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A recent study conducted at Changchun University of Technology in China focused on the use of nanofibers to promote wound healing in diabetic patients. The research highlighted the challenges of healing diabetic wounds due to bacterial infections caused by elevated blood glucose levels. The study found that nanofiber membranes with a radially oriented structure showed promising results in promoting cell proliferation, adhesion, and wound healing, indicating potential applications in chronic diabetic wound care. The research has been peer-reviewed and offers valuable insights into the use of nanotechnology in healthcare. [Extracted from the article]

Researchers at Jilin Agricultural University in Changchun, China, have developed Zeolitic Imidazolate Framework-8 (ZIF-8) nanocomposite hydrogels loaded with dihydroquercetin (DHQ) for diabetic wound healing. The hydrogel showed promising in vitro antioxidant activity, inhibition of bacteria, and promotion of cell growth and migration. In vivo experiments demonstrated that the hydrogel promotes wound healing by inhibiting specific pathways and stimulating skin neovascularization. This research suggests that ZIF-8 nanocomposite hydrogels could be effective for diabetic wound dressings and long-term tissue repair applications. [Extracted from the article]

A recent report from Changchun University of Chinese Medicine discusses the effectiveness of acupuncture in treating diabetic nephropathy. The study included 13 trials with a total of 899 participants and found that acupuncture combined with modern medical treatment improved urinary albumin excretion and interleukin-6 levels in patients with diabetic nephropathy. However, more large-scale, randomized controlled trials are needed to further evaluate the safety and efficacy of acupuncture in treating this condition. [Extracted from the article]

Researchers at Jilin University in Changchun, People's Republic of China, conducted a study on the molecular mechanisms underlying the improvement of glucose metabolism in type 2 diabetic rats through metabolic surgery. The study focused on the effectiveness of Single-anastomosis duodenal-ileal bypass with sleeve gastrectomy (SADI-S) in treating type 2 diabetes mellitus (T2DM). The research identified differentially expressed genes and proteins in liver tissues of T2DM rats that underwent SADI-S, suggesting potential pathways for the alleviation of T2DM. The study was peer-reviewed and provides valuable insights into the impact of metabolic surgery on glucose metabolism. [Extracted from the article]

A study conducted at the First Hospital of Jilin University in Changchun, People's Republic of China, explored the relationship between hypertensive disorders of pregnancy (HDP) and stroke risk using genetic data. The research found that genetically predicted HDP was associated with an increased risk of different types of strokes, including large artery atherosclerosis and small vessel stroke. The study concluded that type 2 diabetes mellitus and hypertension play significant roles in the association between HDP and stroke, highlighting HDP as a risk factor for cerebrovascular diseases. [Extracted from the article]

Researchers at the First Hospital of Jilin University in Changchun, People's Republic of China, have developed a semaglutide-loaded nanofiber membrane to promote diabetic wound healing by suppressing reactive oxygen species production and accelerating angiogenesis in a diabetic rat model. The membrane, prepared using an electrostatic spinning technique, showed promising results in promoting normal skin structure formation in regenerated tissue and inhibiting ROS production in endothelial cells. This study provides a theoretical basis for the potential application of semaglutide in treating diabetic ulcers and other wounds. [Extracted from the article]

A recent study conducted at Changchun University of Chinese Medicine focused on the effects of Jiawei Wumei Wan (JWWMW) in treating renal fibrosis in diabetic nephropathy (DN) in mice. The research found that JWWMW improved renal fibrosis in DN mice by regulating the PI3K/AKT/mTOR signaling pathway, thus preventing and treating renal fibrosis. The study provides a scientific and theoretical approach to the clinical application of JWWMW in treating DN. [Extracted from the article]

A recent study conducted at Jilin University in Changchun, China, has developed a fluorescent probe called CHQ-B that can be used to visualize the distribution and activity of the enzyme butyrylcholinesterase (BChE) in living cells and diabetic mouse models. BChE is known to be associated with various diseases, and monitoring its expression in vivo can provide insights into the physiological effects of BChE and improve disease prevention, diagnosis, and therapy. The probe demonstrated high selectivity and sensitivity towards BChE, as well as low cytotoxicity and good biocompatibility. The study concluded that CHQ-B is a promising tool for exploring the expression of BChE in organisms and its relationship with various diseases. [Extracted from the article]

A study conducted by researchers at Jilin University in Changchun, China, has developed an intelligent multi-responsive nanofibrous dressing to promote wound closure in diabetic wounds. The dressing, made of polytrimethylene carbonate (PTMC)/polyvinylpyrrolidone (PVP) nanofibers loaded with simvastatin-loaded ZIF-8 nanoparticles, exhibited liquid-triggered and temperature-controlled shrinkage characteristics, as well as pH-responsive drug release properties. In vitro and in vivo experiments demonstrated that the dressing had favorable biocompatibility, proangiogenic properties, and inhibitory effects against bacteria. The researchers concluded that the dressing has great potential for the treatment of chronic wounds. [Extracted from the article]

A recent study conducted at the Second Hospital of Jilin University in Changchun, China, explores the use of conductive hydrogels as a potential treatment for diabetic wounds. Diabetic wounds are a serious complication of diabetes mellitus, and traditional treatments often have limited effectiveness. The researchers suggest that incorporating conductive materials into hydrogels can enhance their therapeutic effects by promoting nerve and vascular regeneration, accelerating hemostasis, and enhancing anti-inflammatory and antibacterial effects. Conductive hydrogels show promise as a potential treatment for diabetic wounds, but further research is needed in this field. [Extracted from the article]

A recent research study conducted at the Chinese Academy of Sciences in Changchun, People's Republic of China, has developed a dual-crosslinked antibacterial hydrogel for the treatment of diabetic foot ulcers. Diabetic foot ulcers are a significant burden on the healthcare system due to their high incidence and the risk of chronic inflammation and delayed wound healing. The hydrogel, loaded with an anti-inflammatory compound called asiaticoside, demonstrated suitable gelation properties, good biocompatibility, and exceptional antibacterial activity. In a rat model of diabetic foot ulcers, the hydrogel was found to alleviate inflammation, promote angiogenesis, and accelerate wound healing. This research has been peer-reviewed and shows considerable potential for diabetic wound healing. [Extracted from the article]

Researchers from Jilin University in Changchun, China have developed a new liposome-based therapy for type 2 diabetes. The therapy involves a ginsenoside called G-Rg3, which has been shown to improve insulin sensitivity and reduce cell apoptosis in diabetes treatment. However, the low oral availability of G-Rg3 has limited its application. The researchers designed a PEGylated long-circulating liposome called PEG-L-Rg3, which demonstrated efficient ability to improve body weight, food intake, fasting insulin, insulin sensitivity, and glucose tolerance in type 2 diabetic mice. This study provides a potential new treatment option for type 2 diabetes using ginsenosides. [Extracted from the article]

A study conducted by researchers at Changchun Normal University in China has found that a hydrogel made from Bletilla striata polysaccharide (BSP) and hyaluronic acid (HA) can effectively administer tetramethylpyrazine (TMP) for diabetic wound therapy. The hydrogel formulation, called TMP-BSP-HA, was shown to promote inflammation reduction, blood vessel growth, and collagen deposition, leading to accelerated wound healing in mice with diabetes. The study suggests that this hydrogel-based approach could be a promising alternative for diabetic wound treatment. The research was supported by the Department of Science and Technology of Jilin Province. [Extracted from the article]

A recent report from researchers at Jilin Agricultural University in Changchun, China, discusses the development of a hydrogel dressing for diabetic wounds. The dressing, made from a combination of Gastrodia elata polysaccharide and drug-carrying microspheres, demonstrated antibacterial, antioxidant, and hemostatic properties. In experiments with mice, the hydrogel dressing significantly accelerated wound healing in a high-sugar environment. The researchers believe that the dressing promotes angiogenesis, reduces inflammation, and increases tissue remodeling. This study suggests that the hydrogel dressing has potential for use in chronic diabetic wound repair. [Extracted from the article]

A report from Changchun University of Chinese Medicine in the People's Republic of China evaluated the efficacy and safety of Huangkui capsule (HKC) in the treatment of diabetic nephropathy (DN). The researchers conducted a systematic review and meta-analysis of randomized controlled trials of HKC for DN treatment. The analysis included 45 studies with a total sample size of 4297 cases. The results showed that HKC had a better clinical efficacy and safety profile compared to conventional western medicine alone. However, the researchers emphasized the need for more rigorously designed large-sample, multicenter randomized controlled trials to provide further evidence. [Extracted from the article]

Researchers from the First Hospital of Jilin University in Changchun, China have developed a new therapy for treating infected diabetic wounds. The therapy, based on hemoglobin bionics, utilizes a glucose/pH-responsive microneedle bandage to deliver an "iron cargo" that disrupts bacterial iron homeostasis. This approach effectively combats antibiotic resistance and accelerates tissue recovery. The research holds potential for mediating microbial-host interactions and reducing pathogen virulence. [Extracted from the article]

A recent study conducted by researchers at Jilin University in Changchun, China, has found that the drug irbesartan may be effective in treating diabetic nephropathy, a kidney disease caused by diabetes. The study discovered that irbesartan activates the Nrf2/keap1 pathway and suppresses the Nlrp3 inflammasomes, leading to improved kidney function and reduced inflammation. These findings provide new therapeutic strategies for the treatment of diabetic nephropathy. The research was supported by the Jilin Scientific and Technological Development Program and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Jilin University in Changchun, China has developed a glucose-responsive hydrogel dressing system that effectively treats methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rats and enhances wound healing. The hydrogel is synthesized using copper nanoclusters cross-linked with oxidized hyaluronic acid and decorated with glucose oxidase. This dressing system reduces glucose levels within the wound, establishes a sterile environment, and promotes blood vessel formation, making it a promising option for treating complex diabetic wounds. The research has been peer-reviewed and published in the Chemical Engineering Journal. [Extracted from the article]

A recent study conducted by the Chinese Academy of Sciences investigated the therapeutic effects of Tribulus Terrestris L. (TT) on type 2 diabetes. The study aimed to understand the underlying mechanisms and comprehensive effects of TT on diabetes. The research found that TT exhibited a significant therapeutic effect on type 2 diabetes rats, improving glucolipid metabolism, intestinal barrier integrity, inflammation, and insulin resistance. The study also revealed that TT modulated the gut microbiota and its metabolites, which may contribute to its anti-diabetic capacity. Overall, the multiple components of TT were found to regulate metabolic homeostasis and the balance of intestinal microbiota. [Extracted from the article]

A recent study conducted by researchers at Northeast Normal University in Changchun, China, has investigated the potential therapeutic value of a polysaccharide called mannogalactoglucan, derived from mushrooms, in treating type 1 diabetes mellitus (T1DM). The study found that mannogalactoglucan, specifically the neutral fraction of alkali-soluble Armillaria mellea polysaccharide (AAMP-N), was able to lower blood glucose levels and improve diabetes symptoms in T1DM mice. The researchers discovered that AAMP-N activated the unfolded protein response (UPR) signaling pathway, promoted insulin synthesis, increased calcium signals, and enhanced insulin secretory vesicle fusion with the plasma membrane. These findings suggest that mannogalactoglucan could be a natural nutraceutical for the treatment of T1DM. [Extracted from the article]

A study conducted at the First Hospital of Jilin University in Changchun, China, has found that the drug clopidogrel may have a protective effect against diabetic cardiomyopathy (DCM). The study was conducted on db/db mice, which were administered different doses of clopidogrel for five months. The results showed that clopidogrel effectively reduced cardiac hypertrophy and dysfunction caused by diabetes by inhibiting cardiac fibrosis, inflammatory responses, and oxidative stress damage. The study suggests that clopidogrel could be a promising treatment for DCM. [Extracted from the article]

A study conducted by investigators from Jilin Agricultural University in Changchun, People's Republic of China, explores the therapeutic effects of a walnut-derived peptide on NLRP3 inflammasome activation, synaptic plasticity, and cognitive dysfunction in type 2 diabetes mellitus (T2DM) mice. The researchers found that the walnut-derived peptide, TW-7, alleviated cognitive deficits in mice and improved synaptic structure and dendritic spine density in the hippocampus. TW-7 also suppressed the NEK7/NLRP3 inflammatory pathway and improved synaptic plasticity. The study suggests that NLRP3 inflammasome activation plays a key role in the development of diabetes-induced cognitive impairment. [Extracted from the article]

Researchers from Jilin Agricultural University in Changchun, China have developed a new method for treating diabetic wounds. The study focused on addressing issues such as inflammation, bacterial infection, bleeding, and wound exudate accumulation, which can hinder the healing process. The researchers created multifunctional electrospun fibrous membranes (EFMs) that contained Taxifolin (TAX) loaded onto cyclodextrin metal-organic frameworks (CD-MOFs). These EFMs demonstrated antimicrobial, anti-inflammatory, hemostatic, and wound exudate-absorbent properties, promoting wound healing in diabetic mice. This research provides a potential new strategy for the treatment of diabetic wounds. [Extracted from the article]

A new report from the Second Hospital of Jilin University in Changchun, China, explores the causal relationship between diabetic nephropathy (DN) and age-related macular degeneration (AMD) among individuals of European descent. The study utilized genetic variants associated with DN and its risk factors, as well as data from the FinnGen database, to conduct Mendelian randomization analyses. The findings suggest that DN increases the risk of overall AMD, as well as dry and wet AMD. Additionally, elevated levels of high-density lipoprotein-cholesterol (HDL-C) were found to heighten the risk of AMD, while triglycerides were associated with a protective effect. [Extracted from the article]

A study conducted by researchers at Changchun University of Technology in China has developed a novel self-pumping dressing for diabetic wound healing. The dressing consists of a hydrophobic layer with a drainage agent and a fluffy 3D nanofiber cotton absorbent layer. The dressing promotes unidirectional drainage of inflammatory exudate and regulation of macrophage polarization, leading to faster wound healing. The researchers found that the dressing increased the mobilization of M2 macrophages, accelerated the transition from the inflammatory to the proliferative phase, and promoted collagen remodeling and skin appendage formation. This research has important clinical implications for accelerating diabetic wound healing. [Extracted from the article]

A study conducted at the First Hospital of Jilin University in Changchun, China, has found that tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (4-PBA) can improve the oxidative stress of the endoplasmic reticulum in mice with type 1 diabetes (T1D). The researchers used streptozotocin to induce T1D in mice and administered TUDCA or 4-PBA. They found that both substances reduced glucose and glycated serum protein levels and normalized selenium levels in various tissues. The study suggests that further research is needed to understand the mechanisms behind these effects. [Extracted from the article]

Changchun, People's Republic of China, Asia, Life Science, Endothelial Cells, Health and Medicine, Podocytes Keywords: Changchun; People's Republic of China; Asia; Life Science; Endothelial Cells; Health and Medicine; Podocytes EN Changchun People's Republic of China Asia Life Science Endothelial Cells Health and Medicine Podocytes 398 398 1 10/30/23 20231030 NES 231030 2023 OCT 30 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- Fresh data on Life Science are presented in a new report. [Extracted from the article]

Keywords: Changchun; People's Republic of China; Asia; Biomarkers; Diagnostics and Screening; Health and Medicine; Peptide Hormones; Peptide Proteins; Proinsulin EN Changchun People's Republic of China Asia Biomarkers Diagnostics and Screening Health and Medicine Peptide Hormones Peptide Proteins Proinsulin 313 313 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- A new study on Diagnostics and Screening - Biomarkers is now available. Keywords for this news article include: Changchun, People's Republic of China, Asia, Biomarkers, Diagnostics and Screening, Health and Medicine, Peptide Hormones, Peptide Proteins, Proinsulin, Jilin University. [Extracted from the article]

People's Republic of China, Asia, Antibacterials, Antibiotics, Antimicrobials, Diabetes Complications, Diabetes Mellitus, Diabetic Angiopathies, Diabetic Foot, Diabetic Neuropathy, Drugs and Therapies, Endocrine System Diseases and Conditions, Foot Ulcers, Health and Medicine, Leg Ulcers, Nutritional and Metabolic Diseases and Conditions, Skin Diseases and Conditions, Skin Ulcers, Skin and Connective Tissue Diseases and Conditions, Therapy, Ulcers, Vascular Diseases and Conditions, Changchun Keywords: Changchun; People's Republic of China; Asia; Antibacterials; Antibiotics; Antimicrobials; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Foot; Diabetic Neuropathy; Drugs and Therapies; Endocrine System Diseases and Conditions; Foot Ulcers; Health and Medicine; Leg Ulcers; Nutritional and Metabolic Diseases and Conditions; Skin Diseases and Conditions; Skin Ulcers; Skin and Connective Tissue Diseases and Conditions; Therapy; Ulcers; Vascular Diseases and Conditions EN Changchun People's Republic of China Asia Antibacterials Antibiotics Antimicrobials Diabetes Complications Diabetes Mellitus Diabetic Angiopathies Diabetic Foot Diabetic Neuropathy Drugs and Therapies Endocrine System Diseases and Conditions Foot Ulcers Health and Medicine Leg Ulcers Nutritional and Metabolic Diseases and Conditions Skin Diseases and Conditions Skin Ulcers Skin and Connective Tissue Diseases and Conditions Therapy Ulcers Vascular Diseases and Conditions 78 78 1 06/19/23 20230619 NES 230619 2023 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- Data detailed on Skin Diseases and Conditions - Foot Ulcers have been presented. [Extracted from the article]

Macrophage activation acts as an inflammatory response, which is characterized by macrophage recruitment in the initial stage." Keywords: Changchun; People's Republic of China; Asia; Bariatrics; Connective Tissue Cells; DNA-Binding Proteins; Diet and Nutrition; Endocrine System Diseases and Conditions; Ginsenosides; Glucose Metabolism Disorders; Health and Medicine; Hyperinsulinism; Immunology; Inflammation; Insulin Resistance; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Non-Insulin Dependent Diabetes Mellitus; Nutrition Disorders; Nutritional and Metabolic Diseases and Conditions; Obesity; Obesity and Diabetes; Overnutrition; PPAR gamma; Peptide Hormones; Peptide Proteins; Peroxisome Proliferator-Activated Receptors; Phagocytes; Proinsulin; Proteins; Transcription Factors; Triterpenes; Type 2 Diabetes EN Changchun People's Republic of China Asia Bariatrics Connective Tissue Cells DNA-Binding Proteins Diet and Nutrition Endocrine System Diseases and Conditions Ginsenosides Glucose Metabolism Disorders Health and Medicine Hyperinsulinism Immunology Inflammation Insulin Resistance Macrophages Mononuclear Phagocyte System Myeloid Cells Non-Insulin Dependent Diabetes Mellitus Nutrition Disorders Nutritional and Metabolic Diseases and Conditions Obesity Obesity and Diabetes Overnutrition PPAR gamma Peptide Hormones Peptide Proteins Peroxisome Proliferator-Activated Receptors Phagocytes Proinsulin Proteins Transcription Factors Triterpenes Type 2 Diabetes 32 32 1 05/29/23 20230529 NES 230529 2023 MAY 29 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- Investigators publish new report on Nutritional and Metabolic Diseases and Conditions - Type 2 Diabetes. [Extracted from the article]

Keywords: Changchun; People's Republic of China; Asia; Endocrine System Diseases and Conditions; Enzymes and Coenzymes; Glucose Metabolism Disorders; Health and Medicine; Hyperinsulinism; Insulin Resistance; Kinase; Nutritional and Metabolic Diseases and Conditions; Peptide Hormones; Peptide Proteins; Proinsulin EN Changchun People's Republic of China Asia Endocrine System Diseases and Conditions Enzymes and Coenzymes Glucose Metabolism Disorders Health and Medicine Hyperinsulinism Insulin Resistance Kinase Nutritional and Metabolic Diseases and Conditions Peptide Hormones Peptide Proteins Proinsulin 227 227 1 05/08/23 20230508 NES 230508 2023 MAY 8 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- A new study on Endocrine System Diseases and Conditions - Insulin Resistance is now available. People's Republic of China, Asia, Endocrine System Diseases and Conditions, Enzymes and Coenzymes, Glucose Metabolism Disorders, Health and Medicine, Hyperinsulinism, Insulin Resistance, Kinase, Nutritional and Metabolic Diseases and Conditions, Peptide Hormones, Peptide Proteins, Proinsulin, Changchun Keywords for this news article include: Changchun, People's Republic of China, Asia, Endocrine System Diseases and Conditions, Enzymes and Coenzymes, Glucose Metabolism Disorders, Health and Medicine, Hyperinsulinism, Insulin Resistance, Kinase, Nutritional and Metabolic Diseases and Conditions, Peptide Hormones, Peptide Proteins, Proinsulin, Northeast Normal University. [Extracted from the article]

Keywords for this news article include: Changchun, People's Republic of China, Asia, Diabetes Mellitus, Drugs and Therapies, Endocrine System Diseases and Conditions, Endocrinology, Glucose Metabolism Disorders, Health and Medicine, Metabolic Diseases and Conditions, Nutritional and Metabolic Diseases and Conditions, Jilin Agricultural University. Keywords: Changchun; People's Republic of China; Asia; Diabetes Mellitus; Drugs and Therapies; Endocrine System Diseases and Conditions; Endocrinology; Glucose Metabolism Disorders; Health and Medicine; Metabolic Diseases and Conditions; Nutritional and Metabolic Diseases and Conditions EN Changchun People's Republic of China Asia Diabetes Mellitus Drugs and Therapies Endocrine System Diseases and Conditions Endocrinology Glucose Metabolism Disorders Health and Medicine Metabolic Diseases and Conditions Nutritional and Metabolic Diseases and Conditions 34 34 1 03/24/23 20230306 NES 230306 2023 MAR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- A new study on Nutritional and Metabolic Diseases and Conditions - Diabetes Mellitus is now available. [Extracted from the article]

The article discusses research which investigated the effect of schisandrin on streptozotocin combining with high fat diet (STZ/HFD)-induced dia- betic nephropathy (DN) in mice via regulation of phosphatidylinositol 3 kinase (Pi3k)/protein kinase B (akt)/ nuclear factor (Nf)-kappa B-mediated inflammation and transforming growth factor (Tgf)-beta 1-induced fibrosis in high fat diet (HfD).