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Your search keyword '"Montagner, Alexandra"' showing total 4 results
Start Over Author "Montagner, Alexandra" Journal embo molecular medicine
4 results on '"Montagner, Alexandra"'

1. Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer

Author

Montagner, Alexandra, Delgado, Maria B, Tallichet-Blanc, Corinne, Chan, Jeremy S K, Sng, Ming K, Mottaz, Hélène, Degueurce, Gwendoline, Lippi, Yannick, Moret, Catherine, Baruchet, Michael, Antsiferova, Maria, Werner, Sabine, Hohl, Daniel, Al Saati, Talal, Farmer, Pierre J, Tan, Nguan S, Michalik, Liliane, and Wahli, Walter

Published
2014
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2. Identification of a novel PPAR β/δ/miR‐21‐3p axis in UV ‐induced skin inflammation

Author

Degueurce, Gwendoline, primary, D'Errico, Ilenia, additional, Pich, Christine, additional, Ibberson, Mark, additional, Schütz, Frédéric, additional, Montagner, Alexandra, additional, Sgandurra, Marie, additional, Mury, Lionel, additional, Jafari, Paris, additional, Boda, Akash, additional, Meunier, Julien, additional, Rezzonico, Roger, additional, Brembilla, Nicolò Costantino, additional, Hohl, Daniel, additional, Kolios, Antonios, additional, Hofbauer, Günther, additional, Xenarios, Ioannis, additional, and Michalik, Liliane, additional

Published
2016
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3. Src is activated by the nuclear receptor peroxisome proliferator‐activated receptor β/δ in ultraviolet radiation‐induced skin cancer

Author

Montagner, Alexandra, primary, Delgado, Maria B, additional, Tallichet‐Blanc, Corinne, additional, Chan, Jeremy S K, additional, Sng, Ming K, additional, Mottaz, Hélène, additional, Degueurce, Gwendoline, additional, Lippi, Yannick, additional, Moret, Catherine, additional, Baruchet, Michael, additional, Antsiferova, Maria, additional, Werner, Sabine, additional, Hohl, Daniel, additional, Al Saati, Talal, additional, Farmer, Pierre J, additional, Tan, Nguan S, additional, Michalik, Liliane, additional, and Wahli, Walter, additional

Published
2013
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4. Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation.

Author

Degueurce, Gwendoline, D'Errico, Ilenia, Pich, Christine, Ibberson, Mark, Schütz, Frédéric, Montagner, Alexandra, Sgandurra, Marie, Mury, Lionel, Jafari, Paris, Boda, Akash, Meunier, Julien, Rezzonico, Roger, Brembilla, Nicolò Costantino, Hohl, Daniel, Kolios, Antonios, Hofbauer, Günther, Xenarios, Ioannis, and Michalik, Liliane

Abstract

Although excessive exposure to UV is widely recognized as a major factor leading to skin perturbations and cancer, the complex mechanisms underlying inflammatory skin disorders resulting from UV exposure remain incompletely characterized. The nuclear hormone receptor PPARβ/δ is known to control mouse cutaneous repair and UV-induced skin cancer development. Here, we describe a novel PPARβ/δ-dependent molecular cascade involving TGFβ1 and miR-21-3p, which is activated in the epidermis in response to UV exposure. We establish that the passenger mi RNA miR-21-3p, that we identify as a novel UV-induced mi RNA in the epidermis, plays a pro-inflammatory function in keratinocytes and that its high level of expression in human skin is associated with psoriasis and squamous cell carcinomas. Finally, we provide evidence that inhibition of miR-21-3p reduces UV-induced cutaneous inflammation in ex vivo human skin biopsies, thereby underlining the clinical relevance of mi RNA-based topical therapies for cutaneous disorders. [ABSTRACT FROM AUTHOR]

Published
2016
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