1. Intraocular pressure and visual field changes in normal-tension glaucoma patients treated using either unoprostone or latanoprost: a prospective comparative study
- Author
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Shinji Ohkubo, Sachiko Udagawa, Kazuhisa Sugiyama, Daisuke Takemoto, Yoshiaki Saito, Tomomi Higashide, and Hisashi Takeda
- Subjects
visual field ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Glaucoma ,unoprostone ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Normal tension glaucoma ,Ophthalmology ,Medicine ,030212 general & internal medicine ,Latanoprost ,Prospective cohort study ,Original Research ,medicine.diagnostic_test ,business.industry ,normal-tension glaucoma ,Fundus photography ,Clinical Ophthalmology ,medicine.disease ,eye diseases ,Visual field ,chemistry ,Unoprostone ,latanoprost ,030221 ophthalmology & optometry ,sense organs ,business ,medicine.drug ,intraocular pressure - Abstract
Daisuke Takemoto, Tomomi Higashide, Yoshiaki Saito, Shinji Ohkubo, Sachiko Udagawa, Hisashi Takeda, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: We conducted a prospective study in patients with normal-tension glaucoma (NTG) who received either isopropyl unoprostone or latanoprost. We compared the drugs in terms of their effects on intraocular pressure (IOP) and visual field loss progression over a 3-year period. Study design: Prospective, randomized controlled study. Methods: We enrolled 48 patients with newly diagnosed NTG at Kanazawa University Hospital. Eligible patients were randomly allocated (1:1) to receive either unoprostone or latanoprost ophthalmic solutions. The primary outcomes were IOP changes and visual field deterioration within 36 months. Visual field changes were analyzed: the cumulative survival rates were calculated in terms of mean deviation, pattern standard deviation, and total deviation of the upper or lower hemi-visual field, each visual field sector, and guided progression analysis. In addition, we evaluated the progression of glaucomatous optic disc changes using fundus photography and confocal scanning laser ophthalmoscopy. Results: The mean pretreatment IOP was 15.0±2.4 mmHg in the Unoprostone group and 15.2±1.9 mmHg in the Latanoprost group. The mean IOP during the treatment period was 13.7±2.3 mmHg in the Unoprostone group and 13.0±1.8 mmHg in the Latanoprost group. In both groups, the IOP decreased significantly (p
- Published
- 2017