1. Biologically active ibogan and vallesamine derivatives from Tabernaemontana divaricata.
- Author
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Kam TS, Pang HS, Choo YM, and Komiyama K
- Subjects
- Cell Line, Tumor, Humans, Ibogaine isolation & purification, Indole Alkaloids chemistry, Indole Alkaloids isolation & purification, Indole Alkaloids toxicity, Plant Bark, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Extracts toxicity, Plant Stems, Ibogaine chemistry, Ibogaine toxicity, Tabernaemontana
- Abstract
Six new indole alkaloids, viz., (3S)-3-cyanocoronaridine (2), (3S)-3-cyanoisovoacangine (3), conolobine A (5), conolobine B (6), conolidine (7), and (3R/3S)-3-ethoxyvoacangine (8), in addition to 36 known ones, were obtained from the stem-bark extract of the Malayan Tabernaemontana divaricata. The structures were determined by NMR and MS analysis. The CN-substituted alkaloids showed appreciable cytotoxicity towards the KB human oral epidermoid carcinoma cell-line.
- Published
- 2004
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