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Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation.
- Source :
- EMBO Molecular Medicine; Aug2016, Vol. 8 Issue 8, p919-936, 18p
- Publication Year :
- 2016
-
Abstract
- Although excessive exposure to UV is widely recognized as a major factor leading to skin perturbations and cancer, the complex mechanisms underlying inflammatory skin disorders resulting from UV exposure remain incompletely characterized. The nuclear hormone receptor PPARβ/δ is known to control mouse cutaneous repair and UV-induced skin cancer development. Here, we describe a novel PPARβ/δ-dependent molecular cascade involving TGFβ1 and miR-21-3p, which is activated in the epidermis in response to UV exposure. We establish that the passenger mi RNA miR-21-3p, that we identify as a novel UV-induced mi RNA in the epidermis, plays a pro-inflammatory function in keratinocytes and that its high level of expression in human skin is associated with psoriasis and squamous cell carcinomas. Finally, we provide evidence that inhibition of miR-21-3p reduces UV-induced cutaneous inflammation in ex vivo human skin biopsies, thereby underlining the clinical relevance of mi RNA-based topical therapies for cutaneous disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17574676
- Volume :
- 8
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- EMBO Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 117108239
- Full Text :
- https://doi.org/10.15252/emmm.201505384