Back to Search
Start Over
Biologically active ibogan and vallesamine derivatives from Tabernaemontana divaricata.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2004 Apr; Vol. 1 (4), pp. 646-56. - Publication Year :
- 2004
-
Abstract
- Six new indole alkaloids, viz., (3S)-3-cyanocoronaridine (2), (3S)-3-cyanoisovoacangine (3), conolobine A (5), conolobine B (6), conolidine (7), and (3R/3S)-3-ethoxyvoacangine (8), in addition to 36 known ones, were obtained from the stem-bark extract of the Malayan Tabernaemontana divaricata. The structures were determined by NMR and MS analysis. The CN-substituted alkaloids showed appreciable cytotoxicity towards the KB human oral epidermoid carcinoma cell-line.
- Subjects :
- Cell Line, Tumor
Humans
Ibogaine isolation & purification
Indole Alkaloids chemistry
Indole Alkaloids isolation & purification
Indole Alkaloids toxicity
Plant Bark
Plant Extracts chemistry
Plant Extracts isolation & purification
Plant Extracts toxicity
Plant Stems
Ibogaine chemistry
Ibogaine toxicity
Tabernaemontana
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 1
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 17191876
- Full Text :
- https://doi.org/10.1002/cbdv.200490056