attenuated in TLR2−/− mice. [Copyright &y& Elsevier]

Published
2014
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