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The intramolecular 1,5-H transfer reaction of the aryl radicals generated from unactivated aryl iodides by photocatalysis is described. The features of this transformation are operational simplicity, excellent yields, mild reaction conditions, and good functional group tolerance. With this approach, a more concise formal synthesis of (±)-coerulescine and (±)-physovenine is accomplished.

A variety of 2-fluoroallylic amines, ethers, esters, and alkylation products are efficiently obtained with high Z-selectivity through regioselective activation of gem-difluorinated cyclopropanes induced by C—C bond cleavage.

A multistereogenic salen–Mn(III) complex bearing an aromatic pocket and two benzylic groups as helping hands was found to be efficient in the catalysis of asymmetric cyanosilylation. The salen–Mn catalyst partially mimics the functions of biocatalysts by reasonably utilizing the steric and electronic properties of the catalytic center to interact with the substrate.

A range of 2H-naphthalene and -chromene derivatives are synthesized via efficient Cu-catalyzed intramolecular hydroarylation reactions of appropriate alkynes.

AuI/CuI-co-catalyzed tandem 1,3-acyloxy migration/trifluoromethylation reaction of propargyl esters to give α-trifluoromethyl enones in moderate yields and with excellent stereoselectivity is described. It is proposed that the reaction proceeds through the 1,3-acyloxy migration of the propargyl esters catalyzed by AuI to produce an allenic intermediate, followed by its trifluoromethylation to give the final product.

The unprecedented and new title reaction represents the first example of endo-type carbotrifluoromethylation of unsaturated C—C bonds.

The asymmetric Henry reaction of aromatic aldehydes and nitromethane catalyzed by an aryl-BINMOL-derived salen-Co(III) complex (BSC) proceeds with high yields and excellent enantioselectivities.

The title reaction proceeds in the presence of quinidine-derived catalyst to form 3-aminooxindole derivatives with moderate diastereoselectivities and high enantioselectivities.

A copper-mediated trifluoromethylation of propargyl acetates with S-(trifluoromethyl)diphenylsulfonium triflate leading to trifluoromethylated allenes in moderate to excellent yields is described.

Triethoxysilane plays a key role in the palladium-catalyzed isomerization of terminal alkenes (I).

Allylic alkylation of 1,3-diaryl-2-propenyl acetates leads to 1,3-diarylpent-1-enes without any enantiomeric excess.

The title compound shows potent antifungal activity against cryptococcus neoformans, trichophyton rubrum, and microsporum gypseum with an MIC value of 0.41 μM.

The first binodal 5,9-connected lead borate Pb6B4O11(OH)2 is obtained by hydrothermal conversion of Pb(BO2)2·H2O (autoclave, 170 °C, 6 d, 33% yield).

Furanones of type (III) are useful synthons which can be converted into optically active butyrolactones such as (IV) and amino diols like (V).

The annulation proceeds with anti- or syn-stereoselectivity depending on the N-protecting group of starting oxindoles.

The title reaction affords succinimide derivatives having adjacent tertiary and quaternary stereocenters.

The first metal-free asymmetric 1,3-dipolar cycloaddition of N-arylmaleimides to azomethine ylides catalyzed by chiral tertiary amine thiourea to form multiply substituted pyrrolidines in excellent yields (up to 89 %) and enantioselectivities (up to 96 % ee) is presented. This procedure allows a rapid diversity-oriented synthesis of chiral pyrrolidine derivatives with high optical purity.

Under optimized conditions, acetone as well as cyclic ketones give the corresponding chiral tertiary α-hydroxycarboxylic esters with up to 96% e.e.

Two ethyl thioglycosides of D-fructofuranose 4a and 4b, synthesized from D-arabinose and differentially protected at position 1 and 6, react with bulky acceptors in the presence of IDCP giving only α-frucofuranosides in essentially quantitative yields.

All enantiomeric stereoisomers of 1,2,3-trihydroxy-4E-octadecene, key intermediates for the syntheses of sphingosines were prepared using sugar as chiral pool

D-ribo-Phytosphingosine has been synthesized from D-galactose via the key intermediate 5, itself prepared by stereoselective prop-2-ynylation with prop-2-ynyl bromide and zinc, and L-lyxo-phytosphingosine has been synthesized from D-xylose via the key intermediate 18, itself prepared by a CBr4–Ph3P–Zn Wittig reaction and debromination. These key chiral intermediates, 5 and 18, have potential as intermediates for the synthesis of other phytosphigosine derivatives.

A series of 16 thiadiazole-based thioglycosides of type (IV) or (VI) are prepared and tested in vivo as sodium-glucose co-transporter 2 (SGLT2) inhibitors.

The syntheses of several biologically interesting acyclic natural products such as LTA, 1, LTB4 8, mosquito oviposition attractant pheromone 46 and cytotoxic annonaceous acetogenin corossolone 57 and corossoline 58 from sugars in our laboratory are reviewed.

A new facile route to (2E,4E)-dienals by a double formyl-olefination with arsonium salts has been developed. By this method and with other arsonium reagents in the key step some lipoxygenase metabolites of arachidonic acid, lipoxin A4 and B4 and leukotriene B4, have been synthesized.

A novel two-dimensional solid, [{Cu(en)2}4(H4W12O42)]·9H2O (en = ethylenediamine), has been prepared under mild hydrothermal conditions. Single crystal X-ray diffraction revealed that each paradodecatungstate [H4W12O42]8− cluster in the title compound is connected with its four adjacent clusters through eight {Cu(en)2}2+ bridging groups into a two-dimensional layered structure. Its cyclic voltammetric behavior in aqueous electrolyte demonstrated that its modified carbon paste electrode has a good stability. A probe reaction indicated that the catalytic activity of paradodecatungstates in epoxidation of maleic anhydride has been enhanced by assembling paradodecatungstate clusters into extended structures.

Six organically directed 1-D iron sulfates hydrated and hydrolyzed to different extents have been prepared hydrothermally. [C2H10N2]1.5[Fe(SO4)(3)].2H2O (I), [C2H10N2][Fe(SO4)2(OH)].H2O (II), [C6H18N2]0.5[Fe(SO4)2(H2O)2] (III), and [C6H18N2]0.5[Fe2(SO4)(H2O)4(OH)].H2O (V) possess the linear topological structures observed in ferrinatrite, sideronatrite, kröhnkite, and copiapite minerals, respectively. [C4H12N2][Fe2(SO4)3(OH)2(H2O)2].H2O (IV) shows a novel linear structure that can be regarded as a hybrid of the tancoite and butlerite types. [C6N4H22]0.5[Fe(SO4)2(OH)].2H2O (VI) adopts a cis configuration, compared with II, to give a rare inorganic helical iron sulfate chain which is a new member of the organically directed transitional metal sulfates. The results reveal that the starting molar proportion of the reactants and the type of amines are critical for the structural motif. There is an obvious relationship between the constitution of chains and the type of amino groups, involving the amount of N-H...O hydrogen bonds.