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Staphylococcus aureus is a common cause of respiratory infections, including pneumonia (1), and can lead to necrotizing pneumonia and death (2-4). Influenza complicated by S. aureus co-infection can progress rapidly [...]

We performed antimicrobial drug susceptibility testing and molecular typing on invasive methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 1,666) submitted to the University of Iowa Hygienic Laboratory during 1999-2006 as [...]

The food supply, including poultry products, may transmit antimicrobial drug-resistant Escherichia coli to humans. To assess this hypothesis, 931 geographically and temporally matched E. coli isolates from human volunteers (hospital [...]

Provides information on a study that focused on the mechanisms of cefepime resistance among extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in Taiwan. Methodology of the study; Results and discussion on the study; Conclusions.

To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum beta-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented.