Back to Search Start Over

Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes.

Authors :
Czarneski J
Berguer P
Bekinschtein P
Kim DC
Hakimpour P
Wagner N
Nepomnaschy I
Piazzon I
Ross SR
Source :
European journal of immunology [Eur J Immunol] 2002 Apr; Vol. 32 (4), pp. 945-56.
Publication Year :
2002

Abstract

Mouse mammary tumor virus (MMTV) is acquired by neonates through milk and first infects lymphocytes in Peyer's patches. We show here that newborn mice lacking beta7 integrin or L-selectin were infected with MMTV at wild-type levels in both their lymphoid and mammary tissues. Superantigen-mediated activation and cognate T cell deletion were also unimpaired in both types of null mice. A large proportion of neonatal Peyer's patch lymphocytes in wild-type mice were beta7 and beta1 integrin low and both populations increased in response to MMTV infection. These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection.

Details

Language :
English
ISSN :
0014-2980
Volume :
32
Issue :
4
Database :
MEDLINE
Journal :
European journal of immunology
Publication Type :
Academic Journal
Accession number :
11920560
Full Text :
https://doi.org/10.1002/1521-4141(200204)32:4<945::AID-IMMU945>3.0.CO;2-M