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Cefepime MIC as a predictor of the extended-spectrum beta-lactamase type in Klebsiella pneumoniae, Taiwan.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2002 May; Vol. 8 (5), pp. 522-4. - Publication Year :
- 2002
-
Abstract
- To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum beta-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented.
- Subjects :
- Cefepime
Humans
Klebsiella pneumoniae physiology
Microbial Sensitivity Tests
Phenotype
Taiwan epidemiology
beta-Lactamases genetics
Cephalosporins pharmacology
Drug Resistance, Multiple, Bacterial genetics
Klebsiella pneumoniae drug effects
Klebsiella pneumoniae enzymology
beta-Lactamases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6040
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 11996691
- Full Text :
- https://doi.org/10.3201/eid0805.010346