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Intraocular pressure and visual field changes in normal-tension glaucoma patients treated using either unoprostone or latanoprost: a prospective comparative study
- Source :
- Clinical Ophthalmology (Auckland, N.Z.)
- Publication Year :
- 2017
-
Abstract
- Daisuke Takemoto, Tomomi Higashide, Yoshiaki Saito, Shinji Ohkubo, Sachiko Udagawa, Hisashi Takeda, Kazuhisa Sugiyama Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan Purpose: We conducted a prospective study in patients with normal-tension glaucoma (NTG) who received either isopropyl unoprostone or latanoprost. We compared the drugs in terms of their effects on intraocular pressure (IOP) and visual field loss progression over a 3-year period. Study design: Prospective, randomized controlled study. Methods: We enrolled 48 patients with newly diagnosed NTG at Kanazawa University Hospital. Eligible patients were randomly allocated (1:1) to receive either unoprostone or latanoprost ophthalmic solutions. The primary outcomes were IOP changes and visual field deterioration within 36 months. Visual field changes were analyzed: the cumulative survival rates were calculated in terms of mean deviation, pattern standard deviation, and total deviation of the upper or lower hemi-visual field, each visual field sector, and guided progression analysis. In addition, we evaluated the progression of glaucomatous optic disc changes using fundus photography and confocal scanning laser ophthalmoscopy. Results: The mean pretreatment IOP was 15.0±2.4 mmHg in the Unoprostone group and 15.2±1.9 mmHg in the Latanoprost group. The mean IOP during the treatment period was 13.7±2.3 mmHg in the Unoprostone group and 13.0±1.8 mmHg in the Latanoprost group. In both groups, the IOP decreased significantly (p
- Subjects :
- visual field
Intraocular pressure
medicine.medical_specialty
genetic structures
Glaucoma
unoprostone
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Normal tension glaucoma
Ophthalmology
Medicine
030212 general & internal medicine
Latanoprost
Prospective cohort study
Original Research
medicine.diagnostic_test
business.industry
normal-tension glaucoma
Fundus photography
Clinical Ophthalmology
medicine.disease
eye diseases
Visual field
chemistry
Unoprostone
latanoprost
030221 ophthalmology & optometry
sense organs
business
medicine.drug
intraocular pressure
Subjects
Details
- ISSN :
- 11775467
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Clinical ophthalmology (Auckland, N.Z.)
- Accession number :
- edsair.doi.dedup.....b32e9d7f61c5377225c656f74fbb4ce7