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The Role of 11C-Choline PET Imaging in the Early Detection of Recurrence in Surgically Treated Prostate Cancer Patients With Very Low PSA Level <0.5 ng/mL
- Source :
- Clinical Nuclear Medicine. 38:e342-e345
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- PURPOSE: This study aims to evaluate the role of (11)C-choline PET/CT in patients with biochemical relapse after radical prostatectomy (RP) showing prostate-specific antigen (PSA) values lower than 0.5 ng/mL. METHODS: We performed (11)C-choline PET/CT in 71 consecutive patients previously treated with RP showing PSA values lower than 0.5 ng/mL. (11)C-Choline PET/CT was performed following standard procedure. (11)C-Choline PET/CT-positive findings were validated by transrectal ultrasonography + biopsy, repeated (11)C-choline PET/CT, other conventional imaging modality, and histology. RESULTS: (11)C-Choline PET/CT was true positive in 15/71 (21.1%). (11)C-Choline uptake was observed in pelvic lymph nodes (7/71; 9.9%), in the prostatic bed (7/71; 9.9%), and in bone (1/71; 1.4%). Mean PSA, PSA doubling time (PSAdt), and PSA velocity (PSAvel) values ± SD in (11)C-choline PET/CT-positive patients was 0.37 ± 0.1 ng/mL, 3.4 ± 2.1 months, and 0.05 ± 0.1 ng/mL/yr, respectively. (11)C-Choline PET/CT was false negative in 2 patients and false positive in 1 patient. Among all variables, only PSAdt and the ongoing hormonal treatment were statistically significant in the prediction of a positive (11)C-choline PET/CT at multivariate analysis. CONCLUSIONS: (11)C-Choline PET/CT could be used early after biochemical failure even if PSA values are very low, preferentially in hormonal resistant patients showing fast PSA kinetics. An early detection of the site of relapse could lead to a personalized and tailored treatment.
- Subjects :
- Male
11C-choline
Oncology
medicine.medical_specialty
medicine.medical_treatment
Urology
Early detection
Multimodal Imaging
Choline
chemistry.chemical_compound
Prostate cancer
Antigen
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Carbon Radioisotopes
Early Detection of Cancer
Prostatectomy
medicine.diagnostic_test
business.industry
11C-choline PET
prostate cancer
Prostatic Neoplasms
General Medicine
Pet imaging
Middle Aged
Prostate-Specific Antigen
medicine.disease
Logistic Models
chemistry
Positron emission tomography
Positron-Emission Tomography
Multivariate Analysis
Neoplasm Recurrence, Local
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 03639762
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Clinical Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....47b905529480157f8e157a4aa31a8752