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Highly immunogenic variant of attenuated vaccinia virus
- Source :
- Doklady Biochemistry and Biophysics. 466:35-38
- Publication Year :
- 2016
- Publisher :
- Pleiades Publishing Ltd, 2016.
-
Abstract
- The LIVPΔ6 strain of vaccinia virus (VACV) was created by genetic engineering on the basis of previously obtained attenuated 1421ABJCN strain by target deletion of the A35R gene encoding an inhibitor of antigen presentation by the major histocompatibility complex class II. 1421ABJCN is the LIVP strain of VACV with five inactivated virulence genes encoding hemagglutinin (A56R), γ-interferon-binding protein (B8R), thymidine kinase (J2R), complement-binding protein (C3L), and Bcl2-like inhibitor of apoptosis (N1L). The highly immunogenic LIVPΔ6 strain could be an efficient fourth-generation attenuated vaccine against smallpox and other orthopoxvirus infections.
- Subjects :
- Male
0301 basic medicine
viruses
Antigen presentation
Biophysics
Virulence
Hemagglutinin (influenza)
Vaccinia virus
Vaccines, Attenuated
Biochemistry
Virus
Cell Line
Mice
Viral Proteins
03 medical and health sciences
chemistry.chemical_compound
Immunogenicity, Vaccine
Animals
Orthopoxvirus
Mice, Inbred BALB C
Attenuated vaccine
biology
virus diseases
General Chemistry
General Medicine
biology.organism_classification
Virology
030104 developmental biology
chemistry
Thymidine kinase
biology.protein
Vaccinia
Gene Deletion
Smallpox Vaccine
Subjects
Details
- ISSN :
- 16083091 and 16076729
- Volume :
- 466
- Database :
- OpenAIRE
- Journal :
- Doklady Biochemistry and Biophysics
- Accession number :
- edsair.doi.dedup.....90cd446a19c618e44f5bb27244ee56c9
- Full Text :
- https://doi.org/10.1134/s1607672916010105