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Highly immunogenic variant of attenuated vaccinia virus

Authors :
I. V. Kolosova
S N Yakubitskyi
Sergei N. Shchelkunov
Rinat A. Maksyutov
Source :
Doklady Biochemistry and Biophysics. 466:35-38
Publication Year :
2016
Publisher :
Pleiades Publishing Ltd, 2016.

Abstract

The LIVPΔ6 strain of vaccinia virus (VACV) was created by genetic engineering on the basis of previously obtained attenuated 1421ABJCN strain by target deletion of the A35R gene encoding an inhibitor of antigen presentation by the major histocompatibility complex class II. 1421ABJCN is the LIVP strain of VACV with five inactivated virulence genes encoding hemagglutinin (A56R), γ-interferon-binding protein (B8R), thymidine kinase (J2R), complement-binding protein (C3L), and Bcl2-like inhibitor of apoptosis (N1L). The highly immunogenic LIVPΔ6 strain could be an efficient fourth-generation attenuated vaccine against smallpox and other orthopoxvirus infections.

Details

ISSN :
16083091 and 16076729
Volume :
466
Database :
OpenAIRE
Journal :
Doklady Biochemistry and Biophysics
Accession number :
edsair.doi.dedup.....90cd446a19c618e44f5bb27244ee56c9
Full Text :
https://doi.org/10.1134/s1607672916010105