Synthesis of novel cationic amphiphilic phthalocyanine derivatives for next generation photosensitizer using photodynamic therapy of cancer

Phthalocyanine derivatives have attracted attention in the photodynamic therapy of cancer. The preparation of cationic amphiphilic zinc phthalocyanine derivatives is described. Novel amphiphilic non-peripheral substituted zinc phthalocyanine derivative is performed by quaternation. Amphiphilic zinc bis(1,4-didecylbenzo)-bis(3,4-pyrido)porphyrazine will be a useful photosensitizer for photodynamic therapy of cancer. [Copyright &y& Elsevier]