1. New Routes to 1,2-Dithiole-3-thiones and 3-Imines
- Author
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Konstantin A. Lyssenko, Vladimir A. Ogurtsov, Charles W. Rees, Oleg A. Rakitin, and Alexey A. Smolentsev
- Subjects
Cancer chemotherapy ,Simple (abstract algebra) ,Chemistry ,medicine ,Organic chemistry ,General Chemistry ,General Medicine ,Chloride ,Value (mathematics) ,Combinatorial chemistry ,medicine.drug - Abstract
The reaction of readily available 3,4,5-trichloro-1,2-dithiolium chloride 1 and 4,5-dichloro-1,2-dithiole-3-thione 2 with o-substituted anilines provides a simple route to 1,2-dithiole-3-thiones and 3-imines, which can be cyclised to give new, more complex heterocyclic systems such as 1,2-dithiolo[4,3-b][1,4]benzoxazine of potential value in cancer chemotherapy
- Published
- 2005
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