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circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
- Source :
- eLife, Vol 10 (2021), eLife
- Publication Year :
- 2021
- Publisher :
- eLife Sciences Publications Ltd, 2021.
-
Abstract
- Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21–5 p to inhibit miR-21–5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC–EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC–EMT and administration of miR-21–5 p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12/miR-21–5 p/∆Np63α pathway contributed to the pathogenesis of endometrial fibrosis.
- Subjects :
- 0301 basic medicine
Mouse
epithelial mesenchymal transition
Protein Tyrosine Phosphatase, Non-Receptor Type 12
circPTPN12
Endogeny
Endometrium
Pathogenesis
Mice
0302 clinical medicine
Fibrosis
Medicine
Biology (General)
Cells, Cultured
Uterine Diseases
Mice, Inbred BALB C
General Neuroscience
General Medicine
∆Np63α
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
endometrial fibrosis
Research Article
Human
Signal Transduction
Infertility
Epithelial-Mesenchymal Transition
QH301-705.5
Science
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Downregulation and upregulation
mir-21-5p
Animals
Humans
Epithelial–mesenchymal transition
Pathological
General Immunology and Microbiology
business.industry
Tumor Suppressor Proteins
Epithelial Cells
Cell Biology
RNA, Circular
medicine.disease
MicroRNAs
stomatognathic diseases
030104 developmental biology
endometrial epithelial cells
Cancer research
Trans-Activators
business
Transcription Factors
Subjects
Details
- Language :
- English
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....61a29ea5f5d4e08396c28e6bbbd08683