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Objective To assess whether a lifestyle intervention starting in early pregnancy can reduce the incidence of gestational diabetes mellitus (GDM) among Chinese women with high risk factors. Methods Between January 2020 and September 2021, women at gestational age of 6-15 weeks with high risk factors [body mass index (BMI) of 24-35 kg/m2 or a family history of diabetes] in 4 urban districts and 3 suburban districts of Tianjin were recruited as an intervention cohort. During the same period, the high-risk pregnant women who received routine maternal management from two of the above districts, one in urban and the other in suburban district, were retrospectively enrolled as a control cohort through the hospital system information. Women in the intervention cohort received a combination of online and offline lifestyle intervention (nutrition, exercise, and weight control). At the baseline survey, information including age, family history of diabetes, gestational age, and fasting plasma glucose (FPG) level were collected at the baseline survey. The height and body weight were recorded, and BMI was calculated. All pregnant women underwent two-step GDM screening at gestational age of 24-28 weeks. The comparison between the two cohorts was performed using the t test or the χ2 test. Logistic regression model was used to evaluate the effect of lifestyle intervention on GDM incidence. Results Finally, 106 and 2 348 patients were included in the intervention and control cohorts, respectively. There were statistically significant differences between the two cohorts in gestational age, family history of diabetes proportion, gestational age and FPG level at the baseline survey (P<0.05). At gestational age of 24-28 weeks, the incidence of GDM in the intervention and control cohorts was 19.8% (21/106) and 29.6% (696/2 348), respectively (P=0.029), with a relative risk reduction of 33%. Multivariate logistic regression analysis showed that the risk of GDM was significantly lower in the intervention cohort than that in the control cohort, with an OR and 95% confidence interval of 0.41 (0.24-0.69). Conclusion Lifestyle intervention (nutrition, exercise, and weight control) starting in early pregnancy can reduce the incidence of GDM in pregnant women with high risk factors. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the effect of different diabetic risk score in screening for diabetes mellitus in the health check-up population, and to analyze the risk factors of abnormal glucose metabolism. Methods Diabetes risk scores screening was conducted in people who participated physical examination in Medical Examination Center of Beijing Hospital in 2015. The area under the curve (AUC) of the receiver operating characteristic curve was used to reflect the accuracy of the screening method. The relevant risk factors of abnormal glucose metabolism were used by multivariate logistic regression analysis. Results (1) The AUC of screening for diabetes by Chinese diabetes risk score (C-DRs) was 0.83 [95% confidence interval (CI) 0.811-0.843], and the best cut-point value was 26.5. The sensitivity was 83.48%, the specificity was 61.45%, and the Younden index was 0.45 (P<0.05). (2) Age [odds ratio (OR)=2.646, 95%CI: 1.707-4.101], family history of diabetes (OR=13.103, 95%CI: 6.076-28.259), BMI≥25 kg/m2 (OR=2.400, 95%CI: 1.609-2.580), male abdominal circumference≥90 cm (OR=3.869, 95% CI: 1.687-8.872), female abdominal circumference≥85 cm (OR=1.787, 95%CI: 1.183-2.699), hypertention (OR=7.812, 95%CI: 1.560-39.113), high triglyceride (TG) (≥1.7 mmol/L) (OR=1.751, 95%CI: 1.138-2.696), smoking history (OR=3.974, 95% CI: 2.085-7.474), less than 150 min moderate physical activity per week (OR=10.446, 95% CI: 5.304-20.574), more than 100 g carbohydrates per meal (OR=58.581, 95%CI: 24.899-137.826) were risk factors for abnormal glucose metabolism (all P<0.05). (3) In combination with the above risk factors used to screen for diabetes, the AUC was 0.88 (95%CI: 0.862-0.890), the best cut-point value was 31.5, the sensitivity was 88.60%, the specificity 68.68%, the Jordanian index was 0.57 (P<0.05). Conclusions C-DRs is more suitable for diabetes screening in Chinese population. Combined with the factors as: less than 150 min moderate physical activity per week, more than 100 g carbohydrates per meal, smoking history, and high triglycerides, can improve the sensitivity and specificity of screening for diabetes mellitus. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)