1. Highly immunogenic variant of attenuated vaccinia virus
- Author
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I. V. Kolosova, S N Yakubitskyi, Sergei N. Shchelkunov, and Rinat A. Maksyutov
- Subjects
Male ,0301 basic medicine ,viruses ,Antigen presentation ,Biophysics ,Virulence ,Hemagglutinin (influenza) ,Vaccinia virus ,Vaccines, Attenuated ,Biochemistry ,Virus ,Cell Line ,Mice ,Viral Proteins ,03 medical and health sciences ,chemistry.chemical_compound ,Immunogenicity, Vaccine ,Animals ,Orthopoxvirus ,Mice, Inbred BALB C ,Attenuated vaccine ,biology ,virus diseases ,General Chemistry ,General Medicine ,biology.organism_classification ,Virology ,030104 developmental biology ,chemistry ,Thymidine kinase ,biology.protein ,Vaccinia ,Gene Deletion ,Smallpox Vaccine - Abstract
The LIVPΔ6 strain of vaccinia virus (VACV) was created by genetic engineering on the basis of previously obtained attenuated 1421ABJCN strain by target deletion of the A35R gene encoding an inhibitor of antigen presentation by the major histocompatibility complex class II. 1421ABJCN is the LIVP strain of VACV with five inactivated virulence genes encoding hemagglutinin (A56R), γ-interferon-binding protein (B8R), thymidine kinase (J2R), complement-binding protein (C3L), and Bcl2-like inhibitor of apoptosis (N1L). The highly immunogenic LIVPΔ6 strain could be an efficient fourth-generation attenuated vaccine against smallpox and other orthopoxvirus infections.
- Published
- 2016
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