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2. Changes in gentamicin pharmacokinetics after reduction of renal parenchyma

Author

Hatala M, Morávek J, and Schück O

Subjects
medicine.medical_specialty, Renal parenchyma, Urology, Nephron, Kidney, urologic and male genital diseases, Nephrectomy, Cellular and Molecular Neuroscience, Elimination rate constant, Pharmacokinetics, medicine, Animals, Molecular Biology, Pharmacology, urogenital system, Chemistry, Cell Biology, Rats, Surgery, medicine.anatomical_structure, Linear relation, Molecular Medicine, Female, Gentamicin, Gentamicins, medicine.drug
Abstract

The relationship between the elimination constant of gentamicin and the percentage of functioning nephrons in rats cannot be characterized by a simple linear relation. The results support the assumption that gentamicin elimination per residual nephron increased.

Published
1977
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