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A research study conducted at Central China Normal University in Wuhan, People's Republic of China, examined the temporal characteristics of clinical citations in biomedical papers. The study analyzed over 23 million biomedical papers in PubMed from 1940 to 2013. The results showed that highly clinically cited papers had an advantage in receiving clinical citations compared to medium and lowly clinically cited papers. Additionally, papers closer to clinical science were more likely to receive clinical citations than those closer to basic science. The findings of this study may be useful for pharmaceutical companies, government policy-makers, and young scholars in biomedicine. [Extracted from the article]

Researchers at Maurizio Bufalini Hospital have published a position paper on surgical stabilization of rib fractures (SSRF), endorsed by the World Society of Emergency Surgery and supported by the Chest Wall Injury Society. The paper aims to provide a comprehensive review of the literature on SSRF, offering graded position statements on key aspects of rib fracture management. The consensus document addresses indications, timing, operative planning, approaches, and techniques for SSRF, with the goal of guiding clinicians to optimize patient outcomes and direct future research. The research involved a thorough literature review and input from an international panel of experts. [Extracted from the article]

A study examining the prevalence of problematic papers in non-coding RNA (ncRNA) research found that around 1.79% of papers have been retracted and an additional 5.68% have raised concerns on PubPeer. The number of problematic papers has steadily increased, with concerning and retraction rates peaking in 2019 at nearly 10.8% and 3.7% respectively. These unreliable papers have been widely cited in academic literature, patents, clinical trials, and policy documents, posing a threat to research integrity and public health. The main issues identified include image manipulation, data falsification, fake peer reviews, and ethical lapses. The study calls for urgent scrutiny of ncRNA publications and broader reforms to address systemic problems in research. [Extracted from the article]

Researchers from the University of North Texas have conducted a review paper on the potential use of photobiomodulation (PBM) as a non-invasive therapeutic option for Alzheimer's disease. The paper highlights the limitations of current pharmacological interventions and explores how PBM, which uses infrared light to promote cellular repair and regeneration, could be a safe and effective alternative treatment for Alzheimer's disease. The findings suggest that further research and clinical trials are needed to establish the therapeutic efficacy of PBM conclusively. [Extracted from the article]

A recent study conducted by the Androgen Society at Beth Israel Deaconess Medical Center in Boston, Massachusetts, examined the cardiovascular risks associated with testosterone therapy (TTh). The study, in response to the TRAVERSE trial results, found no increased risk of major adverse cardiovascular events (MACE) in men who received TTh compared to those who received a placebo. The Androgen Society concluded that TTh is not linked to a higher risk of heart attack, stroke, or cardiovascular death based on their findings. The research has been peer-reviewed and published in Mayo Clinic Proceedings. [Extracted from the article]

Researchers at Shenyang Pharmaceutical University in the People's Republic of China have developed a new synthetic process for the clinical candidate TMP195, a selective inhibitor of class IIa histone deacetylase. The new process allows for multigram-scale synthesis of TMP195 with increased efficiency and environmental friendliness compared to previous methods. This research has been peer-reviewed and offers a promising advancement in the field of nucleoproteins. [Extracted from the article]

A recent position paper by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Coeliac Disease (SIG-CD) provides an update on the 2016 recommendations regarding early diet and the risk of coeliac disease (CD). The paper states that breastfeeding does not reduce the risk of developing CD, and introducing gluten into an infant's diet between 4 months and 12 months of age does not affect the cumulative incidence of CD. However, consuming a high amount of gluten during weaning and early childhood years may be associated with an increased risk for CD. The paper concludes that specific recommendations on the amount and type of gluten-containing foods to be introduced at weaning are currently unjustifiable for the general population and infants with known risk types. [Extracted from the article]

Santa Catarina, Brazil, South America, Clinical Research, Clinical Trials and Studies, Dental Diseases and Conditions, Dental Fluorosis, Dentistry, Epidemiology, Health and Medicine Keywords: Santa Catarina; Brazil; South America; Clinical Research; Clinical Trials and Studies; Dental Diseases and Conditions; Dental Fluorosis; Dentistry; Epidemiology; Health and Medicine EN Santa Catarina Brazil South America Clinical Research Clinical Trials and Studies Dental Diseases and Conditions Dental Fluorosis Dentistry Epidemiology Health and Medicine 1172 1172 1 06/05/23 20230605 NES 230605 2023 JUN 5 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Dental Diseases and Conditions - Dental Fluorosis. [Extracted from the article]

A consensus paper by the Italian Sarcoma Group provides clinical recommendations for the treatment of localized angiosarcoma, a rare and aggressive vascular sarcoma. The paper highlights the unique challenges in managing angiosarcoma compared to other sarcomas and emphasizes the need for dedicated clinical recommendations. The Italian Sarcoma Group organized a consensus meeting to develop these recommendations, aiming to standardize and harmonize clinical practices for the optimal approach to localized angiosarcoma. The research concludes that further investigation through clinical trials is necessary to address uncertainties in the management of the disease. [Extracted from the article]

For more information on this research see: Study within a trial of electronic versus paper-based Patient-Reported oUtcomes CollEction (SPRUCE): study protocol for a partially randomised patient preference study. SPRUCE aims to assess acceptability of ePRO in oncology clinical trials, establish whether ePRO is acceptable to ICR-CTSU trial participants and can capture complete PRO data, consistent with paper PROs. [Extracted from the article]

A study conducted at the University of Yaounde I in Cameroon aimed to evaluate the impact of a digital cartoon educative video on the medication adherence of hypertensive patients. The study enrolled 110 patients and randomized them into two groups: one receiving standard paper-based clinical counseling and the other receiving the same counseling plus a digital cartoon video. The primary outcome measured was medication adherence after three months. The results showed that the group receiving the digital cartoon video had a higher proportion of patients with good treatment adherence compared to the standard group. The study suggests that digital cartoon videos can have a positive effect on the treatment adherence of hypertensive patients. [Extracted from the article]

A joint position paper on molecular tumor boards (MTBs) in Taiwan has been published by the Taiwan Oncology Society (TOS) and the Taiwan Society of Pathology (TSP). The paper, formulated by 20 experts from TOS and TSP, aims to raise awareness of MTBs among healthcare professionals, policymakers, and the public. The paper proposes key recommendations for MTB discussions, including the incorporation of diverse molecular analyses, involvement of multidisciplinary participants, prioritization of cases with unique clinical needs, and the use of comprehensive patient data. The primary goal of this initiative is to promote the advancement of precision oncology in Taiwan. [Extracted from the article]

The article discusses the effects of chemotherapy on skeletal muscle mitochondrial oxidative capacity in patients with breast and gynecological cancer. Chemotherapy-associated cachexia can lead to metabolic disturbances and muscle loss, impacting patients' quality of life and physical functioning. The study aims to use Near-Infrared Spectroscopy (NIRS) to assess mitochondrial function in skeletal muscle during chemotherapy treatment, with the goal of providing valuable data for future research and scientific community dissemination. This preprint has not yet undergone peer review. [Extracted from the article]

A clinical trial, NCT06474611, has been launched to evaluate the impact of sending electronic reminder messages to patients who qualify for lung cancer screening. The trial aims to determine if these reminders increase engagement in screening among eligible patients who have not previously been screened and have an upcoming appointment with their doctor. The trial is being conducted by Kaiser Permanente and is part of their efforts to expand lung cancer screening participation. The primary objective of the trial is to evaluate the effectiveness of a 2-arm electronic message outreach intervention. [Extracted from the article]

HanxBio has published a research paper titled "Narazaciclib, a novel multikinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models" in the journal Scientific Reports. The paper describes the preclinical evaluation of Narazaciclib (HX301) for the treatment of acute myeloid leukemia (AML). The researchers conducted comprehensive pharmacology characterization of HX301 using various preclinical experimental AML models, demonstrating its strong anti-leukemia activity and potential mechanisms of action. The study also investigated the pharmacodynamics and pharmacokinetics of HX301, providing valuable information for clinical dosage selection. The results of this study will guide the clinical development strategies for HX301 in the treatment of AML. [Extracted from the article]

Florianopolis, Brazil, South America, Anions, Clinical Research, Clinical Trials and Studies, Dental Caries, Dental Cavities, Dental Diseases and Conditions, Dentistry, Fluorides, Health and Medicine, Hydrofluoric Acid, Risk and Prevention, Tooth Demineralization, Tooth Diseases and Conditions Keywords: Florianopolis; Brazil; South America; Anions; Clinical Research; Clinical Trials and Studies; Dental Caries; Dental Cavities; Dental Diseases and Conditions; Dentistry; Fluorides; Health and Medicine; Hydrofluoric Acid; Risk and Prevention; Tooth Demineralization; Tooth Diseases and Conditions EN Florianopolis Brazil South America Anions Clinical Research Clinical Trials and Studies Dental Caries Dental Cavities Dental Diseases and Conditions Dentistry Fluorides Health and Medicine Hydrofluoric Acid Risk and Prevention Tooth Demineralization Tooth Diseases and Conditions 1818 1818 1 11/06/23 20231106 NES 231106 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators publish new report on Dental Diseases and Conditions - Dental Caries. [Extracted from the article]

A new paper led by Harvard researchers proposes standards and clinical tools for biomarkers of aging. The team analyzed omic data from population-based studies to identify biomarkers that can predict longevity and quality of life. They emphasize the need for standardized evaluation and validation of biomarkers related to aging, as well as expanding the focus beyond mortality to include other health outcomes. The researchers also call for collaborations among research groups and the standardization of omic data to improve reliability. Insilico Medicine, an AI-driven drug discovery company, has been developing biomarkers of aging using deep learning methods. [Extracted from the article]