1. The Role of 11C-Choline PET Imaging in the Early Detection of Recurrence in Surgically Treated Prostate Cancer Patients With Very Low PSA Level <0.5 ng/mL
- Author
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Stefano Costa, Patrick M. Colletti, Cristina Nanni, Alice Ferretti, Lorenzo Fantini, Eugenio Brunocilla, Domenico Rubello, Paolo Castellucci, Stefano Fanti, Francesco Ceci, Riccardo Schiavina, Marcelo Mamede, Chiara Fuccio, Mamede M, Ceci F, Castellucci P, Schiavina R, Fuccio C, Nanni C, BRUNOCILLA E., Fantini L, Costa S, Ferretti A, Colletti PM, Rubello D, and Fanti S.
- Subjects
Male ,11C-choline ,Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Urology ,Early detection ,Multimodal Imaging ,Choline ,chemistry.chemical_compound ,Prostate cancer ,Antigen ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Carbon Radioisotopes ,Early Detection of Cancer ,Prostatectomy ,medicine.diagnostic_test ,business.industry ,11C-choline PET ,prostate cancer ,Prostatic Neoplasms ,General Medicine ,Pet imaging ,Middle Aged ,Prostate-Specific Antigen ,medicine.disease ,Logistic Models ,chemistry ,Positron emission tomography ,Positron-Emission Tomography ,Multivariate Analysis ,Neoplasm Recurrence, Local ,Tomography, X-Ray Computed ,business - Abstract
PURPOSE: This study aims to evaluate the role of (11)C-choline PET/CT in patients with biochemical relapse after radical prostatectomy (RP) showing prostate-specific antigen (PSA) values lower than 0.5 ng/mL. METHODS: We performed (11)C-choline PET/CT in 71 consecutive patients previously treated with RP showing PSA values lower than 0.5 ng/mL. (11)C-Choline PET/CT was performed following standard procedure. (11)C-Choline PET/CT-positive findings were validated by transrectal ultrasonography + biopsy, repeated (11)C-choline PET/CT, other conventional imaging modality, and histology. RESULTS: (11)C-Choline PET/CT was true positive in 15/71 (21.1%). (11)C-Choline uptake was observed in pelvic lymph nodes (7/71; 9.9%), in the prostatic bed (7/71; 9.9%), and in bone (1/71; 1.4%). Mean PSA, PSA doubling time (PSAdt), and PSA velocity (PSAvel) values ± SD in (11)C-choline PET/CT-positive patients was 0.37 ± 0.1 ng/mL, 3.4 ± 2.1 months, and 0.05 ± 0.1 ng/mL/yr, respectively. (11)C-Choline PET/CT was false negative in 2 patients and false positive in 1 patient. Among all variables, only PSAdt and the ongoing hormonal treatment were statistically significant in the prediction of a positive (11)C-choline PET/CT at multivariate analysis. CONCLUSIONS: (11)C-Choline PET/CT could be used early after biochemical failure even if PSA values are very low, preferentially in hormonal resistant patients showing fast PSA kinetics. An early detection of the site of relapse could lead to a personalized and tailored treatment.
- Published
- 2013
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