1. Organophosphonate Functionalized Gd@C82as a Magnetic Resonance Imaging Contrast Agent.
- Author
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Chun-Ying Shu, Jian-Fei Zhang, Harry W. Gibson, Harry C. Dorn, Frank D. Corwin, Panos P. Fatouros, Chun-Ru Wang, and T. John S. Dennis
- Subjects
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PHOSPHONATES , *MAGNETIC resonance imaging , *ASYMMETRIC synthesis , *MOLECULES - Abstract
A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM −1s −1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM −1s −1) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C 82(16.0 mM −1s −1) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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