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Organophosphonate Functionalized Gd@C82as a Magnetic Resonance Imaging Contrast Agent.
- Source :
-
Chemistry of Materials . Mar2008, Vol. 20 Issue 6, p2106-2109. 4p. - Publication Year :
- 2008
-
Abstract
- A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM −1s −1) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM −1s −1) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C 82(16.0 mM −1s −1) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOSPHONATES
*MAGNETIC resonance imaging
*ASYMMETRIC synthesis
*MOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 08974756
- Volume :
- 20
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Chemistry of Materials
- Publication Type :
- Academic Journal
- Accession number :
- 32793267
- Full Text :
- https://doi.org/10.1021/cm7023982