1. Could polymerase chain reaction tests on conjunctival swabs be useful to diagnose herpetic keratitis?
- Author
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Barrado L, Suarez MJ, Pérez-Blázquez E, Otero JR, and Folgueira MD
- Subjects
- Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Virology methods, Herpesvirus 1, Human, Keratitis, Herpetic diagnosis, Keratitis, Herpetic virology, Polymerase Chain Reaction
- Abstract
Introduction: Diagnosis of HSV-1 keratitis (HK) is frequently based on clinical findings. Invasive specimens (corneal scrapings, biopsies) are required for microbiological diagnosis., Methods: Corneal scrapings and conjunctival swabs were collected on patients with/without clinical suspicion of HK from 2007 to 2012., Results: The sensitivity, specificity, positive and negative predictive values for conjunctival swabs by PCR was 77.8, 92.1, 84.4 and 88.3, respectively., Discussion: Conjunctival swabs by PCR may help in the diagnosis of HK, despite the limited sensitivity., (Copyright © 2013 Elsevier España, S.L. All rights reserved.)
- Published
- 2014
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