Back to Search Start Over

circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

Authors :
Ruotian Li
Simin Yao
Haixiang Sun
Zhenhua Zhou
Chenyan Dai
Minmin Song
Qianwen Wu
Jianwu Dai
Peipei Jiang
Yun Cao
Jingmei Wang
Hui Zhu
Yan Zhou
Dan Liu
Guangfeng Zhao
Huiyan Wang
Haining Lv
Yali Hu
Source :
eLife, Vol 10 (2021), eLife
Publication Year :
2021
Publisher :
eLife Sciences Publications Ltd, 2021.

Abstract

Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases including organ fibrosis. Endometrium fibrosis is the leading cause of uterine infertility, but the role of circRNAs in its pathogenesis is largely unknown. Here, we provide the evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR-21–5 p to inhibit miR-21–5 p expression and activity, which in turn results in upregulation of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (EEC–EMT). In a mouse model of endometrium fibrosis, circPTPN12 appears to be a cofactor of driving EEC–EMT and administration of miR-21–5 p could reverse this process and improve endometrial fibrosis. Our findings revealed that the dysfunction of circPTPN12/miR-21–5 p/∆Np63α pathway contributed to the pathogenesis of endometrial fibrosis.

Details

Language :
English
Volume :
10
Database :
OpenAIRE
Journal :
eLife
Accession number :
edsair.doi.dedup.....61a29ea5f5d4e08396c28e6bbbd08683