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Start Over Author "Maria Gschwandtner" Journal current medical science
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1. Cerebellar Degeneration-related Antigen 1 Is Ubiquitously Expressed in Human Epidermis and Dermis

Author

Lu-lu Wang, Erwin Tschachler, Leopold Eckhart, and Maria Gschwandtner

Subjects
Nervous system, Adult, Keratinocytes, Male, Nerve Tissue Proteins, Biology, Biochemistry, Autoantigens, Young Adult, Antigen, Dermis, Genetics, medicine, Cerebellar Degeneration, Humans, RNA, Messenger, Cells, Cultured, Aged, Skin, Messenger RNA, Fibroblasts, Middle Aged, Mast cell, Cell biology, medicine.anatomical_structure, Melanocytes, Female, Epidermis, Keratinocyte
Abstract

Cerebellar degeneration-related antigen 1 (CDR1) was described to be expressed in the nervous system and in different types of cancer tissues. In the present study, we demonstrate that CDR1 is in addition ubiquitously expressed in human epidermis, dermis and isolated skin cells. Both CDR1 mRNA and protein were detected in human skin-derived mast cells, melanocytes, fibroblasts and keratinocytes, suggesting that CDR1 does not have a neuron-specific function.

Published
2019

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