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Phthalocyanine derivatives have attracted attention in the photodynamic therapy of cancer. The preparation of cationic amphiphilic zinc phthalocyanine derivatives is described. Novel amphiphilic non-peripheral substituted zinc phthalocyanine derivative is performed by quaternation. Amphiphilic zinc bis(1,4-didecylbenzo)-bis(3,4-pyrido)porphyrazine will be a useful photosensitizer for photodynamic therapy of cancer. [Copyright &y& Elsevier]

The phthalocyanine analogue containing non-peripheral, long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido)porphyrazine was synthesized. The synthesized product is an interesting compound because quaternization of the pyridine nitrogen is expected to impart cationic amphiphilic character. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido)porphyrazine was reacted with dimethyl sulfate and monochloroacetic acid to produce the quaternized products and with diethyl sulfate to produce the sulfo-substituted product; all such compounds displayed amphiphilic character. Identical peaks in cyclic voltammograms were obtained for the products before and after quaternization. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido)porphyrazine had no changes in its reduction or oxidation properties compared to phthalocyanine analogues. [Copyright &y& Elsevier]

Subphthalocyanine and its derivatives which possessed substituents such as thiobutyl and thiophenyl were synthesized. These compounds were measured using spectroscopic measurements and cyclic voltammetry. Sensitization properties of synthetic subphthalocyanine (SubPC) in 2,4,6-Tris(trichloromethyl)-1,3,5-triazine as radical generation reaction in a poly(methyl methacrylate) film have been investigated by laser flash photolysis. [Copyright &y& Elsevier]