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Start Over Author "Wagner, Norbert" Journal european journal of immunology
6 results on '"Wagner, Norbert"'

6. Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes.

Author

Czarneski J, Berguer P, Bekinschtein P, Kim DC, Hakimpour P, Wagner N, Nepomnaschy I, Piazzon I, and Ross SR

Subjects
Animals, Animals, Newborn, Antigens, Viral immunology, B-Lymphocytes immunology, B-Lymphocytes virology, Cadherins physiology, Cell Adhesion, Cell Adhesion Molecules, Cell Movement, Cytokines physiology, Female, Immunoglobulins physiology, Integrins deficiency, Integrins genetics, Intestinal Mucosa immunology, Intestinal Mucosa pathology, Intestinal Mucosa virology, L-Selectin genetics, Lactation, Lymphocyte Cooperation, Lymphocyte Subsets cytology, Lymphocyte Subsets virology, Lymphoid Tissue immunology, Lymphoid Tissue pathology, Mammary Glands, Animal immunology, Mammary Glands, Animal pathology, Mice, Mice, Inbred C3H, Mice, Knockout, Milk virology, Mucins physiology, Mucoproteins physiology, Peyer's Patches immunology, Peyer's Patches virology, Superantigens immunology, T-Lymphocyte Subsets immunology, T-Lymphocyte Subsets virology, Integrin beta Chains, Integrins physiology, L-Selectin physiology, Lymphocyte Subsets immunology, Mammary Tumor Virus, Mouse physiology, Retroviridae Infections immunology, Tumor Virus Infections immunology
Abstract

Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.

Published
2002
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