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2 results on '"Ruifang Nie"'

1. Water-mediated C–H activation of arenes with secure carbene precursors: the reaction and its application

Author

Yong Wu, Songyang Lv, Li Guo, Yingying Xu, Ruizhi Lai, Qiantao Wang, and Ruifang Nie

Subjects
010405 organic chemistry, Chemistry, Metals and Alloys, General Chemistry, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Materials Chemistry, Ceramics and Composites, Carbene
Abstract

A water-mediated C-H activation using sulfoxonium ylides is reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Notably, the "water-mediated" activation, in contrast to that in organic solvents, shows great potential in pharmaceutical, biochemistry and chemical industries.

Published
2019

2. C–H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group

Author

Li Guo, Lingmei Guo, Ruifang Nie, Hui-jing Wang, Yong Wu, Shan Lv, Baolan Tang, Yanzhao Liu, and Li Hai

Subjects
Sulfonyl, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Metals and Alloys, Oxide, General Chemistry, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Group (periodic table), Functional group, Materials Chemistry, Ceramics and Composites
Abstract

The first example of transition-metal-catalyzed C-H activations of 2-phenylisatogens with alkynes and sulfonyl azides has been developed using N-oxide as the directing group. Ru(ii)-Catalyzed C-H alkenylation/cyclization and Ir(iii)-catalyzed direct C-H sulfamidation proceeded with good yields and excellent functional group tolerance. Importantly, these two transformations provided straightforward routes for the synthesis of indol-3-one derivatives and sulfamidated 2-phenylisatogens respectively, which might be of considerable bioactivities.

Published
2019

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