Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways.

Highlights: [•] CCl4-induced elevation of serum ALP and TBIL was reduced in TLR2−/− mice. [•] CCl4-induced liver collagen deposition was attenuated in TLR2−/− mice. [•] CCl4-induced inflammatory response was ameliorated in TLR2−/− mice. [•] CCl4-induced activation of MAPK and NF-κB signaling pathways was attenuated in TLR2−/− mice. [Copyright &y& Elsevier]