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1. circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

Author

Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou, Peipei Jiang, Qianwen Wu, Hui Zhu, Huiyan Wang, Chenyan Dai, Jingmei Wang, Ruotian Li, Yun Cao, Haining Lv, Dan Liu, Jianwu Dai, Yan Zhou, and Yali Hu

Subjects
endometrial epithelial cells, endometrial fibrosis, epithelial mesenchymal transition, circPTPN12, mir-21-5p, ∆Np63α, Medicine, Science, Biology (General), QH301-705.5
Abstract

Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21–5 p to inhibit miR-21–5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC–EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC–EMT and administration of miR-21–5 p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12/miR-21–5 p/∆Np63α pathway contributed to the pathogenesis of endometrial fibrosis.

Published
2021
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2. circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

Author

Ruotian Li, Simin Yao, Haixiang Sun, Zhenhua Zhou, Chenyan Dai, Minmin Song, Qianwen Wu, Jianwu Dai, Peipei Jiang, Yun Cao, Jingmei Wang, Hui Zhu, Yan Zhou, Dan Liu, Guangfeng Zhao, Huiyan Wang, Haining Lv, and Yali Hu

Subjects
0301 basic medicine, Mouse, epithelial mesenchymal transition, Protein Tyrosine Phosphatase, Non-Receptor Type 12, circPTPN12, Endogeny, Endometrium, Pathogenesis, Mice, 0302 clinical medicine, Fibrosis, Medicine, Biology (General), Cells, Cultured, Uterine Diseases, Mice, Inbred BALB C, General Neuroscience, General Medicine, ∆Np63α, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, endometrial fibrosis, Research Article, Human, Signal Transduction, Infertility, Epithelial-Mesenchymal Transition, QH301-705.5, Science, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Downregulation and upregulation, mir-21-5p, Animals, Humans, Epithelial–mesenchymal transition, Pathological, General Immunology and Microbiology, business.industry, Tumor Suppressor Proteins, Epithelial Cells, Cell Biology, RNA, Circular, medicine.disease, MicroRNAs, stomatognathic diseases, 030104 developmental biology, endometrial epithelial cells, Cancer research, Trans-Activators, business, Transcription Factors
Abstract

Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21–5 p to inhibit miR-21–5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC–EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC–EMT and administration of miR-21–5 p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12/miR-21–5 p/∆Np63α pathway contributed to the pathogenesis of endometrial fibrosis.

Published
2021

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